CAS Number547-32-0
Synonymssulfadiazine sodium; MFCD00067333; Sodium [(4-aminophenyl)sulfonyl](2-pyrimidinyl)azanide; Sodium sulfadiazine; Sulphadiazine sodium; Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, sodium salt (1:1); sodium,(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide; EINECS 208-919-0; sodium [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide
Molecular FormulaC10H9N4NaO2S
Molecular Weight272.26
Purity≥98 (HPLC)%
Density1.496g/cm3
Boiling Point512.6ºC at 760 mmHg
Appearancecrystalline powder
EINECS208-919-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 547-32-0 |
| Catalog No. | 2A-9022805 |
| Chinese Name | 磺胺嘧啶钠 |
| Synonyms | sulfadiazine sodium; MFCD00067333; Sodium [(4-aminophenyl)sulfonyl](2-pyrimidinyl)azanide; Sodium sulfadiazine; Sulphadiazine sodium; Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, sodium salt (1:1); sodium,(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide; EINECS 208-919-0; sodium [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide |
| Molecular Formula | C10H9N4NaO2S |
| Molecular Weight | 272.26 |
| Purity | ≥98 (HPLC) |
| Density | 1.496g/cm3 |
| Boiling Point | 512.6ºC at 760 mmHg |
| Appearance | crystalline powder |
| Storage Condition | 2-8°C |
| Packaging | III |
| Application | Sulfadiazine sodium belongs to the sulfonamide antibiotics and is used for veterinary purposes, mainly in the pig industry. Sulfadiazine sodium is also effective against toxoplasmosis. |
| EINECS | 208-919-0 |
| HTC | 2935009090 |
| PubChem ID | 329824562 |
| MDL Number | MFCD00067333 |
| SMILES | Nc1ccc(cc1)S(=O)(=O)N([Na])c2ncccn2 |
| InChI | 1S/C10H9N4O2S.Na/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1 |
| InChI Key | JLDCNMJPBBKAHH-UHFFFAOYSA-N |
| Beilstein/REAXYS | 4068213 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/22805_1_547_32_0.pdf |
| Bioactivity | Sulfadiazine sodium belongs to the class of sulfonamide antibiotics that are used for veterinary purposes worldwide, mainly in pig production. Sulfadiazine sodium is also used for toxoplasmosis[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial In Vivo In this study, the effectiveness of Sulfadiazine sodium and Pyrimetamine for the treatment of mice during acute infection with different atypical T. gondii strains was evaluated. Swiss mice were infected with seven T. gondii strainsl. The infected mice were treated with 10-640 mg/kg per day of Sulfadiazine sodium, 3-200 mg/kg per day of Pyrimetamine, or a combination of both drugs with a lower dosage. A descriptive analysis was used to assess the association between susceptibility to sodium and/or Pyrimetamine and the genotype. The TgCTBr4 and TgCTBr17 strains (genotype 108) presented lower susceptibility to sodium or Pyrimetamine treatment. The TgCTBr1 and TgCTBr25 strains (genotype 206) presented similar susceptibility to PYR but not sodium treatment. The TgCTBr9 strain (genotype 11) was the only strain with high susceptibility to treatment with both drugs [1]. References [1]. Kopmann C, et al. Abundance and transferability of antibiotic resistance as related to the fate of sulfadiazine in maize rhizosphere and bulk soil. FEMS Microbiol Ecol. 2013 Jan;83(1):125-34. [2]. Silva LA, et al. Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil. Exp Parasitol. 2019 Jul;202:7-14. Chemical & Physical Properties Density 1.496g/cm3 Boiling Point 512.6ºC at 760 mmHg Molecular Formula C10H9N4NaO2S Molecular Weight 272.259 Flash Point 263.8ºC Exact Mass 272.034393 PSA 97.56000 LogP 2.38040 InChIKey JLDCNMJPBBKAHH-UHFFFAOYSA-N SMILES Nc1ccc(S(=O)(=O)[N-]c2ncccn2)cc1.[Na+] Storage condition 2-8°C |
| Use of | Sulfadiazine sodium belongs to the class of sulfonamide antibiotics that are used for veterinary purposes worldwide, mainly in pig production. Sulfadiazine sodium is also used for toxoplasmosis[1][2]. Properties Name Sulfadiazine sodium salt Synonym More Synonyms Sulfadiazine sodium Biological Activity Description Sulfadiazine sodium belongs to the class of sulfonamide antibiotics that are used for veterinary purposes worldwide, mainly in pig production. Sulfadiazine sodium is also used for toxoplasmosis[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial References [1]. Kopmann C, et al. Abundance and transferability of antibiotic resistance as related to the fate of sulfadiazine in maize rhizosphere and bulk soil. FEMS Microbiol Ecol. 2013 Jan;83(1):125-34. [2]. Silva LA, et al. Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil. Exp Parasitol. 2019 Jul;202:7-14. Chemical & Physical Properties Molecular Formula C10H9N4NaO2S Exact Mass 272.034393 PSA 97.56000 LogP 2.38040 InChIKey JLDCNMJPBBKAHH-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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