CAS Number130-85-8
SynonymsPamoic; 1,1'-Methylene-bis(2-hydroxy-3-naphthoic acid); 4,4-Methylenebis(3-Hydroxy-2-Naphthoic Acid); EMBIONIC ACID; PAMOIC ACID FREE ACID; 2,2'-Dihydroxy-1,1'-dinaphthylmethane-3,3'-dicarboxylic Acid; 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid); Pamoic acid; PAMOIC ACID pure; Embonic acid; 4,4'-Methylenedi(3-hydroxy-2-naphthoic Acid); EINECS 204-998-0; MFCD00004079
Molecular FormulaC23H16O6
Molecular Weight388.37
Purity≥97.0 (T)%
Density1.5±0.1 g/cm3
Boiling Point642.7±55.0 °C at 760 mmHg
Melting Point≥300 °C (dec.)
Appearancefine yellow powder
EINECS204-998-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 130-85-8 |
| Catalog No. | 2A-0202222 |
| Chinese Name | 帕莫酸 |
| Synonyms | Pamoic; 1,1'-Methylene-bis(2-hydroxy-3-naphthoic acid); 4,4-Methylenebis(3-Hydroxy-2-Naphthoic Acid); EMBIONIC ACID; PAMOIC ACID FREE ACID; 2,2'-Dihydroxy-1,1'-dinaphthylmethane-3,3'-dicarboxylic Acid; 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid); Pamoic acid; PAMOIC ACID pure; Embonic acid; 4,4'-Methylenedi(3-hydroxy-2-naphthoic Acid); EINECS 204-998-0; MFCD00004079 |
| Molecular Formula | C23H16O6 |
| Molecular Weight | 388.37 |
| Purity | ≥97.0 (T) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 642.7±55.0 °C at 760 mmHg |
| Melting Point | ≥300 °C (dec.) |
| Appearance | fine yellow powder |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Storage Condition | Room Temperature |
| Application | Pamoic acid is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid has neuroprotective and anti-inflammatory properties [1][2]. |
| EINECS | 204-998-0 |
| HTC | 2917399090 |
| PubChem ID | 57650260 |
| MDL Number | MFCD00004079 |
| SMILES | OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(O)=O)c1O |
| InChI | 1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29) |
| InChI Key | WLJNZVDCPSBLRP-UHFFFAOYSA-N |
| Beilstein/REAXYS | 901319 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| MSDS | msds/20656_1_130_85_8.pdf |
| Bioactivity | Pamoic acid is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK Target EC50: 79 nM (GPR35)[1] In Vitro GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes[1]. In Vivo In a mouse model of stroke, that GPR35 activation by Pamoic acid (s.c.; 50-100 mg/kg) is neuroprotective. Pharmacological inhibition of GPR35 reveals that Pamoic acid reduces infarcts size in a GPR35 dependent manner. Pamoic acid treatment results in a preferential increment of noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain along with the reduced neutrophil counts[1]. References [1]. Ozayra Sharmin, et al. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sci Rep. 2020 Jun 10;10(1):9400. [2]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 642.7±55.0 °C at 760 mmHg Melting Point ≥300 °C (dec.) Molecular Formula C23H16O6 Molecular Weight 388.38 Flash Point 356.5±28.0 °C Exact Mass 388.094696 PSA 115.06000 LogP 6.35 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.782 InChIKey WLJNZVDCPSBLRP-UHFFFAOYSA-N SMILES O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O Water Solubility PRACTICALLY INSOLUBLE |
| Use of | Pamoic acid is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2]. Properties Articles22 Name pamoic acid Synonym More Synonyms Pamoic acid Biological Activity Description Pamoic acid is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK EC50: 79 nM (GPR35)[1] References [1]. Ozayra Sharmin, et al. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sci Rep. 2020 Jun 10;10(1):9400. [2]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8. Chemical & Physical Properties Molecular Formula C23H16O6 Exact Mass 388.094696 PSA 115.06000 Index of Refraction 1.782 InChIKey WLJNZVDCPSBLRP-UHFFFAOYSA-N Water Solubility PRACTICALLY INSOLUBLE |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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