![4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID structure, CAS 331830-20-7](/structures/180000/170624_2_331830_20_7.png)
CAS Number331830-20-7
Synonyms1,4-Dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid; 4-Hydroxy-1,10-phenanthroline-3-carboxylic acid; 4-Oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid; 4-Oxo-1,4-dihydro-[1,10]phenanthroline-3-carboxylic acid; 1,4-dpca; MFCD07357380
Molecular FormulaC13H8N2O3
Molecular Weight240.214
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point474.5±45.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 331830-20-7 |
| Catalog No. | 2A-1170458 |
| Chinese Name | 4-氧代-1,4-二氢-1,10-菲咯啉-3-羧酸 |
| Synonyms | 1,4-Dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid; 4-Hydroxy-1,10-phenanthroline-3-carboxylic acid; 4-Oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid; 4-Oxo-1,4-dihydro-[1,10]phenanthroline-3-carboxylic acid; 1,4-dpca; MFCD07357380 |
| Molecular Formula | C13H8N2O3 |
| Molecular Weight | 240.214 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 474.5±45.0 °C at 760 mmHg |
| Application | 1,4-DPCA, a potent and selective prolyl-4-hydroxylase inhibitor, is also an inhibitor of collagen hydroxylation in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits the prolyl-4-hyd |
| HTC | 2933990090 |
| PubChem ID | 610217 |
| InChI | InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18) |
| InChI Key | XZZHOJONZJQARN-UHFFFAOYSA-N |
| Use of | 1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 μM[1][2]. Properties Name 4-oxo-1,4-dihydro-[1,10]phenanthroline-3-carboxylic acid Synonym More Synonyms 1,4-DPCA Biological Activity Description 1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 μM[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase IC50: 2.4 µM (Collagen hydroxylation); 60 μM (Factor inhibiting HIF (FIH))[2] In Vivo 1,4-DPCA treatment suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) (PLGA) discs implanted in the peritoneal cavity for 28 days in mice. 1,4-DPCA is found to be effective at inhibiting collagen deposition within and on the outer surface of the disc, and also limited connective tissue ingrowth, but not to the extent of glucocorticoid inhibition[2]. References [1]. Yong Zhang, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92. [2]. Ryan J Love, et al. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606. [3]. Gaofeng Xiong, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1. Chemical & Physical Properties Molecular Formula C13H8N2O3 Exact Mass 240.053497 PSA 83.05000 Index of Refraction 1.727 Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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