![[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate structure, CAS 150080-09-4](/structures/180000/170542_2_150080_09_4.png)
CAS Number150080-09-4
SynonymsBoronic acid, B-[(2R)-1-[(2S)-2-amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-, methanesulfonate (1:1); Talabostat mesylate (USAN); Methanesulfonic acid ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid (1:1); [(2R)-1-(L-Valyl)-2-pyrrolidinyl]boronic acid methanesulfonate (1:1); Talabostat mesylate; Talabostat (mesylate)
Molecular FormulaC10H23BN2O6S
Molecular Weight310.175
Purity98.00%
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 150080-09-4 |
| Catalog No. | 2A-1170388 |
| Chinese Name | Talabostat 甲磺酸盐 |
| Synonyms | Boronic acid, B-[(2R)-1-[(2S)-2-amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-, methanesulfonate (1:1); Talabostat mesylate (USAN); Methanesulfonic acid ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid (1:1); [(2R)-1-(L-Valyl)-2-pyrrolidinyl]boronic acid methanesulfonate (1:1); Talabostat mesylate; Talabostat (mesylate) |
| Molecular Formula | C10H23BN2O6S |
| Molecular Weight | 310.175 |
| Purity | 98.00 |
| Storage Condition | 2-8℃ |
| Application | Talabostat mesylate is a highly potent, non-selective, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. |
| HTC | 2933990090 |
| PubChem ID | 16624405 |
| SMILES | CC(C)C(N)C(=O)N1CCCC1B(O)O.CS(=O)(=O)O |
| InChI | InChI=1S/C9H19BN2O3.CH4O3S/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15;1-5(2,3)4/h6-8,14-15H,3-5,11H2,1-2H3;1H3,(H,2,3,4)/t7-,8-;/m0./s1 |
| InChI Key | OXYYOEIGQRXGPI-WSZWBAFRSA-N |
| Use of | Talabostat mesylate is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Properties Name [(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid,methanesulfonic acid Synonym More Synonyms Talabostat mesylate Biological Activity Description Talabostat mesylate is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Cancer Research Areas >> Inflammation/Immunology Ki: 0.18 nM (DPP-IV), 1.5 nM (DPP8), 0.76 nM (DPP9)[1] References [1]. Connolly BA, et al. Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potencyand in vivo efficacy and safety. J Med Chem. 2008 Oct 9;51(19):6005-13. [2]. Okondo MC, et al. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat Chem Biol. 2017 Jan;13(1):46-53. [3]. Adams S, et al. PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Res. 2004 Aug 1;64(15):5471-80. [4]. Egger C, et al. Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis. Eur J Pharmacol. 2017 Aug 15;809:64-72. Chemical & Physical Properties Molecular Formula C10H23BN2O6S Exact Mass 310.136993 PSA 149.54000 LogP 0.61560 InChIKey OXYYOEIGQRXGPI-WSZWBAFRSA-N Storage condition 2-8℃ Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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