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Acrichin dihydrochloride structure, CAS 69-44-3

Acrichin dihydrochloride

CAS Number69-44-3

SynonymsPhenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, hydrochloride (1:1); TCMDC-123932; camoquinhydrochloride; EINECS 200-706-0; 4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol hydrochloride (1:1); Camoquin Hcl; AMODIAQUIN DIHYDROCHLORIDE; AMODIAQUINE HCL; AMODIAQUIN HYDROCHLORIDE; AMODIAQUINE DIHYDROCHLORIDE; 4-[(7-Chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol hydrochloride (1:1); AMODIAQUINE HYDROCHLORIDE

Molecular FormulaC20H24O1N3Cl3

Molecular Weight428.79

Purity98.00%

Density

Boiling Point478ºC at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9016981 Purity: 98.00%
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Quality Control of [ 69-44-3 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number69-44-3
Catalog No.2A-9016981
Chinese Name盐酸阿莫地喹
SynonymsPhenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, hydrochloride (1:1); TCMDC-123932; camoquinhydrochloride; EINECS 200-706-0; 4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol hydrochloride (1:1); Camoquin Hcl; AMODIAQUIN DIHYDROCHLORIDE; AMODIAQUINE HCL; AMODIAQUIN HYDROCHLORIDE; AMODIAQUINE DIHYDROCHLORIDE; 4-[(7-Chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol hydrochloride (1:1); AMODIAQUINE HYDROCHLORIDE
Molecular FormulaC20H24O1N3Cl3
Molecular Weight428.79
Purity98.00
Boiling Point478ºC at 760 mmHg
Appearancepowder
Storage Condition-20℃
ApplicationAmodiaquine dihydrochloride (Amodiaquin dihydrochloride) is a 4-aminoquinoline antimalarial agent and a potent orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride is als
HTC2933499090
MDL NumberMFCD00078857
SMILESCCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O.Cl
InChIInChI=1S/C20H22ClN3O.2ClH/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);2*1H
InChI KeyKBTNVJNLEFHBSO-UHFFFAOYSA-N
MSDSmsds/16981_1_69_44_3.pdf
Use ofAmodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4]. Properties Name Acrichin dihydrochloride Synonym More Synonyms Amodiaquine dihydrochloride Biological Activity Description Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4]. Related Catalog Research Areas >> Infection Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease EC50: ~20 μM (Nurr1-LBD (ligand binding domain))[1] Histamine N-methyltransferase[3] References [1]. Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. [2]. Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54. [3]. Akira Yokoyama, et al. Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. [4]. M T HOEKENGA. The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine. Am J Trop Med Hyg. 1954 Sep;3(5):833-8. Chemical & Physical Properties Exact Mass 391.121826 PSA 48.39000 LogP 6.05420 InChIKey KBTNVJNLEFHBSO-UHFFFAOYSA-N Storage condition -20℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-, dihydrochloride CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T66 BNJ IG EMR DQ C1N2&2 &GH 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Blood - agranulocytosis REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,717,1986 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,1471,1981 Safety Information Hazard Codes N HS Code 2933499090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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