CAS Number68-04-2
SynonymsFEMA 3026; trisodium citrate; anhydrous sodium citrate; Na3-citrate; citnatin; citrosodna; citrosodina; MFCD00012462; natrocitral; citric acid trisodium salt; citreme; citrosodine; anhydrous trisodium citrate; Citric acid 3Na; EINECS 200-675-3
Molecular FormulaC6H5Na3O7
Molecular Weight258.07
Purity99.00%
Density1.008 g/mL at 20 °C
Melting Point150 °C (decomposition)
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68-04-2 |
| Catalog No. | 2A-9016965 |
| Chinese Name | 柠檬酸钠 |
| Synonyms | FEMA 3026; trisodium citrate; anhydrous sodium citrate; Na3-citrate; citnatin; citrosodna; citrosodina; MFCD00012462; natrocitral; citric acid trisodium salt; citreme; citrosodine; anhydrous trisodium citrate; Citric acid 3Na; EINECS 200-675-3 |
| Molecular Formula | C6H5Na3O7 |
| Molecular Weight | 258.07 |
| Purity | 99.00 |
| Density | 1.008 g/mL at 20 °C |
| Melting Point | 150 °C (decomposition) |
| Appearance | solid |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | Trisodium citrate is a natural preservative and food sourness enhancer. Trisodium citrate induces apoptosis and cell cycle arrest in G2/M phase and S phase. Trisodium citrate causes oxidative damage t |
| HTC | 2918150000 |
| MDL Number | MFCD00012462 |
| SMILES | [Na+].[Na+].[Na+].[O-]C(=O)C(O)(CC(=O)[O-])CC(=O)[O-] |
| InChI | 1S/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 |
| InChI Key | HRXKRNGNAMMEHJ-UHFFFAOYSA-K |
| UNSPSC | 12352107 |
| Hazard Symbols | Transport |
| MSDS | msds/16965_1_68_04_2.pdf |
| Bioactivity | Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice[1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Metabolic Disease In Vitro Citric acid trisodium (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner[3]. Citric acid trisodium (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3]. Citric acid trisodium (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3]. Cell Viability Assay[3] Cell Line: HaCaT cells Concentration: 0, 2.5, 5, 7.5, 10, 12.5 mM Incubation Time: 24 h Result: Inhibited the cell viability in a dose dependent manner. Cell Cycle Analysis[3] Cell Line: HaCaT cells Concentration: 12.5 mM Incubation Time: 0, 12, 24, 48, 72 h Result: Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner. Western Blot Analysis[3] Cell Line: HaCaT cells Concentration: 12.5 mM Incubation Time: 12, 24, 48 h Result: Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl. In Vivo Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver[1]. Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1]. Citric acid trisodium (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice[2]. Animal Model: 20 g male Kunming mice[2] Dosage: 120, 240, 480 mg/kg Administration: I.p.; weekly for 3 weeks Result: T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased. References [1]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. [2]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44. [3]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20. Chemical & Physical Properties Density 1.008 g/mL at 20 °C Melting Point 300°C Molecular Formula C6H5Na3O7 Molecular Weight 258.069 Exact Mass 257.972839 PSA 140.62000 InChIKey HRXKRNGNAMMEHJ-UHFFFAOYSA-K SMILES O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+] Storage condition 2-8°C |
| Use of | Properties Articles1096 Name Sodium citrate Synonym More Synonyms Sodium citrate Biological Activity Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Metabolic Disease References [1]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. [2]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44. [3]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20. Chemical & Physical Properties Molecular Formula C6H5Na3O7 Exact Mass 257.972839 PSA 140.62000 InChIKey HRXKRNGNAMMEHJ-UHFFFAOYSA-K SMILES O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+] |
| Tax Rebate | 13.0% |
| Supervision | 4. Export license A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods x. Export license (processing trade) y. Export license (small-scale border trade) |
| Inspection | R. Imported food hygiene supervision and inspection S. Export food hygiene supervision and inspection N. Export commodity inspection |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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