CAS Number67-42-5
SynonymsEgtazic acid; ethylene glycol bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid; Egtazic; 4F 4PP oxalate; CHEL-DE; Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid; EGTA; AEGT; ethylene glycol bis(2-aminoethyl)tetraacetic acid; (Ethylenebis(oxyethylenenitrilo))tetraacetic acid; Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid; EINECS 200-651-2; Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid; Ethylenebis(oxyethylenenitrilo)tetraacetic acid; MFCD00004291; 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioic acid; chel tm-de; GIETA; [ethylenebis(oxyethylenenitrilo)]tetraacetic acid; GEDTA; ebonta; 3,6-dioxaoctamethylenedinitrilotetraacetic acid
Molecular Formula[-CH2OCH2CH2N(CH2CO2H)2]2
Molecular Weight380.35
Purity≥97.0%
Density1.4±0.1 g/cm3
Boiling Point678.0±55.0 °C at 760 mmHg
Melting Point241 °C (dec.) (lit.)
Appearancepowder
EINECS200-651-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 67-42-5 |
| Catalog No. | 2A-9016947 |
| Chinese Name | 3,6-二氧杂-1,8-辛二胺四乙酸(EGTA) |
| Synonyms | Egtazic acid; ethylene glycol bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid; Egtazic; 4F 4PP oxalate; CHEL-DE; Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid; EGTA; AEGT; ethylene glycol bis(2-aminoethyl)tetraacetic acid; (Ethylenebis(oxyethylenenitrilo))tetraacetic acid; Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid; EINECS 200-651-2; Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid; Ethylenebis(oxyethylenenitrilo)tetraacetic acid; MFCD00004291; 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioic acid; chel tm-de; GIETA; [ethylenebis(oxyethylenenitrilo)]tetraacetic acid; GEDTA; ebonta; 3,6-dioxaoctamethylenedinitrilotetraacetic acid |
| Molecular Formula | [-CH2OCH2CH2N(CH2CO2H)2]2 |
| Molecular Weight | 380.35 |
| Purity | ≥97.0 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 678.0±55.0 °C at 760 mmHg |
| Melting Point | 241 °C (dec.) (lit.) |
| Appearance | powder |
| Water Solubility | slightly soluble |
| Storage Condition | This product should be kept sealed. |
| Application | EGTA is a special calcium ion chelating agent. EGTA has a Kd of 60.5 nM at physiological pH (7.4) and is highly specific for Ca2+ than Mg2+. EGTA significantly inhibits the substrate adhesion ability |
| EINECS | 200-651-2 |
| HTC | 29225000 |
| PubChem ID | 24894530 |
| MDL Number | MFCD00004291 |
| SMILES | OC(=O)CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O |
| InChI | 1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24) |
| InChI Key | DEFVIWRASFVYLL-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1717370 |
| NACRES Code | NA.31 |
| UNSPSC | 12352106 |
| Hazard Symbols | Transport |
| MSDS | msds/16947_1_67_42_5.pdf |
| Bioactivity | EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibited the substrate adherence capacity of inflammatory macrophages[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology In Vitro EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2]. References [1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426 [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 678.0±55.0 °C at 760 mmHg Melting Point 241 °C (dec.)(lit.) Molecular Formula C14H24N2O10 Molecular Weight 380.348 Flash Point 363.9±31.5 °C Exact Mass 380.143097 PSA 174.14000 LogP -2.53 Vapour Pressure 0.0±4.5 mmHg at 25°C Index of Refraction 1.547 InChIKey DEFVIWRASFVYLL-UHFFFAOYSA-N SMILES O=C(O)CN(CCOCCOCCN(CC(=O)O)CC(=O)O)CC(=O)O Storage condition Store at RT. Water Solubility slightly soluble |
| Use of | Properties Articles1081 Name ethylene glycol bis(2-aminoethyl)tetraacetic acid Synonym More Synonyms EGTA Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213. Chemical & Physical Properties Molecular Formula C14H24N2O10 Exact Mass 380.143097 PSA 174.14000 LogP -2.53 Index of Refraction 1.547 InChIKey DEFVIWRASFVYLL-UHFFFAOYSA-N SMILES O=C(O)CN(CCOCCOCCN(CC(=O)O)CC(=O)O)CC(=O)O Storage condition Store at RT. Water Solubility slightly soluble |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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