CAS Number69-81-8
Synonymsadchnon; cartabes; ADRENOXYL; CROMADRENAL; CROMOSIL; adroxon; adedolon; EINECS 200-717-0; adrezon; Adrenochrom-monosemicarbazon; Carbazochrome; (2Z)-2-(3-Hydroxy-1-methyl-6-oxo-1,2,3,6-tetrahydro-5H-indol-5-ylidene)hydrazinecarboxamide; adrokson; MFCD00130253
Molecular FormulaC10H12N4O3
Molecular Weight236.23
Purity98.00%
Density1.6±0.1 g/cm3
Melting Point203° (dec)
Appearancecarmine crystal powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 69-81-8 |
| Catalog No. | 2A-9016991 |
| Chinese Name | 卡巴克络 |
| Synonyms | adchnon; cartabes; ADRENOXYL; CROMADRENAL; CROMOSIL; adroxon; adedolon; EINECS 200-717-0; adrezon; Adrenochrom-monosemicarbazon; Carbazochrome; (2Z)-2-(3-Hydroxy-1-methyl-6-oxo-1,2,3,6-tetrahydro-5H-indol-5-ylidene)hydrazinecarboxamide; adrokson; MFCD00130253 |
| Molecular Formula | C10H12N4O3 |
| Molecular Weight | 236.23 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Melting Point | 203° (dec) |
| Appearance | carmine crystal powder |
| Storage Condition | Seal and store in a dry place below 0℃. |
| Application | Carbazochrome is a capillary stabilizer used in the study of bleeding. Carbazochrome is an anti-bleeding agent. |
| HTC | 2933990090 |
| MDL Number | C10H12N4O3 |
| SMILES | CN1CC(O)c2cc(N=NC(N)=O)c(O)cc21 |
| InChI Key | SSCSSDNTQJGTJT-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/16991_1_69_81_8.pdf |
| Bioactivity | Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others In Vitro Carbazochrome (0.1-10 µM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3 in a concentration-dependent manner[1].Carbazochrome (0.1-1 µM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances[1]. In Vivo Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats[2]. Animal Model: Male Sprague-Dawley rats weighing 180-230 g[2] Dosage: 10 mg/kg Administration: I.v.; injected 30, 60, or 90 min before Ioxaglate injection (4 g I/kg, i.v.). Result: Attenuated the Ioxaglate-increased vascular permeability at the dose of 1, 5 and 10 mg/kg in a dose-dependent manner, achieving statistical significance at 5 and 10 mg/kg. References [1]. Toshiaki Sendo, et al. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80. [2]. Toshiaki Sendo, et al. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Melting Point 203° (dec) Molecular Formula C10H12N4O3 Molecular Weight 236.227 Exact Mass 236.090942 PSA 108.02000 LogP -1.53 Index of Refraction 1.733 InChIKey SSCSSDNTQJGTJT-UHFFFAOYSA-N SMILES CN1CC(O)c2cc(N=NC(N)=O)c(O)cc21 Storage condition −20°C |
| Use of | Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1]. Properties Articles26 Name Carbazochrome Synonym More Synonyms Carbazochrome Biological Activity Description Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others References [1]. Toshiaki Sendo, et al. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80. [2]. Toshiaki Sendo, et al. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8. Chemical & Physical Properties Molecular Formula C10H12N4O3 Exact Mass 236.090942 PSA 108.02000 LogP -1.53 Index of Refraction 1.733 InChIKey SSCSSDNTQJGTJT-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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