CAS Number56-69-9
SynonymsMFCD00005651; DL-5-HTP; 2-Chloro-3-methylamine-5-trifluoromethylpyridine hydrochloride; EINECS 200-284-8
Molecular FormulaC11H12N2O3
Molecular Weight220.22
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point520.6±50.0 °C at 760 mmHg
Melting Point298-300 °C (dec.) (lit.)
Appearancesolid
EINECS200-284-8
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 56-69-9 |
| Catalog No. | 2A-9016711 |
| Chinese Name | 5-羟色胺酸 |
| Synonyms | MFCD00005651; DL-5-HTP; 2-Chloro-3-methylamine-5-trifluoromethylpyridine hydrochloride; EINECS 200-284-8 |
| Molecular Formula | C11H12N2O3 |
| Molecular Weight | 220.22 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 520.6±50.0 °C at 760 mmHg |
| Melting Point | 298-300 °C (dec.) (lit.) |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Packaging | III |
| Application | 5-Hydroxytryptophan is a metabolite of tryptophan, a direct precursor of 5-hydroxytryptophan (5-HT), and a substrate for aromatic amino acid decarboxylase. |
| EINECS | 200-284-8 |
| HTC | 2929909090 |
| PubChem ID | 329768568 |
| MDL Number | MFCD00005651 |
| SMILES | NC(Cc1c[nH]c2ccc(O)cc12)C(O)=O |
| InChI | 1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16) |
| InChI Key | LDCYZAJDBXYCGN-UHFFFAOYSA-N |
| Beilstein/REAXYS | 88199 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/16711_1_56_69_9.pdf |
| Use of | 5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. [1][2][3]. Properties Name DL-5-Hydroxytryptophan Synonym More Synonyms 5-Hydroxytryptophan Biological Activity Description 5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. [1][2][3]. Related Catalog Research Areas >> Metabolic Disease Human Endogenous Metabolite References [1]. Gartside SE, et al. Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol. 1990 Apr 10;179(1-2):103-9. [2]. Gijsman HJ, et al. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol. 2002 Apr;22(2):183-9. [3]. Schruers K, et al. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Res. 2002 Dec 30;113(3):237-43. Chemical & Physical Properties Molecular Formula C11H12N2O3 Exact Mass 220.084793 PSA 99.34000 LogP -0.14 Index of Refraction 1.737 InChIKey LDCYZAJDBXYCGN-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Tryptophan, 5-hydroxy- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C11-H12-N2-O3 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T56 BMJ D1YZVQ GQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) REFERENCE : ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 24(Suppl 3),1,1963 *** REVIEWS *** TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 Safety Information Hazard Codes Xn RIDADR UN 2811 WGK Germany 3.0 RTECS YN7100000 Packaging Group III HS Code 2929909090 Synthetic Route Wurster's blue CAS#:100-22-1 5-Hydroxytrypto... CAS#:126216-42-0 Wurster's blue CAS#:100-22-1 5-Hydroxytryptophan CAS#:56-69-9 Literature: Journal of Physical Chemistry, , vol. 86, p. 3661 - 3667 4-(Dimethylamin... CAS#:619-60-3 5-Hydroxytrypto... CAS#:126216-42-0 4-(N,N-dimethyl... CAS#:54737-34-7 5-Hydroxytryptophan CAS#:56-69-9 Literature: Journal of Physical Chemistry, , vol. 86, p. 3661 - 3667 5-Hydroxytrypto... CAS#:126216-42-0 CAS#:150-76-5 1-[4-(3,4-dimet... CAS#:6119-32-0 5-Hydroxytryptophan CAS#:56-69-9 Literature: Journal of Physical Chemistry, , vol. 86, p. 3661 - 3667 Precursor & DownStream Precursor 4 CAS#:100-22-1 Wurster's blue CAS#:619-60-3 4-(Dimethylamin... CAS#:150-76-5 CAS#:108-46-3 DownStream 5 CAS#:50-67-9 5-Hydroxytryptamine CAS#:150-76-5 CAS#:108-46-3 CAS#:100-22-1 Wurster's blue |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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