CAS Number56-84-8
Synonymsasparagic acid; 1-amino-1,2-carboxyethane; δ-aspartic acid; d-Asp; QVYZ1VQ &&D or R Form; (-)-Aspartic acid; (2R)-2-Aminosuccinic acid; MFCD00002616; (2R)-2-aminobutanedioic acid; hydrogen D-aspartate; L-Asparticacid; (R)-(−)-Aminosuccinic acid; D-(-)-Aspartic acid; Acide (2R)-2-aminosuccinique; L-Aspartic acid; aspartic acid D-form; D-Aspartic acid; H-D-Asp-OH; EINECS 200-291-6; H-Asp-OH
Molecular FormulaHO2CCH2CH(NH2)CO2H
Molecular Weight133.10
Purity≥98 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point264.1±30.0 °C at 760 mmHg
Melting Point>300 °C (dec.) (lit.)
Appearancepowder, crystals or chunks
EINECS200-291-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 56-84-8 |
| Catalog No. | 2A-9016715 |
| Chinese Name | L-天门冬氨酸 |
| Synonyms | asparagic acid; 1-amino-1,2-carboxyethane; δ-aspartic acid; d-Asp; QVYZ1VQ &&D or R Form; (-)-Aspartic acid; (2R)-2-Aminosuccinic acid; MFCD00002616; (2R)-2-aminobutanedioic acid; hydrogen D-aspartate; L-Asparticacid; (R)-(−)-Aminosuccinic acid; D-(-)-Aspartic acid; Acide (2R)-2-aminosuccinique; L-Aspartic acid; aspartic acid D-form; D-Aspartic acid; H-D-Asp-OH; EINECS 200-291-6; H-Asp-OH |
| Molecular Formula | HO2CCH2CH(NH2)CO2H |
| Molecular Weight | 133.10 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 264.1±30.0 °C at 760 mmHg |
| Melting Point | >300 °C (dec.) (lit.) |
| Appearance | powder, crystals or chunks |
| Water Solubility | 5 g/L (25 ºC) |
| Storage Condition | Store sealed and dry. |
| Application | L-Aspartic acid is an amino acid that has been shown to be a prodrug for colon-specific drug delivery. |
| EINECS | 200-291-6 |
| HTC | 29224995 |
| PubChem ID | 24277948 |
| MDL Number | MFCD00002616 |
| SMILES | N[C@@H](CC(O)=O)C(O)=O |
| InChI | 1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1 |
| InChI Key | CKLJMWTZIZZHCS-REOHCLBHSA-N |
| Beilstein/REAXYS | 1723530 |
| NACRES Code | NA.26 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| Safety Description | S22;S24/25 |
| MSDS | msds/16715_1_56_84_8.pdf |
| Bioactivity | L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly. Related Catalog Natural Products >> Others Research Areas >> Cardiovascular Disease Target Human Endogenous Metabolite In Vivo L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2]. References [1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406. [2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 264.1±30.0 °C at 760 mmHg Melting Point >300 °C (dec.)(lit.) Molecular Formula C4H7NO4 Molecular Weight 133.103 Flash Point 113.5±24.6 °C Exact Mass 133.037506 PSA 100.62000 LogP -0.67 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.531 InChIKey CKLJMWTZIZZHCS-REOHCLBHSA-N SMILES NC(CC(=O)O)C(=O)O Water Solubility 5 g/L (25 ºC) |
| Use of | L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly. Properties Articles231 Name L-aspartic acid Synonym More Synonyms L-Aspartic acid Biological Activity Description L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly. Related Catalog Natural Products >> Others Research Areas >> Cardiovascular Disease Human Endogenous Metabolite References [1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406. [2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11. Chemical & Physical Properties Molecular Formula C4H7NO4 Exact Mass 133.037506 PSA 100.62000 LogP -0.67 Index of Refraction 1.531 InChIKey CKLJMWTZIZZHCS-REOHCLBHSA-N SMILES NC(CC(=O)O)C(=O)O |
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| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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