CAS Number56-17-7
SynonymsEthanamine, 2,2'-dithiobis-, hydrochloride (1:2); CYSTAMINIUM DICHLORIDE; aed; cystaminedihcl; OYSTAMINE DIHYDROCHLORIDE; 2,2'-dithiodiethanamine dihydrochloride; 2,2'-diaminodiethyl disulfide dihydrochloride; CystamineHcl; 2,2'-Disulfanediyldiethanamine dihydrochloride; 2,2'-dithiodiethylamine dihydrocloride; cystamine 2hcl; usafcb-34; MFCD00012905; EINECS 200-260-7; 2,2'-Dithiobis[ethylamine] dihydrochloride; 2,2'-diaminoethyl disulfide dihydrochloride
Molecular FormulaNH2CH2CH2SSCH2CH2NH2 · 2HCl
Molecular Weight225.20
Purity96%
Density1.172g/cm3
Boiling Point264.8ºC at 760mmHg
Melting Point217-220 °C (dec.) (lit.)
Appearancepowder
EINECS200-260-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 56-17-7 |
| Catalog No. | 2A-9016696 |
| Chinese Name | 胱胺二盐酸盐 |
| Synonyms | Ethanamine, 2,2'-dithiobis-, hydrochloride (1:2); CYSTAMINIUM DICHLORIDE; aed; cystaminedihcl; OYSTAMINE DIHYDROCHLORIDE; 2,2'-dithiodiethanamine dihydrochloride; 2,2'-diaminodiethyl disulfide dihydrochloride; CystamineHcl; 2,2'-Disulfanediyldiethanamine dihydrochloride; 2,2'-dithiodiethylamine dihydrocloride; cystamine 2hcl; usafcb-34; MFCD00012905; EINECS 200-260-7; 2,2'-Dithiobis[ethylamine] dihydrochloride; 2,2'-diaminoethyl disulfide dihydrochloride |
| Molecular Formula | NH2CH2CH2SSCH2CH2NH2 · 2HCl |
| Molecular Weight | 225.20 |
| Purity | 96 |
| Density | 1.172g/cm3 |
| Boiling Point | 264.8ºC at 760mmHg |
| Melting Point | 217-220 °C (dec.) (lit.) |
| Appearance | powder |
| Water Solubility | soluble |
| Storage Condition | This product should be sealed and stored in a dry |
| Application | Cysteamine (dihydrochloride) is the disulfide form of free thiol cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystine also has inhibitory activity on caspase-3, with a |
| EINECS | 200-260-7 |
| HTC | 29309070 |
| PubChem ID | 24892384 |
| MDL Number | MFCD00012905 |
| SMILES | Cl[H].Cl[H].NCCSSCCN |
| InChI | 1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1H |
| InChI Key | YUFRRMZSSPQMOS-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3616850 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| Risk Codes | R22;R36/37/38 |
| Safety Description | S26;S36/37/39 |
| MSDS | msds/16696_1_56_17_7.pdf |
| Bioactivity | Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Neurological Disease Target Caspase 3:23.6 μM (IC50) In Vitro Cystamine (dihydrochloride) has inhibition activity for caspase-3 with an IC50 value of 23.6 μM[1]. Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner[1]. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione[1]. Western Blot Analysis[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 250, 500 μM Incubation Time: 0-16 h Result: Inhibited the MG132-mediated activation of caspase-3. Inhibited the H2O2-mediated activation of caspase-3. Inhibited caspase-3 activity in a tTG-independent manner. In Vivo Cystamine (dihydrochloride) (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice[2]. Animal Model: R6/2 transgenic HD mice[2] Dosage: 112, 225 mg/kg Administration: Intraperitoneal or oral, daily Result: Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels. Chemical & Physical Properties Density 1.172g/cm3 Boiling Point 264.8ºC at 760mmHg Melting Point 217-220 °C (dec.)(lit.) Molecular Formula C4H14Cl2N2S2 Molecular Weight 225.203 Exact Mass 223.997543 PSA 102.64000 LogP 3.28980 InChIKey NULDEVQACXJZLL-UHFFFAOYSA-N SMILES Cl.NCCSSCCN Stability Stable. Incompatible with strong oxidizing agents. Water Solubility soluble |
| Use of | Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [1][2][3]. Properties Articles49 Name Cystamine dihydrochloride Synonym More Synonyms Cystamine dihydrochloride Biological Activity Description Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Neurological Disease Caspase 3:23.6 μM (IC50) In Vitro Cystamine (dihydrochloride) has inhibition activity for caspase-3 with an IC50 value of 23.6 μM[1]. Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner[1]. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione[1]. Western Blot Analysis[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 250, 500 μM Incubation Time: 0-16 h Result: Inhibited the MG132-mediated activation of caspase-3. Inhibited the H2O2-mediated activation of caspase-3. Inhibited caspase-3 activity in a tTG-independent manner. Chemical & Physical Properties Exact Mass 223.997543 PSA 102.64000 LogP 3.28980 InChIKey NULDEVQACXJZLL-UHFFFAOYSA-N SMILES Cl.NCCSSCCN Stability Stable. Incompatible with strong oxidizing agents. Water Solubility soluble |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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