| Chemical & Physical Properties | |
|---|---|
| CAS Number | 78273-80-0 |
| Catalog No. | 2A-9012349 |
| Chinese Name | 罗沙替丁 |
| Synonyms | ROXATIDINE ENTERPRISE STANDARD; MFCD00871807; desacetyl-TZU-0460 |
| Molecular Formula | C17H26O3N2 |
| Molecular Weight | 306.41 |
| Purity | 98.00 |
| Density | 1.137 g/cm3 |
| Boiling Point | 524.3ºC at 760 mmHg |
| Storage Condition | 2-8°C, sealed, dry |
| Application | Roxatidine is the active metabolite of roxatidine acetate hydrochloride and is a histamine H2 receptor antagonist. The anti-ulcer drug roxatidine inhibits histamine release (and thus proton secretion) |
| HTC | 2933399090 |
| MDL Number | MFCD00871807 |
| SMILES | O=C(CO)NCCCOc1cccc(CN2CCCCC2)c1 |
| InChI | InChI=1S/C17H26N2O3.ClH/c20-14-17(21)18-8-5-11-22-16-7-4-6-15(12-16)13-19-9-2-1-3-10-19;/h4,6-7,12,20H,1-3,5,8-11,13-14H2,(H,18,21);1H |
| InChI Key | BCCREUFCSIMJFS-UHFFFAOYSA-N |
| MSDS | msds/12349_1_78273_80_0.pdf |
| Use of | Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect[1]. Properties Name Roxatidine Synonym More Synonyms Roxatidine Biological Activity Description Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect[1]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor References [1]. Lee M, et al. Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation. Sci Rep. 2017;7:41721. Published 2017 Jan 31. Chemical & Physical Properties Molecular Formula C17H26N2O3 Exact Mass 306.19400 PSA 61.80000 LogP 1.87870 InChIKey BCCREUFCSIMJFS-UHFFFAOYSA-N Safety Information HS Code 2933399090 Synthetic Route Total: 1 Page N-[3-[3-(1-Pipe... CAS#:73278-98-5 2-Acetoxyacetyl... CAS#:13831-31-7 Roxatidine CAS#:78273-80-0 Literature: Snow Brand Milk Products Co., Ltd. Patent: US5317026 A1, 1994 ; Glycolic acid CAS#:79-14-1 N-[3-[3-(1-Pipe... CAS#:73278-98-5 Roxatidine CAS#:78273-80-0 Literature: US4293557 A1, ; Precursor & DownStream Precursor 3 CAS#:73278-98-5 N-[3-[3-(1-Pipe... CAS#:13831-31-7 2-Acetoxyacetyl... CAS#:79-14-1 Glycolic acid DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Ropivacaine | 84057-95-4 | 2A-9012340 |
| Ropivacaine hydrochloride | 132112-35-7 | 2A-9012341 |
| Ropivacaine hydrochloride | 98717-15-8 | 2A-9012342 |
| Roridin A | 14729-29-4 | 2A-9012343 |
| Rottlerin | 82-08-6 | 2A-9012348 |
| Roxatidine acetate | 78628-28-1 | 2A-9012350 |
| Roxolonium metilsulfate | 53862-80-9 | 2A-9012352 |
| Rubitecan | 91421-42-0 | 2A-9012353 |
| Rubixanthin | 3763-55-1 | 2A-9012354 |
| Rubratoxinb | 21794-01-4 | 2A-9012355 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS