CAS Number78628-28-1
SynonymsRoxatidine acetate; Roxatidinum [Latin]; Pifatidine; Xarcin; 2-Oxo-2-({3-[3-(1-piperidinylmethyl)phenoxy]propyl}amino)ethyl acetate; ACETAMIDE, 2-HYDROXY-N-(3-(m-(PIPERIDINOMETHYL)PHENOXY)PROPYL)-, ACETATE (ester); Roxit; Gastralgin; Roxatidina; Roxatidinum; 2-(Acetyloxy)-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide; 2-Oxo-2-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)ethylacetat; 2-(Acetyloxy)-N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)acetamide; Altat; Roxatidina [Spanish]; MFCD00866898; Roxane; 2-Oxo-2-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)ethyl acetate; Aceroxatidine
Molecular FormulaC19H28N2O4
Molecular Weight384.9
Purity98%
Density1.1±0.1 g/cm3
Boiling Point537.3±45.0 °C at 760 mmHg
Melting Point225 °C (dec.)(lit.)
AppearanceWhite or off-white powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 78628-28-1 |
| Catalog No. | 2A-9012350 |
| Chinese Name | 醋酸罗沙替丁 |
| Synonyms | Roxatidine acetate; Roxatidinum [Latin]; Pifatidine; Xarcin; 2-Oxo-2-({3-[3-(1-piperidinylmethyl)phenoxy]propyl}amino)ethyl acetate; ACETAMIDE, 2-HYDROXY-N-(3-(m-(PIPERIDINOMETHYL)PHENOXY)PROPYL)-, ACETATE (ester); Roxit; Gastralgin; Roxatidina; Roxatidinum; 2-(Acetyloxy)-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide; 2-Oxo-2-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)ethylacetat; 2-(Acetyloxy)-N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)acetamide; Altat; Roxatidina [Spanish]; MFCD00866898; Roxane; 2-Oxo-2-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)ethyl acetate; Aceroxatidine |
| Molecular Formula | C19H28N2O4 |
| Molecular Weight | 384.9 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 537.3±45.0 °C at 760 mmHg |
| Melting Point | 225 °C (dec.)(lit.) |
| Appearance | White or off-white powder |
| Application | Roxatidine acetate is a potent, selective, competitive and orally active histamine H2 receptor antagonist. Roxatidine acetate has anti-gastric acid secretion effects. Roxatidine acetate can also inhib |
| HTC | 2933399090 |
| MDL Number | C19H29ClN2O4 |
| SMILES | CC(=O)OCC(=O)NCCCOc1cccc(CN2CCCCC2)c1 |
| InChI | InChI=1S/C19H28N2O4/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23) |
| InChI Key | SMTZFNFIKUPEJC-UHFFFAOYSA-N |
| MSDS | msds/12350_1_78628_28_1.pdf |
| Use of | Roxatidine acetate is a potent, selective, competitive and orally active histamine H2-receptor antagonist. Roxatidine acetate has antisecretory potency against gastric acid secretion. Roxatidine acetate can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine acetate has antitumor activity[1][2][3]. Properties Name [2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate Synonym More Synonyms Roxane Biological Activity Description Roxatidine acetate is a potent, selective, competitive and orally active histamine H2-receptor antagonist. Roxatidine acetate has antisecretory potency against gastric acid secretion. Roxatidine acetate can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine acetate has antitumor activity[1][2][3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor H2 Receptor References [1]. Murdoch D, et al. Roxatidine acetate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders. Drugs. 1991 Aug;42(2):240-60. [3]. Tomita K, et al. Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice. J Pharmacol Sci. 2003 Nov;93(3):321-30. [4]. Minho Lee, et al. Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation. Sci Rep. 2017 Jan 31;7:41721. Chemical & Physical Properties Molecular Formula C19H28N2O4 Exact Mass 348.204895 PSA 67.87000 Index of Refraction 1.533 InChIKey SMTZFNFIKUPEJC-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Acetamide, 2-(acetyloxy)-N-(3-(3-(1-piperidinylmethyl)phenoxy)pr opyl)- CAS REGISTRY NUMBER : 78628-28-1 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C19-H28-N2-O4 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4293557 Safety Information Hazard Codes Xn,Xi WGK Germany 3 RTECS HA1595000 HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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