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Ropivacaine hydrochloride structure, CAS 132112-35-7

Ropivacaine hydrochloride

CAS Number132112-35-7

Synonyms(S)-ROPIVACAINE HCL; (2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide; (S)-ROPIVACAINE HYDROCHLORIDE; (S)ROPIVACAINE HYDROCHLORIDE; (S)-ROPIVACAINEHYDROCHLORIDE; UNII-V910P86109; (-)-1-propyl-2',6'-dimethyl-2-piperidylcarboxyanilide; Ropivacaine; Ropivacaine hydrochloride Monohydrate; (S)ROPIVACAINE HY DROCHLORIDE; 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)-, hydrochloride, hydrate (1:1:1); S-ROPIVACAINE HCL; Ropivacaine (hydrochloride Monohydrate); (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide; (+-)-ropivacaine hydrochloride; (S)-ROPIVACAINEHCL; (S)-(-)-1-propyl-2',6'-pipecoloxylidide; S-ROPIVACAINEHCL; Ropivacainehydrochloride; Ropivacaine hydrochloride; (S)-(-)-1-propyl-2',6'-pipecoloxylidine hydrochloride monohydrate; l-N-n-Propylpipecoli

Molecular FormulaC17H29ClN2O2

Molecular Weight328.88

Purity98%

Density1.0±0.1 g/cm3

Boiling Point410.2±45.0 °C at 760 mmHg

Melting Point267-269ºC

Flash Point

Appearancewhite solid

EINECS

MSDSChineseEnglish

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Cat. No.: 2A-9012341 Purity: 98%
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Quality Control of [ 132112-35-7 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number132112-35-7
Catalog No.2A-9012341
Chinese Name盐酸罗哌卡因
Synonyms(S)-ROPIVACAINE HCL; (2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide; (S)-ROPIVACAINE HYDROCHLORIDE; (S)ROPIVACAINE HYDROCHLORIDE; (S)-ROPIVACAINEHYDROCHLORIDE; UNII-V910P86109; (-)-1-propyl-2',6'-dimethyl-2-piperidylcarboxyanilide; Ropivacaine; Ropivacaine hydrochloride Monohydrate; (S)ROPIVACAINE HY DROCHLORIDE; 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)-, hydrochloride, hydrate (1:1:1); S-ROPIVACAINE HCL; Ropivacaine (hydrochloride Monohydrate); (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide; (+-)-ropivacaine hydrochloride; (S)-ROPIVACAINEHCL; (S)-(-)-1-propyl-2',6'-pipecoloxylidide; S-ROPIVACAINEHCL; Ropivacainehydrochloride; Ropivacaine hydrochloride; (S)-(-)-1-propyl-2',6'-pipecoloxylidine hydrochloride monohydrate; l-N-n-Propylpipecoli
Molecular FormulaC17H29ClN2O2
Molecular Weight328.88
Purity98
Density1.0±0.1 g/cm3
Boiling Point410.2±45.0 °C at 760 mmHg
Melting Point267-269ºC
Appearancewhite solid
Storage ConditionRefrigerator
ApplicationRopivacaine hydrochloride blocks impulse conduction in nerve fibers and reversibly inhibits sodium ion flow.
HTC2933399090
MDL NumberC17H29ClN2O2
SMILESCCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl.O
InChIInChI=1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1
InChI KeyVSHFRHVKMYGBJL-CKUXDGONSA-N
Hazard SymbolsTransport
MSDSmsds/12341_1_132112_35_7.pdf
BioactivityRopivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.Target: Sodium ChannelRopivacaine is a new long-acting local anesthetic, with vasoconstrictive properties. Ropivacaine given epidurally provided adequate sensory anesthesia and motor block for transurethral surgery. Addition of epinephrine did not provide any significant prolongation of the sensory or motor block, nor any influence upon the sympathetic block [1]. Ropivacaine was metabolized to 2',6'-pipecoloxylidide (PPX), 3'-hydroxyropivacaine (3'-OH Rop), and 4'-hydroxyropivacaine (4'-OH Rop) by hepatic microsomes from human and rat. Ropivacaine N-dealkylation and 3'-hydroxylation activities correlated well with the level of CYP3A4 and 1A2 in human hepatic microsomes, respectively [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. Cederholm, I., S. Anskar, and M. Bengtsson, Sensory, motor, and sympathetic block during epidural analgesia with 0.5% and 0.75% ropivacaine with and without epinephrine. Reg Anesth, 1994. 19(1): p. 18-33. [2]. Oda, Y., et al., Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450. Anesthesiology, 1995. 82(1): p. 214-20. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 410.2±45.0 °C at 760 mmHg Melting Point 267-269ºC Molecular Formula C17H29ClN2O2 Molecular Weight 328.88 Flash Point 201.9±28.7 °C PSA 41.57000 LogP 3.11 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.552 InChIKey VSHFRHVKMYGBJL-CKUXDGONSA-N SMILES CCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl.O Storage condition Refrigerator
Use ofRopivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.Target: Sodium ChannelRopivacaine is a new long-acting local anesthetic, with vasoconstrictive properties. Ropivacaine given epidurally provided adequate sensory anesthesia and motor block for transurethral surgery. Addition of epinephrine did not provide any significant prolongation of the sensory or motor block, nor any influence upon the sympathetic block [1]. Ropivacaine was metabolized to 2',6'-pipecoloxylidide (PPX), 3'-hydroxyropivacaine (3'-OH Rop), and 4'-hydroxyropivacaine (4'-OH Rop) by hepatic microsomes from human and rat. Ropivacaine N-dealkylation and 3'-hydroxylation activities correlated well with the level of CYP3A4 and 1A2 in human hepatic microsomes, respectively [2]. Properties Name (S)-ropivacaine hydrochloride hydrate Synonym More Synonyms Ropivacaine hydrochloride Biological Activity Description Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.Target: Sodium ChannelRopivacaine is a new long-acting local anesthetic, with vasoconstrictive properties. Ropivacaine given epidurally provided adequate sensory anesthesia and motor block for transurethral surgery. Addition of epinephrine did not provide any significant prolongation of the sensory or motor block, nor any influence upon the sympathetic block [1]. Ropivacaine was metabolized to 2',6'-pipecoloxylidide (PPX), 3'-hydroxyropivacaine (3'-OH Rop), and 4'-hydroxyropivacaine (4'-OH Rop) by hepatic microsomes from human and rat. Ropivacaine N-dealkylation and 3'-hydroxylation activities correlated well with the level of CYP3A4 and 1A2 in human hepatic microsomes, respectively [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. Cederholm, I., S. Anskar, and M. Bengtsson, Sensory, motor, and sympathetic block during epidural analgesia with 0.5% and 0.75% ropivacaine with and without epinephrine. Reg Anesth, 1994. 19(1): p. 18-33. [2]. Oda, Y., et al., Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450. Anesthesiology, 1995. 82(1): p. 214-20. Chemical & Physical Properties PSA 41.57000 Index of Refraction 1.552 InChIKey VSHFRHVKMYGBJL-CKUXDGONSA-N Storage condition Refrigerator
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 99.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available
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