CAS Number119302-91-9
SynonymsRocuroniuM BroMide IsoMers; Rocuronium bromide; EINECS 214-776-5; Esmeron; (+)-Rocuronium bromide; Org-9426; Pyrrolidinium; Eslax; Zemuron,Esmeron; MFCD00867768; ROCURONIUN BROMIDE; Zemuron
Molecular FormulaC32H53BrN2O4
Molecular Weight609.68
Purity99.0%
Melting Point162-1640C
AppearanceWhite or off-white powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 119302-91-9 |
| Catalog No. | 2A-9012329 |
| Chinese Name | 罗库溴铵 |
| Synonyms | RocuroniuM BroMide IsoMers; Rocuronium bromide; EINECS 214-776-5; Esmeron; (+)-Rocuronium bromide; Org-9426; Pyrrolidinium; Eslax; Zemuron,Esmeron; MFCD00867768; ROCURONIUN BROMIDE; Zemuron |
| Molecular Formula | C32H53BrN2O4 |
| Molecular Weight | 609.68 |
| Purity | 99.0 |
| Melting Point | 162-1640C |
| Appearance | White or off-white powder |
| Storage Condition | Room temp |
| Application | Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular receptor inhibitor or muscle relaxant. |
| HTC | 2934999090 |
| PubChem ID | 329751056 |
| MDL Number | MFCD00867768 |
| SMILES | [Br-].CC(=O)O[C@H]1[C@H](C[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@H](C[C@]4(C)[C@H]3CC[C@]12C)N5CCOCC5)[N+]6(CCCC6)CC=C |
| InChI | 1S/C32H53N2O4.BrH/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35;/h5,23-30,36H,1,6-21H2,2-4H3;1H/q+1;/p-1/t23-,24+,25-,26-,27-,28-,29-,30-,31-,32-;/m0./s1 |
| InChI Key | OYTJKRAYGYRUJK-FMCCZJBLSA-M |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12329_1_119302_91_9.pdf |
| Bioactivity | Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.IC50 Value:in vitro: Rocuronium reduced the indirectly elicited twitch tensions in normal (50% inhibitory concentration [IC(50)], 9.84 [9.64-10.04] μM, mean [95% confidence interval]) and all pretreated diaphragms (P < .01, n = 6) in a concentration-dependent fashion [1]. The ED95 of rocuronium is essentially the same for children as for adults. Its duration of action is similar to vecuronium, and it is shorter for children than for adults. Rocuronium is readily reversed with conventional doses of cholinesterase-inhibiting drugs [2]. Onset time until maximum block, duration until 25% recovery of twitch height, and recovery from 25 until 75% of twitch height were 1.7 (32), 53 (19) and 20 (37) min, respectively [3].in vivo: Only 8.7 ± 5.7% (SD) and 6.0 ± 2.8% of an injected dose of ORG 9426 and ORG 9616 was excreted into the urine, respectively. Conversely, 54.4 ± 9.2% and 52.4 ± 9.2% of an injected dose of ORG 9426 and 35.7 ± 12.2% and 46.8 ± 9.7% of ORG 9616 were excreted into the bile in cats without and with renal pedicle ligation, respectively [4]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Narimatsu E, Niiya T, Takahashi K, Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependentfashion. Am J Emerg Med. 2012 Jul;30(6):901-7. [2]. Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8. [3]. Wierda JM, Kleef UW, Lambalk LM, The pharmacodynamics and pharmacokinetics of Org 9426, a new non-depolarizing neuromuscular blocking agent, in patients anaesthetized with nitrous oxide, halothane and fentanyl. Can J Anaesth. 1991 May;38(4 Pt 1):430-5. [4]. Khuenl-Brady K, Castagnoli KP, Canfell PC, The neuromuscular blocking effects and pharmacokinetics of ORG 9426 and ORG 9616 in the cat. Anesthesiology. 1990 Apr;72(4):669-74. Chemical & Physical Properties Melting Point 162-1640C Molecular Formula C32H53BrN2O4 Molecular Weight 609.678 Exact Mass 608.318848 PSA 59.00000 LogP 1.30820 InChIKey OYTJKRAYGYRUJK-FMCCZJBLSA-M SMILES C=CC[N+]1(C2CC3C4CCC5CC(O)C(N6CCOCC6)CC5(C)C4CCC3(C)C2OC(C)=O)CCCC1.[Br-] Storage condition Room temp |
| Use of | Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.IC50 Value:in vitro: Rocuronium reduced the indirectly elicited twitch tensions in normal (50% inhibitory concentration [IC(50)], 9.84 [9.64-10.04] μM, mean [95% confidence interval]) and all pretreated diaphragms (P < .01, n = 6) in a concentration-dependent fashion [1]. The ED95 of rocuronium is essentially the same for children as for adults. Its duration of action is similar to vecuronium, and it is shorter for children than for adults. Rocuronium is readily reversed with conventional doses of cholinesterase-inhibiting drugs [2]. Onset time until maximum block, duration until 25% recovery of twitch height, and recovery from 25 until 75% of twitch height were 1.7 (32), 53 (19) and 20 (37) min, respectively [3].in vivo: Only 8.7 ± 5.7% (SD) and 6.0 ± 2.8% of an injected dose of ORG 9426 and ORG 9616 was excreted into the urine, respectively. Conversely, 54.4 ± 9.2% and 52.4 ± 9.2% of an injected dose of ORG 9426 and 35.7 ± 12.2% and 46.8 ± 9.7% of ORG 9616 were excreted into the bile in cats without and with renal pedicle ligation, respectively [4]. Properties Articles62 Name rocuronium bromide Synonym More Synonyms Rocuronium bromide Biological Activity Description Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.IC50 Value:in vitro: Rocuronium reduced the indirectly elicited twitch tensions in normal (50% inhibitory concentration [IC(50)], 9.84 [9.64-10.04] μM, mean [95% confidence interval]) and all pretreated diaphragms (P < .01, n = 6) in a concentration-dependent fashion [1]. The ED95 of rocuronium is essentially the same for children as for adults. Its duration of action is similar to vecuronium, and it is shorter for children than for adults. Rocuronium is readily reversed with conventional doses of cholinesterase-inhibiting drugs [2]. Onset time until maximum block, duration until 25% recovery of twitch height, and recovery from 25 until 75% of twitch height were 1.7 (32), 53 (19) and 20 (37) min, respectively [3].in vivo: Only 8.7 ± 5.7% (SD) and 6.0 ± 2.8% of an injected dose of ORG 9426 and ORG 9616 was excreted into the urine, respectively. Conversely, 54.4 ± 9.2% and 52.4 ± 9.2% of an injected dose of ORG 9426 and 35.7 ± 12.2% and 46.8 ± 9.7% of ORG 9616 were excreted into the bile in cats without and with renal pedicle ligation, respectively [4]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Narimatsu E, Niiya T, Takahashi K, Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependentfashion. Am J Emerg Med. 2012 Jul;30(6):901-7. [2]. Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8. [3]. Wierda JM, Kleef UW, Lambalk LM, The pharmacodynamics and pharmacokinetics of Org 9426, a new non-depolarizing neuromuscular blocking agent, in patients anaesthetized with nitrous oxide, halothane and fentanyl. Can J Anaesth. 1991 May;38(4 Pt 1):430-5. [4]. Khuenl-Brady K, Castagnoli KP, Canfell PC, The neuromuscular blocking effects and pharmacokinetics of ORG 9426 and ORG 9616 in the cat. Anesthesiology. 1990 Apr;72(4):669-74. Chemical & Physical Properties Molecular Formula C32H53BrN2O4 Exact Mass 608.318848 PSA 59.00000 LogP 1.30820 InChIKey OYTJKRAYGYRUJK-FMCCZJBLSA-M Storage condition Room temp |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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