| Chemical & Physical Properties | |
|---|---|
| CAS Number | 87051-43-2 |
| Catalog No. | 2A-9012318 |
| Chinese Name | 利坦丝林 |
| Synonyms | Ritanserinum; Ritanserina; Ritanserine; risperidone; Tiserton |
| Molecular Formula | C27H25F2N3OS |
| Molecular Weight | 477.57 |
| Purity | 98 |
| Density | 1.3g/cm3 |
| Boiling Point | 618.7ºC at 760 mmHg |
| Appearance | powder |
| Storage Condition | Room temperature, dry |
| Application | Ritanserin (R 55667) is a highly efficient, relatively selective, orally available, long-acting 5-HT2 receptor antagonist with an IC50 value of 0.9 nM. It has weak activity on Histamine H1, Dopamine D |
| PubChem ID | 24278117 |
| MDL Number | MFCD00069341 |
| SMILES | CC1=C(CCN2CCC(\CC2)=C(\c3ccc(F)cc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1 |
| InChI | 1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3 |
| InChI Key | JUQLTPCYUFPYKE-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/12318_1_87051_43_2.pdf |
| Bioactivity | Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors[1]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Target IC50: 0.9 nM (5-HT2 receptor), 35 nM (H1 receptor), 70 nM (D2 receptor), 97 nM (α1 receptor), 150 nM (α2 receptor)[1] In Vitro Ritanserin (R 55667) is a highly potent, relatively selective, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine-H1 (IC50, 35 nM), Dopamine-D2 (IC50, 70 nM), Adrenergic-α1 (IC50, 97 nM), Adrenergic-α2 receptor (IC50, 150 nM)[1]. References [1]. Leysen JE, et al. Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist. Mol Pharmacol. 1985 Jun;27(6):600-11. Chemical & Physical Properties Density 1.3g/cm3 Boiling Point 618.7ºC at 760 mmHg Molecular Formula C27H25F2N3OS Molecular Weight 477.56900 Flash Point 328ºC Exact Mass 477.16900 PSA 65.85000 LogP 5.42090 Index of Refraction 1.646 InChIKey JUQLTPCYUFPYKE-UHFFFAOYSA-N SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 |
| Use of | Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors[1]. Properties Articles42 Name ritanserin Synonym More Synonyms Ritanserin Biological Activity Description Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors[1]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor IC50: 0.9 nM (5-HT2 receptor), 35 nM (H1 receptor), 70 nM (D2 receptor), 97 nM (α1 receptor), 150 nM (α2 receptor)[1] In Vitro Ritanserin (R 55667) is a highly potent, relatively selective, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine-H1 (IC50, 35 nM), Dopamine-D2 (IC50, 70 nM), Adrenergic-α1 (IC50, 97 nM), Adrenergic-α2 receptor (IC50, 150 nM)[1]. References [1]. Leysen JE, et al. Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist. Mol Pharmacol. 1985 Jun;27(6):600-11. Chemical & Physical Properties Molecular Formula C27H25F2N3OS Exact Mass 477.16900 PSA 65.85000 LogP 5.42090 Index of Refraction 1.646 InChIKey JUQLTPCYUFPYKE-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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