| Chemical & Physical Properties | |
|---|---|
| CAS Number | 25875-50-7 |
| Catalog No. | 2A-9012327 |
| Chinese Name | 盐酸氯苯胍 |
| Synonyms | EINECS 247-307-8; MFCD01724404; Robenidine hydrochloride |
| Molecular Formula | C15H14Cl3N5 |
| Molecular Weight | 370.66 |
| Purity | 98 |
| Boiling Point | 488.1ºC at 760 mmHg |
| Melting Point | 252-254°C |
| Appearance | off-white solid |
| Storage Condition | 0-6℃ |
| Application | Robenidine hydrochloride is an anticoccidial drug that also has inhibitory activity against MRSA and VRE, with MIC50 values of 8.1 and 4.7 μM, respectively. |
| EINECS | 247-307-8 |
| PubChem ID | 329754719 |
| MDL Number | MFCD01724404 |
| SMILES | Cl[H].Clc1ccc(cc1)\C=N\NC(=N)N\N=C\c2ccc(Cl)cc2 |
| InChI | 1S/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H,(H3,18,21,22);1H/b19-9+,20-10+; |
| InChI Key | LTWIBTYLSRDGHP-HCURTGQUSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/12327_1_25875_50_7.pdf |
| Bioactivity | Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection Target MIC50: 8.1 μM (MRSA), 4.7 μM (VRE)[1] In Vitro Robenidine (compound 1) inhibits the growth of MRSA and VRE with MIC values of 8.1 and 4.7 μM, respectively. Robenidine is bactericidal against all of the S. aureus strains tested with MBC/MIC90 ratios ≤2. A profound and negative impact on the MIC values with a 4-fold decrease with Robenidine at 2% serum and no activity at 50% serum is observed[1]. In Vivo The time that the mean plasma concentration exceeds the concentration of 1 µg/mL is approximately 6 h in the Florfenicol (FFC) alone group; however, it is lowered to 4 h by Robenidine (ROB) pretreatment. The terminal elimination half-life (t1/2z), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with Robenidine[2]. Cell Assay MRSA clinical isolates are used in this study and the MIC50 for Robenidine (compound 1) is determined using a modified MIC assay. The antimicrobial dilutions of Robenidine are completed in 100% DMSO, with 2 μL added to each well. The assay is performed in a total volume of 200 μL in 96-well plates. Robenidine is tested in final concentrations of 0.7 to 345.3 μM. Plates are incubated for 20 to 24 h at 37°C before determination of the MIC[1]. Animal Admin The rabbits are divided into four groups (n=8, each group). The rabbits in the control group are fed anticoccidial-free rations throughout the study. Rabbits in the other group are fed rations containing Robenidine (ROB) (66 ppm) for 20 consecutive days. At the end of the 20th day of feeding, a single dose of Florfenicol (FFC) is injected intravenously at 25 mg/kg body weight (b.w.) into the left auricular vein of each rabbit in all groups. Blood (approximately 1 mL) samples are collected into heparin-coated tubes from the right auricular vein of each rabbit at 5, 10, 15, 30, and 45 min and 1, 1.5, 2, 4, 6, 8, and 12 h after administration of FFC. The plasma is harvested after centrifugation at 3,000 g for 10 min and stored at -20°C until analysis[2]. References [1]. Abraham RJ, et al. Robenidine Analogues as Gram-Positive Antibacterial Agents. J Med Chem. 2016 Mar 10;59(5):2126-38. [2]. Liu C, et al. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits. Exp Anim. 2015;64(1):73-9. Chemical & Physical Properties Boiling Point 488.1ºC at 760 mmHg Melting Point 252-254°C Molecular Formula C15H14Cl3N5 Molecular Weight 370.664 Flash Point 249ºC Exact Mass 369.031494 PSA 72.63000 LogP 5.15890 Vapour Pressure 1.12E-09mmHg at 25°C InChIKey LTWIBTYLSRDGHP-HCURTGQUSA-N SMILES NC(=NN=Cc1ccc(Cl)cc1)N[NH+]=Cc1ccc(Cl)cc1.[Cl-] Storage condition 0-6°C |
| Use of | Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively. Properties Articles25 Name Robenidine Hydrochloride Synonym More Synonyms Robenidine hydrochloride Biological Activity Description Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection MIC50: 8.1 μM (MRSA), 4.7 μM (VRE)[1] In Vitro Robenidine (compound 1) inhibits the growth of MRSA and VRE with MIC values of 8.1 and 4.7 μM, respectively. Robenidine is bactericidal against all of the S. aureus strains tested with MBC/MIC90 ratios ≤2. A profound and negative impact on the MIC values with a 4-fold decrease with Robenidine at 2% serum and no activity at 50% serum is observed[1]. References [1]. Abraham RJ, et al. Robenidine Analogues as Gram-Positive Antibacterial Agents. J Med Chem. 2016 Mar 10;59(5):2126-38. [2]. Liu C, et al. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits. Exp Anim. 2015;64(1):73-9. Chemical & Physical Properties Exact Mass 369.031494 PSA 72.63000 LogP 5.15890 InChIKey LTWIBTYLSRDGHP-HCURTGQUSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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