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Ritodrine hydrochloride structure, CAS 23239-51-2

Ritodrine hydrochloride

CAS Number23239-51-2

Synonymsritodrine hcl; Pre-Pa; ritodrine(erythro); Utemerin; N-(4-Hydroxyphenethyl)-4-hydroxynorephedrine Hydrochloride; UNII-ESJ56Q60GC; Prempar; Ritodrine (hydrochloride); 4-[(1R,2S)-1-Hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol hydrochloride (1:1); pre-par; Ritodrine hydrochloride; N-(p-Hydroxyphenethyl)-4-hydroxynorephedrine hydrochloride; Miolene

Molecular FormulaC17H22ClNO3

Molecular Weight323.81

Purity99%

Density1.213 g/cm3

Boiling Point512.3ºC at 760 mmHg

Melting Point192-196ºC

Flash Point

AppearanceWhite or light white crystalline powder

EINECS245-514-8

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9012320 Purity: 99%
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Quality Control of [ 23239-51-2 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number23239-51-2
Catalog No.2A-9012320
Chinese Name盐酸利托君
Synonymsritodrine hcl; Pre-Pa; ritodrine(erythro); Utemerin; N-(4-Hydroxyphenethyl)-4-hydroxynorephedrine Hydrochloride; UNII-ESJ56Q60GC; Prempar; Ritodrine (hydrochloride); 4-[(1R,2S)-1-Hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol hydrochloride (1:1); pre-par; Ritodrine hydrochloride; N-(p-Hydroxyphenethyl)-4-hydroxynorephedrine hydrochloride; Miolene
Molecular FormulaC17H22ClNO3
Molecular Weight323.81
Purity99
Density1.213 g/cm3
Boiling Point512.3ºC at 760 mmHg
Melting Point192-196ºC
AppearanceWhite or light white crystalline powder
Storage Condition-20°C Freezer
ApplicationRitodrine hydrochloride (DU21220 hydrochloride) is a beta-2 adrenoceptor agonist.
EINECS245-514-8
PubChem ID329823511
MDL NumberMFCD01657514
SMILESCl.C[C@H](NCCc1ccc(O)cc1)[C@H](O)c2ccc(O)cc2
InChI1S/C17H21NO3.ClH/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13;/h2-9,12,17-21H,10-11H2,1H3;1H/t12-,17-;/m0./s1
InChI KeyIDLSITKDRVDKRV-XHXSRVRCSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/12320_1_23239_51_2.pdf
BioactivityRitodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.Target: β-2 Adrenergic ReceptorRitodrine is a tocolytic drug, used to stop premature labor. Ritodrine can significantly prolong a short interval more quickly but with relatively more side effects than magnesium sulphate. Stratified RCTs for different gestational ages and different labour stages should be designed for further study [1]. Ritodrine is a beta-2 adrenergic receptor agonist - a class of medication used for smooth muscle relaxation. Since ritodrine has a bulky N-substituent, it has high β2-selectivity. Also, the 4'-hydroxy on the benzene ring is important for activity as it is needed to form hydrogen bonds. However, the 4'-hydroxy makes it susceptible to metabolism by COMT. Since it is β2-selective it is used for premature labor [2]. Related Catalog Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor References [1]. Li, X., Y. Zhang, and Z. Shi, Ritodrine in the treatment of preterm labour: a meta-analysis. Indian J Med Res, 2005. 121(2): p. 120-7. [2]. Medicinal Chemistry of Adrenergics and Cholinergics Chemical & Physical Properties Density 1.213 g/cm3 Boiling Point 512.3ºC at 760 mmHg Melting Point 192-196ºC Molecular Formula C17H22ClNO3 Molecular Weight 323.815 Flash Point 175.6ºC Exact Mass 323.128815 PSA 72.72000 LogP 3.54490 Vapour Pressure 2.55E-11mmHg at 25°C InChIKey IDLSITKDRVDKRV-JSUROZADSA-N SMILES CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1.Cl Storage condition -20°C Freezer
Use ofRitodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.Target: β-2 Adrenergic ReceptorRitodrine is a tocolytic drug, used to stop premature labor. Ritodrine can significantly prolong a short interval more quickly but with relatively more side effects than magnesium sulphate. Stratified RCTs for different gestational ages and different labour stages should be designed for further study [1]. Ritodrine is a beta-2 adrenergic receptor agonist - a class of medication used for smooth muscle relaxation. Since ritodrine has a bulky N-substituent, it has high β2-selectivity. Also, the 4'-hydroxy on the benzene ring is important for activity as it is needed to form hydrogen bonds. However, the 4'-hydroxy makes it susceptible to metabolism by COMT. Since it is β2-selective it is used for premature labor [2]. Properties Name Ritodrine hydrochloride Synonym More Synonyms Ritodrine hydrochloride Biological Activity Description Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.Target: β-2 Adrenergic ReceptorRitodrine is a tocolytic drug, used to stop premature labor. Ritodrine can significantly prolong a short interval more quickly but with relatively more side effects than magnesium sulphate. Stratified RCTs for different gestational ages and different labour stages should be designed for further study [1]. Ritodrine is a beta-2 adrenergic receptor agonist - a class of medication used for smooth muscle relaxation. Since ritodrine has a bulky N-substituent, it has high β2-selectivity. Also, the 4'-hydroxy on the benzene ring is important for activity as it is needed to form hydrogen bonds. However, the 4'-hydroxy makes it susceptible to metabolism by COMT. Since it is β2-selective it is used for premature labor [2]. Related Catalog Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor References [1]. Li, X., Y. Zhang, and Z. Shi, Ritodrine in the treatment of preterm labour: a meta-analysis. Indian J Med Res, 2005. 121(2): p. 120-7. [2]. Medicinal Chemistry of Adrenergics and Cholinergics Chemical & Physical Properties Exact Mass 323.128815 PSA 72.72000 LogP 3.54490 InChIKey IDLSITKDRVDKRV-JSUROZADSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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