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Ranitidine structure, CAS 66357-35-5

Ranitidine

CAS Number66357-35-5

SynonymsTaural; Sostril; Terposen; Trigger; U1tidine; Ranitidine; Zantic; MFCD00081180; RANITIDINE USP; EINECS 266-332-5; Zantae

Molecular FormulaC13H22N4O3S

Molecular Weight350.86

Purity98%

Density1.2±0.1 g/cm3

Boiling Point437.1±45.0 °C at 760 mmHg

Melting Point69-70°C

Flash Point

Appearancewhite powder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9012267 Purity: 98%
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Quality Control of [ 66357-35-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number66357-35-5
Catalog No.2A-9012267
Chinese Name雷尼替丁
SynonymsTaural; Sostril; Terposen; Trigger; U1tidine; Ranitidine; Zantic; MFCD00081180; RANITIDINE USP; EINECS 266-332-5; Zantae
Molecular FormulaC13H22N4O3S
Molecular Weight350.86
Purity98
Density1.2±0.1 g/cm3
Boiling Point437.1±45.0 °C at 760 mmHg
Melting Point69-70°C
Appearancewhite powder
Water Solubility24.7 mg/mL
Storage ConditionDesiccate at +4°C
ApplicationRanitidine is a potent, selective, orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine is also a weak inhibitor of CYP2C19 and CYP2C9.
HTC2932999099
PubChem ID329823974
MDL NumberMFCD00069339
SMILESCl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI KeyGGWBHVILAJZWKJ-CHHCPSLASA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/12267_1_66357_35_5.pdf
Use ofProperties Name ranitidine Synonym More Synonyms Ratic Biological Activity Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Anti-infection >> Bacterial H2 Receptor:3.3 μM (IC50) References [2]. A Leucuta, et al. A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact. 2004;20(4):273-81. [3]. Antonio Francesco Ciccaglione, et al. Pylera® plus ranitidine vs Pylera® plus esomeprazole in first-line treatment of Helicobacter pylori infection: Two pilot studies. Helicobacter. 2019 Oct;24(5):e12606. Chemical & Physical Properties Molecular Formula C13H22N4O3S Exact Mass 314.141266 PSA 111.56000 Index of Refraction 1.559 Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)th io)ethyl)-N'-methyl- 2-nitro- CAS REGISTRY NUMBER : 66357-35-5 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C13-H22-N4-O3-S MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Kidney, Ureter, Bladder - interstitial nephritis Blood - other changes Skin and Appendages - dermatitis, allergic (after topical exposure) REFERENCE : AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 12,67,1994 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 25,749,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602 Safety Information WGK Germany 2 RTECS KM6557000 HS Code 2932999099 Precursor & DownStream Precursor 5 CAS#:66356-53-4 2-[([5-[(Dimeth... CAS#:7440-44-0 CAS#:13623-94-4 1-nitro-2,2-bis... CAS#:66357-07-1 N-methyl-N'-(2-... DownStream 5 CAS#:66357-59-3 Ranitidine hydr... CAS#:15433-79-1 [5-[(dimethylam... CAS#:112233-24-6 (6Z)-6-[[5-[(di... CAS#:112233-23-5 5,6-Dihydro-3-(...
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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