CAS Number117976-90-6
Synonymsnatrium-2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-id; Sodium 2-({[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl}sulfinyl)benzimidazol-1-ide; RABEPRAZOLE NA; sodium,2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]benzimidazol-1-ide; sodium 2-{[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methanesulfinyl}-1H-benzimidazol-1-ide; Pariet; Zechin; Rabonik; sodium 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-ide; Rebeprazole sodium; Aciphex; Rabeprazole Sodium Salt; Rabeprazole sodium; 2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole,Pariprazole; Sodium rabeprazole; Rabeprazole (sodium)
Molecular FormulaC18H20N3NaO3S
Molecular Weight381.42
Purity99%
Density0.45~0.55 g/ml
Boiling Point603.9ºC at 760 mmHg
Melting Point140-141ºC dec.
AppearanceWhite or off-white crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 117976-90-6 |
| Catalog No. | 2A-9012251 |
| Chinese Name | 雷贝拉唑钠 |
| Synonyms | natrium-2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-id; Sodium 2-({[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl}sulfinyl)benzimidazol-1-ide; RABEPRAZOLE NA; sodium,2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]benzimidazol-1-ide; sodium 2-{[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methanesulfinyl}-1H-benzimidazol-1-ide; Pariet; Zechin; Rabonik; sodium 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-ide; Rebeprazole sodium; Aciphex; Rabeprazole Sodium Salt; Rabeprazole sodium; 2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole,Pariprazole; Sodium rabeprazole; Rabeprazole (sodium) |
| Molecular Formula | C18H20N3NaO3S |
| Molecular Weight | 381.42 |
| Purity | 99 |
| Density | 0.45~0.55 g/ml |
| Boiling Point | 603.9ºC at 760 mmHg |
| Melting Point | 140-141ºC dec. |
| Appearance | White or off-white crystalline powder |
| Water Solubility | H2O: soluble10mg/mL (clear solution) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Application | Rabeprazole (LY307640) sodium salt is a proton pump inhibitor and can fight ulcers. |
| HTC | 2933399090 |
| SMILES | [Na+].COCCCOc1ccnc(CS(=O)c2nc3ccccc3[n-]2)c1C |
| InChI | 1S/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1 |
| InChI Key | KRCQSTCYZUOBHN-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/12251_1_117976_90_6.pdf |
| Bioactivity | Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Inflammation/Immunology References [1]. http://www.drugbank.ca/drugs/DB01129 Chemical & Physical Properties Density 0.45~0.55 g/ml Boiling Point 603.9ºC at 760 mmHg Melting Point 140-141ºC dec. Molecular Formula C18H20N3NaO3S Molecular Weight 381.424 Flash Point 319.1ºC Exact Mass 381.112305 PSA 93.41000 LogP 3.48420 InChIKey KRCQSTCYZUOBHN-UHFFFAOYSA-N SMILES COCCCOc1ccnc(CS(=O)c2nc3ccccc3[n-]2)c1C.[Na+] Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere Water Solubility H2O: soluble10mg/mL (clear solution) |
| Use of | Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds. Properties Name rabeprazole sodium Synonym More Synonyms Rabeprazole sodium Biological Activity Description Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Inflammation/Immunology References [1]. http://www.drugbank.ca/drugs/DB01129 Chemical & Physical Properties Molecular Formula C18H20N3NaO3S Exact Mass 381.112305 PSA 93.41000 LogP 3.48420 InChIKey KRCQSTCYZUOBHN-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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