EN
0
Home > Products > Pharmaceuticals & Life Science > API & Advanced Intermediates > Ramipril
Ramipril structure, CAS 87333-19-5

Ramipril

CAS Number87333-19-5

SynonymsRAMACE; UNIPRIL; PRAMACE; vesdil; DELIX; N-(1S-Carboethoxy-3-phenylpropyl)-S-alanyl-cis,endo-2-azabicyclo[3.3.0]octane-3S-carboxylic Acid; Ramipril; Trimce; HOE-498; MFCD00865775; ALTACE; CARDACE; TRITACE

Molecular FormulaC23H32N2O5

Molecular Weight416.51

Purity98%

Density1.2±0.1 g/cm3

Boiling Point616.2±55.0 °C at 760 mmHg

Melting Point106-108°C

Flash Point

Appearancewhite solid

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9012261 Purity: 98%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 87333-19-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number87333-19-5
Catalog No.2A-9012261
Chinese Name雷米普利
SynonymsRAMACE; UNIPRIL; PRAMACE; vesdil; DELIX; N-(1S-Carboethoxy-3-phenylpropyl)-S-alanyl-cis,endo-2-azabicyclo[3.3.0]octane-3S-carboxylic Acid; Ramipril; Trimce; HOE-498; MFCD00865775; ALTACE; CARDACE; TRITACE
Molecular FormulaC23H32N2O5
Molecular Weight416.51
Purity98
Density1.2±0.1 g/cm3
Boiling Point616.2±55.0 °C at 760 mmHg
Melting Point106-108°C
Appearancewhite solid
Storage Condition2-8°C
ApplicationRamipril is an ACE inhibitor with an IC50 of 5 nM.
HTC3004909090
PubChem ID329822606
MDL NumberMFCD00865775
SMILESO=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3
InChI1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
InChI KeyHDACQVRGBOVJII-JBDAPHQKSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/12261_1_87333_19_5.pdf
BioactivityRamipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.Target: ACERamipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM [1]. Ramipril enhances the activity of ACE-associated CK2 and the phosphorylation of ACE Ser1270 in cultured endothelial cells, but is unable to activate JNK or stimulate the nuclear accumulation of c-Jun in endothelial cells expressing a S1270A ACE mutant or in ACE-deficient cells. Prolonged Ramipril treatment increases ACE expression in primary cultures of human endothelial cells and in vivo (mouse lung), which can be prevented by pretreatment with the JNK inhibitor SP600125 [2].Chronic in vivo administration of Ramipril to rats at a dosage that has similar hypotensive effects in vitro HUVECs significantly reduces the rate of LPS-induced apoptosis compared to the other ACE inhibitors, which contrasts with the apoptosis effect in vitro [3]. Ramipril inhibits systolic blood pressure (SBP) with IC50 of 1.97 mg/kg in spontaneously hypertensive rats (SHR). When in combination with AT1-receptor blockade by candesartan-cilexetil increases SBP reduction synergistically rather than additively [4]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease References [1]. Raasch, W., et al., Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens, 2004. 22(3): p. 611-8. [2]. Stevens, B.R., M.I. Phillips, and A. Fernandez, Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C, 1988. 91(2): p. 493-7. [3]. Kohlstedt, K., et al., Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res, 2004. 94(1): p. 60-7. [4]. Ceconi, C., et al., Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovasc Drugs Ther, 2007. 21(6): p. 423-9. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 616.2±55.0 °C at 760 mmHg Melting Point 106-108°C Molecular Formula C23H32N2O5 Molecular Weight 416.511 Flash Point 326.4±31.5 °C Exact Mass 416.231110 PSA 95.94000 LogP 3.41 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.556 Storage condition 2-8°C
Use ofProperties Articles69 Name ramipril Synonym More Synonyms Ramipril Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease References [1]. Raasch, W., et al., Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens, 2004. 22(3): p. 611-8. [2]. Stevens, B.R., M.I. Phillips, and A. Fernandez, Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C, 1988. 91(2): p. 493-7. [3]. Kohlstedt, K., et al., Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res, 2004. 94(1): p. 60-7. [4]. Ceconi, C., et al., Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovasc Drugs Ther, 2007. 21(6): p. 423-9. Chemical & Physical Properties Molecular Formula C23H32N2O5 Exact Mass 416.231110 PSA 95.94000 Index of Refraction 1.556
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
Related Products in API & Advanced Intermediates
Quinaprilat85441-60-72A-9012231
R-(+)-Ofloxacin2A-3033332A-9012249
R(+)-Verapamil2A-3033342A-9012250
Rabeprazole Sodium117976-90-62A-9012251
Raltitrexed112887-68-02A-9012260
Ramiprilat87269-97-42A-9012262
Ranitidine 66357-35-52A-9012267
Remifentanil132875-61-72A-9012280
Ribavirin36791-04-52A-9012297
Rifabutin72559-06-92A-0201665
Browse all API & Advanced Intermediates products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA