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Quinapril hydrochloride structure, CAS 82586-55-8

Quinapril hydrochloride

CAS Number82586-55-8

SynonymsAcuitel; ccupril; Acequin; quinapril HCl; Conan; ACCUPRIN; Quinapril hydrochloride; Acupril; CI-906; Acuprel; MFCD00889215; ACCUPRO; Korec; Quinapril (hydrochloride); QuinaprilHydrochloride

Molecular FormulaC25H31ClN2O5

Molecular Weight474.98

Purity97%

Density

Boiling Point662ºC at 760 mmHg

Melting Point120-130ºC

Flash Point

AppearanceWhite crystalline solid

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9012230 Purity: 97%
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Quality Control of [ 82586-55-8 ] Purity: 97% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number82586-55-8
Catalog No.2A-9012230
Chinese Name盐酸喹那普利
SynonymsAcuitel; ccupril; Acequin; quinapril HCl; Conan; ACCUPRIN; Quinapril hydrochloride; Acupril; CI-906; Acuprel; MFCD00889215; ACCUPRO; Korec; Quinapril (hydrochloride); QuinaprilHydrochloride
Molecular FormulaC25H31ClN2O5
Molecular Weight474.98
Purity97
Boiling Point662ºC at 760 mmHg
Melting Point120-130ºC
AppearanceWhite crystalline solid
Storage Condition2-8°C
ApplicationQuinapril hydrochloride is the original drug of an angiotensin-converting enzyme (ACE) inhibitor.
MDL NumberMFCD00889215
SMILESCl.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2Cc3ccccc3C[C@H]2C(O)=O
InChI1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1
InChI KeyIBBLRJGOOANPTQ-JKVLGAQCSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/12230_1_82586_55_8.pdf
BioactivityQuinapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications.Target: ACEQuinapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure. Quinapril is rapidly de-esterified after absorption to quinaprilat (the active diacid metabolite), a potent angiotensin converting enzyme (ACE) inhibitor. Quinapril is now firmly established as an effective and well tolerated ACE inhibitor for the treatment of patients with hypertension and congestive heart failure. Quinapril 40 mg/day also significantly reduced the incidence of ischaemic events in patients undergoing CABG in one study [1, 2]. An overview of 32 clinical trials of ACE inhibitors in heart failure showed that no significant heterogeneity in mortality was found among enalapril, ramipril, quinapril, captopril, lisinopril, benazepril, perindopril and cilazapril. Initiation of therapy with captopril, ramipril, and trandolapril at least 3 days after an acute MI resulted in all-cause mortality risk reductions of 18 to 27% [3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease References [1]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24. [2]. Culy, C.R. and B. Jarvis, Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders. Drugs, 2002. 62(2): p. 339-85. [3]. Klutchko, S., et al., Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types. J Med Chem, 1986. 29(10): p. 1953-61. Chemical & Physical Properties Boiling Point 662ºC at 760 mmHg Melting Point 120-130ºC Molecular Formula C25H31ClN2O5 Molecular Weight 474.977 Flash Point 354.1ºC Exact Mass 474.192139 PSA 95.94000 LogP 3.69790 InChIKey IBBLRJGOOANPTQ-JKVLGAQCSA-N SMILES CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1Cc2ccccc2CC1C(=O)O.Cl Storage condition 2-8°C
Use ofProperties Articles32 Name quinapril hydrochloride Synonym More Synonyms Quinapril hydrochloride Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease References [1]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24. [2]. Culy, C.R. and B. Jarvis, Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders. Drugs, 2002. 62(2): p. 339-85. Chemical & Physical Properties Exact Mass 474.192139 PSA 95.94000 LogP 3.69790 InChIKey IBBLRJGOOANPTQ-JKVLGAQCSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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