CAS Number111974-69-7
Synonymsquetiapina; 2-{2-4-(dibenzob,f1,4thiazepin-11-yl)piperazin-1-ylethoxy}ethanol; 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine; MFCD08064204; Seroquel; 2-(2-(4-dibenzo[b,f][1,4]thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol; UNII-BGL0JSY5SI; 11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine; 2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol; 2-{[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethyl]oxy}ethanol; Co-Quetiapine; 2-{2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl]ethoxy}ethanol; quetiapinum; 2-{2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy}ethanol; Quetiapine [INN:BAN]; 2-(2-(4-Dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol
Molecular FormulaC21H25O2N3S1
Molecular Weight383.51
Purity98%
Density1.3±0.1 g/cm3
Boiling Point556.5±60.0 °C at 760 mmHg
Melting Point172 - 174ºC
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 111974-69-7 |
| Catalog No. | 2A-9012225 |
| Chinese Name | 喹硫平 |
| Synonyms | quetiapina; 2-{2-4-(dibenzob,f1,4thiazepin-11-yl)piperazin-1-ylethoxy}ethanol; 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine; MFCD08064204; Seroquel; 2-(2-(4-dibenzo[b,f][1,4]thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol; UNII-BGL0JSY5SI; 11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine; 2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol; 2-{[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethyl]oxy}ethanol; Co-Quetiapine; 2-{2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl]ethoxy}ethanol; quetiapinum; 2-{2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy}ethanol; Quetiapine [INN:BAN]; 2-(2-(4-Dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol |
| Molecular Formula | C21H25O2N3S1 |
| Molecular Weight | 383.51 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 556.5±60.0 °C at 760 mmHg |
| Melting Point | 172 - 174ºC |
| Appearance | White to off-white crystalline powder |
| Storage Condition | -20℃ |
| Application | Quetiapine (Ketipinor) is an atypical antipsychotic compound that can act on schizophrenia, mania and depression. |
| HTC | 2934999090 |
| MDL Number | MFCD00866699 |
| SMILES | OCCOCCN1CCN(C2=Nc3ccccc3Sc3ccccc32)CC1 |
| InChI | InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2 |
| InChI Key | URKOMYMAXPYINW-UHFFFAOYSA-N |
| MSDS | msds/12225_1_111974_69_7.pdf |
| Use of | Quetiapine(Ketipinor) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.IC50 value: Target: 5-HT ReceptorQuetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor. Properties Name quetiapine Synonym More Synonyms Quetiapine Biological Activity Description Quetiapine(Ketipinor) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.IC50 value: Target: 5-HT ReceptorQuetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease References [1]. Sheehan DV, et al. Long-term functioning and sleep quality in patients with major depressive disorder treated with extended-release quetiapine fumarate. Int Clin Psychopharmacol. 2012 Sep;27(5):239-48. [2]. Endicott J, et al. Effects of once-daily extended release quetiapine fumarate on patient-reported outcomes in patients with generalized anxiety disorder. Neuropsychiatr Dis Treat. 2012;8:301-311. [5]. Katila H, et al. Randomized, Double-Blind Study of the Efficacy and Tolerability of Extended Release Quetiapine Fumarate (Quetiapine XR) Monotherapy in Elderly Patients With Major Depressive Disorder.Am J Geriatr Psychiatry. 2012 Jun 7. Chemical & Physical Properties Molecular Formula C21H25N3O2S Exact Mass 383.166748 PSA 73.60000 Index of Refraction 1.653 InChIKey URKOMYMAXPYINW-UHFFFAOYSA-N Storage condition -20℃ Safety Information HS Code 2934999090 Synthetic Route 11-(1-Piperazin... 753475-15-9 2-(2-Chloroetho... Quetiapine 111974-69-7 11-(1-Piperazin... 2-(2-Chloroetho... Quetiapine 111974-69-7 2-(2-(4-(Dibenz... 844639-07-2 Quetiapine 111974-69-7 Precursor & DownStream Precursor 10 CAS#:753475-15-9 11-(1-Piperazin... CAS#:628-89-7 2-(2-Chloroetho... CAS#:5747-48-8 11-(1-Piperazin... CAS#:844639-07-2 2-(2-(4-(Dibenz... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Probenecid | 57-66-9 | 2A-9012127 |
| Procaine penicillin G | 54-35-3 | 2A-9012131 |
| Propranolol hydrochloride | 318-98-9 | 2A-9012171 |
| Protected Imipenem | 98367-45-4 | 2A-9012184 |
| Protected meropenem | 96036-02-1 | 2A-9012185 |
| Quinapril | 85441-61-8 | 2A-9012228 |
| Quinapril benzylester | 82586-54-7 | 2A-9012229 |
| Quinapril hydrochloride | 82586-55-8 | 2A-9012230 |
| Quinaprilat | 85441-60-7 | 2A-9012231 |
| R-(+)-Ofloxacin | 2A-303333 | 2A-9012249 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS