CAS Number318-98-9
SynonymsPropranolol hydrochloride; oposim; inderal; kemi; frekven; inderex; 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride (1:2); MFCD00012558; 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol dihydrochloride; DL-Propranolol hydrochloride; Propranolol (hydrochloride); Propranolol hyd; EINECS 206-268-7; Propranolol HCl; Propranolol; Inderal hydrochloride; inderol; deralin; tesnol; dociton
Molecular FormulaC16H22ClNO2
Molecular Weight295.80
Purity99%
Boiling Point434.9ºC at 760mmHg
Melting Point163-165 °C(lit.)
Appearanceliquid
EINECS200-659-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 318-98-9 |
| Catalog No. | 2A-9012171 |
| Chinese Name | 盐酸普萘洛尔 |
| Synonyms | Propranolol hydrochloride; oposim; inderal; kemi; frekven; inderex; 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride (1:2); MFCD00012558; 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol dihydrochloride; DL-Propranolol hydrochloride; Propranolol (hydrochloride); Propranolol hyd; EINECS 206-268-7; Propranolol HCl; Propranolol; Inderal hydrochloride; inderol; deralin; tesnol; dociton |
| Molecular Formula | C16H22ClNO2 |
| Molecular Weight | 295.80 |
| Purity | 99 |
| Boiling Point | 434.9ºC at 760mmHg |
| Melting Point | 163-165 °C(lit.) |
| Appearance | liquid |
| Water Solubility | SOLUBLE |
| Storage Condition | 2-8°C |
| Application | Propranolol hydrochloride is a non-selective β-adrenergic receptor (βAR) antagonist with an IC50 value of 12 nM. |
| EINECS | 200-659-6 |
| HTC | 2933990090 |
| SMILES | Cl.CC(C)NCC(O)COc1cccc2ccccc12 |
| InChI | 1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H |
| InChI Key | ZMRUPTIKESYGQW-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/12171_1_318_98_9.pdf |
| Bioactivity | Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist with an IC50 of 12 nM. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease Target IC50: 12 nM (βAR)[1] In Vitro In cultured endothelial or tumor cells, propranolol has been shown to both reduce cAMP levels and simultaneously activate the mitogen-activated protein kinase (MAPK) pathway downstream of βAR inhibition[2]. It displays high affinity for 5-HT1B receptors (Ki= 17 nM), and milder affinity for 5HT1D receptors (Ki= 10.2 μM)[3]. In Vivo Chronic administration of propranolol increased the beta(1)-adrenoceptors but decreased the beta(2)-adrenoceptors without changing total amount of plasma membrane beta-adrenoceptors[4]. Animal Admin Male Wistar rats weighing 250-300 g are used in the study. Propranolol is dissolved with tap water, and given ad lib. The daily consumption of propranolol is estimated to be 40 mg/kg based on a mean intake of 35 mL/day of water for a 250 g rat. The treatment period of β-adrenoceptor antagonists is changed from 1 to 3 or 6 weeks and the effects are examined[4]. References [1]. Briley M, et al. Evidence?against?beta-adrenoceptor?blocking?activity?of?diltiazem, a?drug?with?calcium?antagonistproperties. Br J Pharmacol.?1980 Aug;69(4):669-73. [2]. Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55. [3]. Glennon RA, et al. The binding of propranolol at 5-hydroxytryptamine1D beta T355N mutant receptors may involve formation of two hydrogen bonds to asparagine. Mol Pharmacol. 1996 Jan;49(1):198-206. [4]. Horinouchi T, et al. Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administrationof propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. Epub 2007 Jun 16. Chemical & Physical Properties Boiling Point 434.9ºC at 760mmHg Melting Point 163-165 °C(lit.) Molecular Formula C16H22ClNO2 Molecular Weight 332.265 Flash Point 216.8ºC Exact Mass 331.110596 PSA 41.49000 LogP 3.77040 InChIKey ZMRUPTIKESYGQW-UHFFFAOYSA-N SMILES CC(C)NCC(O)COc1cccc2ccccc12.Cl Storage condition 2-8°C Water Solubility SOLUBLE |
| Use of | Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist with an IC50 of 12 nM. Properties Articles112 Name propranolol hydrochloride Synonym More Synonyms Propranolol hydrochloride Biological Activity Description Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist with an IC50 of 12 nM. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease IC50: 12 nM (βAR)[1] In Vitro In cultured endothelial or tumor cells, propranolol has been shown to both reduce cAMP levels and simultaneously activate the mitogen-activated protein kinase (MAPK) pathway downstream of βAR inhibition[2]. It displays high affinity for 5-HT1B receptors (Ki= 17 nM), and milder affinity for 5HT1D receptors (Ki= 10.2 μM)[3]. In Vivo Chronic administration of propranolol increased the beta(1)-adrenoceptors but decreased the beta(2)-adrenoceptors without changing total amount of plasma membrane beta-adrenoceptors[4]. References [1]. Briley M, et al. Evidence?against?beta-adrenoceptor?blocking?activity?of?diltiazem, a?drug?with?calcium?antagonistproperties. Br J Pharmacol.?1980 Aug;69(4):669-73. [2]. Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55. [3]. Glennon RA, et al. The binding of propranolol at 5-hydroxytryptamine1D beta T355N mutant receptors may involve formation of two hydrogen bonds to asparagine. Mol Pharmacol. 1996 Jan;49(1):198-206. [4]. Horinouchi T, et al. Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administrationof propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. Epub 2007 Jun 16. Chemical & Physical Properties Exact Mass 331.110596 PSA 41.49000 LogP 3.77040 InChIKey ZMRUPTIKESYGQW-UHFFFAOYSA-N Water Solubility SOLUBLE |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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