CAS Number55268-74-1
SynonymsDistocide; WarMnil; embay8440; droncit; rac-praziquantel; Prazinon; Cesol; biltricide; EINECS 259-559-6; Azinox; MFCD00058531; Cysticide; pyquiton; 2-CYCLOHEXYL-CARBONYL-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRAZINE (2,1-A)ISOQUINOLINE-4-ONE
Molecular FormulaC19H24N2O2
Molecular Weight312.41
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point544.1±50.0 °C at 760 mmHg
Melting Point136-142ºC
AppearanceWhite or almost white crystalline powder
EINECS259-559-6
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 55268-74-1 |
| Catalog No. | 2A-9012104 |
| Chinese Name | 吡喹酮 |
| Synonyms | Distocide; WarMnil; embay8440; droncit; rac-praziquantel; Prazinon; Cesol; biltricide; EINECS 259-559-6; Azinox; MFCD00058531; Cysticide; pyquiton; 2-CYCLOHEXYL-CARBONYL-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRAZINE (2,1-A)ISOQUINOLINE-4-ONE |
| Molecular Formula | C19H24N2O2 |
| Molecular Weight | 312.41 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 544.1±50.0 °C at 760 mmHg |
| Melting Point | 136-142ºC |
| Appearance | White or almost white crystalline powder |
| Water Solubility | ethanol: soluble5mg/mL | Freely soluble in ethanol |
| Storage Condition | Seal and store at -20ºC |
| Application | Praziquantel has good anti-worm (flatworm) effect. |
| EINECS | 259-559-6 |
| HTC | 2933790090 |
| PubChem ID | 329823365 |
| MDL Number | MFCD00058531 |
| SMILES | O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4 |
| InChI | 1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2 |
| InChI Key | FSVJFNAIGNNGKK-UHFFFAOYSA-N |
| Beilstein/REAXYS | 761557 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12104_1_55268_74_1.pdf |
| Bioactivity | Praziquantel is an anthelmintic effective against flatworms.Target: AntiparasiticPraziquantel is the drug of choice for treatment of all human schistosomes. Infected mice were treated with increasing Praziquantel doses until the highest dose of 3 × 300 mg/Kg was reached. The effect of Praziquantel treatment on the parasite population was assessed using five polymorphic microsatellite markers. Parasitological and genetic data were compared with those of the untreated control. After six parasite generations submitted to treatment, it was possible to obtain a S. mansoni population with decreased susceptibility to Praziquantel. In our experiments we also observed that female worms were more susceptible to Praziquantel than male worms [1, 2]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Coeli, R., et al., Praziquantel treatment decreases Schistosoma mansoni genetic diversity in experimental infections. PLoS Negl Trop Dis, 2013. 7(12): p. e2596. [2]. Mekonnen, A., et al., Efficacy of Praziquantel against Schistosoma haematobium in Dulshatalo village, western Ethiopia. BMC Res Notes, 2013. 6: p. 392. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 544.1±50.0 °C at 760 mmHg Melting Point 136-142ºC Molecular Formula C19H24N2O2 Molecular Weight 312.406 Flash Point 254.6±22.5 °C Exact Mass 312.183777 PSA 40.62000 LogP 2.44 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.615 InChIKey FSVJFNAIGNNGKK-UHFFFAOYSA-N SMILES O=C(C1CCCCC1)N1CC(=O)N2CCc3ccccc3C2C1 Water Solubility ethanol: soluble5mg/mL | Freely soluble in ethanol or dichloromethane. Slightly soluble in water |
| Use of | Properties Articles117 Name Praziquantel Synonym More Synonyms Praziquantel Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Coeli, R., et al., Praziquantel treatment decreases Schistosoma mansoni genetic diversity in experimental infections. PLoS Negl Trop Dis, 2013. 7(12): p. e2596. [2]. Mekonnen, A., et al., Efficacy of Praziquantel against Schistosoma haematobium in Dulshatalo village, western Ethiopia. BMC Res Notes, 2013. 6: p. 392. Chemical & Physical Properties Molecular Formula C19H24N2O2 Exact Mass 312.183777 PSA 40.62000 Index of Refraction 1.615 InChIKey FSVJFNAIGNNGKK-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Praziquantel Modification Number: 5.3 |
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