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Pravastatin sodium structure, CAS 81131-70-6

Pravastatin sodium

CAS Number81131-70-6

SynonymsOliprevin; MFCD00887601; Vasten; 3b-Hydroxycompactin Sodium Salt; Pravastatin sodium; Pravastatin (sodium)

Molecular FormulaC23H35NaO7

Molecular Weight446.51

Purity98%

Density

Boiling Point634.5ºCat 760 mmHg

Melting Point171.2-173 °C

Flash Point

AppearanceWhite crystalline powder

EINECS

MSDSChineseEnglish

Symbol9

Signal WordWarning

Cat. No.: 2A-9012102 Purity: 98%
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Quality Control of [ 81131-70-6 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number81131-70-6
Catalog No.2A-9012102
Chinese Name普伐他汀钠
SynonymsOliprevin; MFCD00887601; Vasten; 3b-Hydroxycompactin Sodium Salt; Pravastatin sodium; Pravastatin (sodium)
Molecular FormulaC23H35NaO7
Molecular Weight446.51
Purity98
Boiling Point634.5ºCat 760 mmHg
Melting Point171.2-173 °C
AppearanceWhite crystalline powder
Water SolubilityH2O: 19 mg/mL
Storage ConditionDry, airtight, refrigerated at 2-10°C
PackagingIII
ApplicationPravastatin is an HMG-CoA reductase inhibitor with an IC50 of 5.6 μM for sterol synthesis.
HTC2932999099
SMILES[Na+].[O-]C(=O)C[C@H](O)C[C@H](O)CC[C@@H]1[C@H]2[C@H](C[C@@H](C=C2C=C[C@@H]1C)O)OC(=O)[C@H](CC)C
InChI1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
InChI KeyVWBQYTRBTXKKOG-IYNICTALSA-M
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbols9
MSDSmsds/12102_1_81131_70_6.pdf
BioactivityPravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.Target: HMG-CoA reductasePravastatin (marketed as Pravachol or Selektine) is a member of the drug class of statins, used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease.Pravastatin is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. It is recommended to be used only after other measures such as diet, exercise, and weight reduction have not improved cholesterol levels.The evidence for the use of pravastatin is generally weaker than for other statins. The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT), failed to demonstrate a difference in all-cause mortality or nonfatal myocardial infarction/fatal coronary heart disease rates between patients receiving pravastatin 40mg daily (a common starting dose) and those receiving usual care. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Cardiovascular Disease References [1]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89. Chemical & Physical Properties Boiling Point 634.5ºCat 760 mmHg Melting Point 171.2-173 °C Molecular Formula C23H35NaO7 Molecular Weight 446.51 Flash Point 213.2ºC PSA 124.29000 LogP 2.44040 InChIKey VWBQYTRBTXKKOG-IYNICTALSA-M SMILES CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC(O)CC(O)CC(=O)[O-])C21.[Na+] Storage condition 2-8°C Water Solubility H2O: 19 mg/mL
Use ofProperties Name pravastatin sodium Synonym More Synonyms Pravastatin (sodium) Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Cardiovascular Disease References [1]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89. Chemical & Physical Properties Molecular Formula C23H35NaO7 PSA 124.29000 LogP 2.44040 InChIKey VWBQYTRBTXKKOG-IYNICTALSA-M
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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