CAS Number14222-60-7
Synonyms2-propylpyridine-4-carbothioamide; EINECS 238-093-7; protionamide; 2-Propyl-4-pyridinecarbothioamide; Propylthioisonicotinamide; Prothionamide; MFCD00464119
Molecular FormulaC9H12N2S
Molecular Weight180.27
Purity≥99 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point310.4±44.0 °C at 760 mmHg
Melting Point140ºC
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 14222-60-7 |
| Catalog No. | 2A-9012187 |
| Chinese Name | 丙硫异烟胺 |
| Synonyms | 2-propylpyridine-4-carbothioamide; EINECS 238-093-7; protionamide; 2-Propyl-4-pyridinecarbothioamide; Propylthioisonicotinamide; Prothionamide; MFCD00464119 |
| Molecular Formula | C9H12N2S |
| Molecular Weight | 180.27 |
| Purity | ≥99 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 310.4±44.0 °C at 760 mmHg |
| Melting Point | 140ºC |
| Appearance | powder |
| Water Solubility | Water solubility: insoluble; easily soluble in: me |
| Storage Condition | Refrigerator |
| Application | Protionamide (prothionamide) acts on tuberculosis and leprosy. |
| HTC | 2933399090 |
| PubChem ID | 329824982 |
| MDL Number | MFCD00464119 |
| SMILES | NC(C1=CC(CCC)=NC=C1)=S |
| InChI | 1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12) |
| InChI Key | VRDIULHPQTYCLN-UHFFFAOYSA-N |
| NACRES Code | NA.85 |
| UNSPSC | 51102829 |
| MSDS | msds/12187_1_14222_60_7.pdf |
| Bioactivity | Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis; has also been tested for use in the treatment of leprosy.Target: Anti tuberculosisAlthough ETH and PTH are both potent drugs against M. tuberculosis (MIC = ～0.5 μg/ml) (24), they do not affect E. coli growth, even at very high concentrations (100 μg/ml), which is primarily caused by the absence of an EthA homologue in E. coli [1]. Clinical improvement was noted in 74% of the patients treated with ethionamide and in 83% of those treated with prothionamide. Therapy was well tolerated and drug-related hepatotoxicity did not require discontinuation of therapy. The 500-mg dose of both ethionamide and prothionamide resulted in loss in Mycobacterium leprae viability more rapidly than did the 250-mg dose, and prothionamide at both dose levels was superior to the equivalent dose of ethionamide [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Wang F, et al. Mechanism of thioamide drug action against tuberculosis and leprosy.J Exp Med. 2007 Jan 22;204(1):73-8. [2]. Fajardo TT, et al. A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy. Am J Trop Med Hyg. 2006 Mar;74(3):457-61. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 310.4±44.0 °C at 760 mmHg Melting Point 140ºC Molecular Formula C9H12N2S Molecular Weight 180.270 Flash Point 141.5±28.4 °C Exact Mass 180.072113 PSA 71.00000 LogP 1.75 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.607 InChIKey VRDIULHPQTYCLN-UHFFFAOYSA-N SMILES CCCc1cc(C(N)=S)ccn1 Storage condition Refrigerator |
| Use of | Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis; has also been tested for use in the treatment of leprosy.Target: Anti tuberculosisAlthough ETH and PTH are both potent drugs against M. tuberculosis (MIC = ～0.5 μg/ml) (24), they do not affect E. coli growth, even at very high concentrations (100 μg/ml), which is primarily caused by the absence of an EthA homologue in E. coli [1]. Clinical improvement was noted in 74% of the patients treated with ethionamide and in 83% of those treated with prothionamide. Therapy was well tolerated and drug-related hepatotoxicity did not require discontinuation of therapy. The 500-mg dose of both ethionamide and prothionamide resulted in loss in Mycobacterium leprae viability more rapidly than did the 250-mg dose, and prothionamide at both dose levels was superior to the equivalent dose of ethionamide [2]. Properties Name 2-Propylpyridine-4-carbothioamide Synonym More Synonyms protionamide Biological Activity Description Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis; has also been tested for use in the treatment of leprosy.Target: Anti tuberculosisAlthough ETH and PTH are both potent drugs against M. tuberculosis (MIC = ～0.5 μg/ml) (24), they do not affect E. coli growth, even at very high concentrations (100 μg/ml), which is primarily caused by the absence of an EthA homologue in E. coli [1]. Clinical improvement was noted in 74% of the patients treated with ethionamide and in 83% of those treated with prothionamide. Therapy was well tolerated and drug-related hepatotoxicity did not require discontinuation of therapy. The 500-mg dose of both ethionamide and prothionamide resulted in loss in Mycobacterium leprae viability more rapidly than did the 250-mg dose, and prothionamide at both dose levels was superior to the equivalent dose of ethionamide [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Wang F, et al. Mechanism of thioamide drug action against tuberculosis and leprosy.J Exp Med. 2007 Jan 22;204(1):73-8. [2]. Fajardo TT, et al. A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy. Am J Trop Med Hyg. 2006 Mar;74(3):457-61. Chemical & Physical Properties Molecular Formula C9H12N2S Exact Mass 180.072113 PSA 71.00000 Index of Refraction 1.607 InChIKey VRDIULHPQTYCLN-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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