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Prostaglandin D2 structure, CAS 41598-07-6

Prostaglandin D2

CAS Number41598-07-6

SynonymsPGD2; (5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid; Prostaglandin D2; (5Z,9α,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oic acid; MFCD00077857

Molecular FormulaC20H32O5

Molecular Weight352.47

Purity≥98 (HPLC)%

Density1.1±0.1 g/cm3

Boiling Point549.6±50.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9012179 Purity: ≥98 (HPLC)%
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Quality Control of [ 41598-07-6 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number41598-07-6
Catalog No.2A-9012179
Chinese Name前列腺素 D2
SynonymsPGD2; (5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid; Prostaglandin D2; (5Z,9α,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oic acid; MFCD00077857
Molecular FormulaC20H32O5
Molecular Weight352.47
Purity≥98 (HPLC)
Density1.1±0.1 g/cm3
Boiling Point549.6±50.0 °C at 760 mmHg
Appearancesolid
Storage ConditionSealed with argon and stored dry below 0 ºC
ApplicationProstaglandin D2 (PGD2) is one of the major prostaglandins actively produced in the brains of various mammals. Prostaglandin D2 is one of the most potent endogenous sleep promoters. Prostaglandin D2 p
MDL NumberMFCD00077857
SMILESO[C@@H]1[C@@H]([C@H](C(=O)C1)\C=C\[C@@H](O)CCCCC)C\C=C/CCCC(=O)O
InChI1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1
InChI KeyBHMBVRSPMRCCGG-OUTUXVNYSA-N
NACRES CodeNA.77
eCl@ss42020658
UNSPSC12352211
Hazard SymbolsTransport
MSDSmsds/12179_1_41598_07_6.pdf
BioactivityProstaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3]. Related Catalog Research Areas >> Inflammation/Immunology Target Human Endogenous Metabolite In Vivo Prostaglandin D2 (PGD2; infused into the lateral ventricle; 5-50 pmol/min; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice[2]. Animal Model: Male WT and A2AR KO mice of the inbred C57BL/6 strain (weighing 23-27 g, 11-13 weeks old)[1] Dosage: 5, 10, 20, or 50 pmol/min Administration: Infused into the lateral ventricle; for 6 hours between 20:00 and 2:00 Result: Induced sleep-wake profiles. References [1]. Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385(2):321-8. [2]. Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38(4):469-476. [3]. Kida T, et al. Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11(12):e0167729. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 549.6±50.0 °C at 760 mmHg Molecular Formula C20H32O5 Molecular Weight 352.465 Flash Point 300.3±26.6 °C Exact Mass 352.224976 PSA 94.83000 LogP 2.02 Vapour Pressure 0.0±3.4 mmHg at 25°C Index of Refraction 1.561 InChIKey BHMBVRSPMRCCGG-OUTUXVNYSA-N SMILES CCCCCC(O)C=CC1C(=O)CC(O)C1CC=CCCCC(=O)O Storage condition 20°C
Use ofProstaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3]. Properties Articles143 Name prostaglandin D2 Synonym More Synonyms Prostaglandin D2 Biological Activity Description Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3]. Related Catalog Research Areas >> Inflammation/Immunology Human Endogenous Metabolite References [1]. Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385(2):321-8. [2]. Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38(4):469-476. [3]. Kida T, et al. Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11(12):e0167729. Chemical & Physical Properties Molecular Formula C20H32O5 Exact Mass 352.224976 PSA 94.83000 Index of Refraction 1.561 InChIKey BHMBVRSPMRCCGG-OUTUXVNYSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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