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Proscillaridin A structure, CAS 466-06-8

Proscillaridin A

CAS Number466-06-8

SynonymsProtasin; 14-Hydroxy-3b-(rhamnosyloxy)bufa-4,20,22-trienolide; (3β)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolid; Scillarenin 3β-rhamnoside; 3-β-((6-Deoxy-α-L-mannopyranosyl)oxy)-14-hydroxybufa-4,20,22-trienolide; Desgluco-transvaalin; Urgilan; Herzo proscillan; Scillarenin 3b-Rhamnoside; Scillarenin 3a-L-Rhamnopyranoside; 3b-Rhamnosido-14b-hydroxy-D4,20,22-bufatrienolide; Proscillaridin; Scillacrist; Desglucotransvaaline; Coratol; Scilla "didier"; (3β)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide; Purosin-TC; Sandoscill; Wirnesin; Caratol; (3b)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide; 3b-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide; Tradenal; Herzo; psc-801; Caradrin; Cardion; 14-Hydroxy-

Molecular FormulaC30H42O8

Molecular Weight530.65

Purity≥90 (HPLC)%

Density1.3±0.1 g/cm3

Boiling Point716.7±60.0 °C at 760 mmHg

Melting Point233ºC

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9012176 Purity: ≥90 (HPLC)%
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Quality Control of [ 466-06-8 ] Purity: ≥90 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number466-06-8
Catalog No.2A-9012176
Chinese Name原海葱甙A
SynonymsProtasin; 14-Hydroxy-3b-(rhamnosyloxy)bufa-4,20,22-trienolide; (3β)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolid; Scillarenin 3β-rhamnoside; 3-β-((6-Deoxy-α-L-mannopyranosyl)oxy)-14-hydroxybufa-4,20,22-trienolide; Desgluco-transvaalin; Urgilan; Herzo proscillan; Scillarenin 3b-Rhamnoside; Scillarenin 3a-L-Rhamnopyranoside; 3b-Rhamnosido-14b-hydroxy-D4,20,22-bufatrienolide; Proscillaridin; Scillacrist; Desglucotransvaaline; Coratol; Scilla "didier"; (3β)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide; Purosin-TC; Sandoscill; Wirnesin; Caratol; (3b)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide; 3b-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide; Tradenal; Herzo; psc-801; Caradrin; Cardion; 14-Hydroxy-
Molecular FormulaC30H42O8
Molecular Weight530.65
Purity≥90 (HPLC)
Density1.3±0.1 g/cm3
Boiling Point716.7±60.0 °C at 760 mmHg
Melting Point233ºC
Appearancepowder
Storage Condition2-8℃
ApplicationProscillaridin A is a potent inhibitor of topoisomerase I and II topoisomerase I/II, with IC50 values ​​of 30 nM and 100 nM for inhibiting topoisomerase I and II, respectively.
MDL NumberMFCD00214065
SMILESC[C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O[C@]5([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)C=C4CC[C@@]3([H])[C@@]1(O)CC[C@@H]2C6=COC(C=C6)=O
InChI1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19?,20?,21?,22?,24-,25+,26+,27-,28?,29?,30?/m0/s1
InChI KeyMYEJFUXQJGHEQK-RLQJMXQZSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard SymbolsTransport
MSDSmsds/12176_1_466_06_8.pdf
BioactivityProscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Target Topoisomerase I:30 nM (IC50) Topoisomerase II:100 nM (IC50) In Vitro Proscillaridin A (0-160 nM; 48 hours) reveals the antiproliferative response in a time- as well as dose-dependent manner in MCF-7 cells[1]. References [1]. Bielawski K, et al. Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A.Biol Pharm Bull. 2006 Jul;29(7):1493-7. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 716.7±60.0 °C at 760 mmHg Melting Point 233ºC Molecular Formula C30H42O8 Molecular Weight 530.650 Flash Point 232.6±26.4 °C Exact Mass 530.287964 PSA 129.59000 LogP 3.90 Vapour Pressure 0.0±5.2 mmHg at 25°C Index of Refraction 1.620 Storage condition 2-8℃
Use ofProscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively[1]. Properties Articles25 Name Proscillaridin A Synonym More Synonyms Proscillaridin A Biological Activity Description Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Topoisomerase I:30 nM (IC50) Topoisomerase II:100 nM (IC50) References Chemical & Physical Properties Molecular Formula C30H42O8 Exact Mass 530.287964 PSA 129.59000 Index of Refraction 1.620 Storage condition 2-8℃
Transport InfoProduct name: Purity: 80.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Proscillaridin) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Proscillaridin) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Proscillaridin) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available
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