CAS Number745-65-3
SynonymsEINECS 212-017-2; ProstaglandinE1; Minprog; Prostaglandine E; PGE1; PegE1; Prostaglandin E1; Palux; Liple; (1R,2R,3R)-3-Hydroxy-2-((E)-(3S)-3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid; 7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl}heptanoic acid; alprostadil; (11a,13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid; (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid; ONO 1608; MFCD00077860; (11a,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic Acid; PGEl; Caverject; l-pge1
Molecular FormulaC20H34O5
Molecular Weight354.48
Purity≥98 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point529.3±50.0 °C at 760 mmHg
Melting Point115-116 °C
Appearance(powder to crystals)
EINECS212-017-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 745-65-3 |
| Catalog No. | 2A-9012180 |
| Chinese Name | 列腺素 E1 |
| Synonyms | EINECS 212-017-2; ProstaglandinE1; Minprog; Prostaglandine E; PGE1; PegE1; Prostaglandin E1; Palux; Liple; (1R,2R,3R)-3-Hydroxy-2-((E)-(3S)-3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid; 7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl}heptanoic acid; alprostadil; (11a,13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid; (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid; ONO 1608; MFCD00077860; (11a,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic Acid; PGEl; Caverject; l-pge1 |
| Molecular Formula | C20H34O5 |
| Molecular Weight | 354.48 |
| Purity | ≥98 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 529.3±50.0 °C at 760 mmHg |
| Melting Point | 115-116 °C |
| Appearance | (powder to crystals) |
| Water Solubility | Insoluble |
| Storage Condition | Store at -20℃ |
| Packaging | III |
| Application | Prostaglandin E1 (PGE1) is a potent vasodilator and activates prostaglandin E1 (prostaglandin E1 (EP)) receptors. |
| EINECS | 212-017-2 |
| HTC | 29375000 |
| PubChem ID | 57654538 |
| MDL Number | MFCD00077860 |
| SMILES | O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1 |
| InChI | 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1 |
| InChI Key | GMVPRGQOIOIIMI-DWKJAMRDSA-N |
| Beilstein/REAXYS | 5294062 |
| NACRES Code | NA.77 |
| eCl@ss | 42020658 |
| UNSPSC | 12352211 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/12180_1_745_65_3.pdf |
| Bioactivity | Prostaglandin E1 (PGE1) is a potent vasodilator and activates the prostaglandin E1 (EP) receptor. Related Catalog Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Metabolic Disease Natural Products >> Others Target Human Endogenous Metabolite References [1]. Cawello W, et al. Dose proportional pharmacokinetics of alprostadil (prostaglandin E1) in healthy volunteers following intravenous infusion. Br J Clin Pharmacol. 1995 Sep;40(3):273-6. [2]. Roehl SL, et al. Alprostadil (Prostin VR Pediatric Sterile Solution, The Upjohn Company). Drug Intell Clin Pharm. 1982 Nov;16(11):823-32. [3]. Harding LM, et al. Comparison of a needle-free high-pressure injection system with needle-tipped injection of intracavernosal alprostadil for erectile dysfunction. Int J Impot Res. 2002 Dec;14(6):498-501. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 529.3±50.0 °C at 760 mmHg Melting Point 115-116 °C Molecular Formula C20H34O5 Molecular Weight 354.481 Flash Point 288.0±26.6 °C Exact Mass 354.240631 PSA 94.83000 LogP 2.24 Vapour Pressure 0.0±3.2 mmHg at 25°C Index of Refraction 1.546 InChIKey GMVPRGQOIOIIMI-DWKJAMRDSA-N SMILES CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(=O)O Storage condition -20℃ |
| Use of | Prostaglandin E1 (PGE1) is a potent vasodilator and activates the prostaglandin E1 (EP) receptor. Properties Articles120 Name prostaglandin E1 Synonym More Synonyms Prostaglandin E1 Biological Activity Description Prostaglandin E1 (PGE1) is a potent vasodilator and activates the prostaglandin E1 (EP) receptor. Related Catalog Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Metabolic Disease Natural Products >> Others Human Endogenous Metabolite References [1]. Cawello W, et al. Dose proportional pharmacokinetics of alprostadil (prostaglandin E1) in healthy volunteers following intravenous infusion. Br J Clin Pharmacol. 1995 Sep;40(3):273-6. [2]. Roehl SL, et al. Alprostadil (Prostin VR Pediatric Sterile Solution, The Upjohn Company). Drug Intell Clin Pharm. 1982 Nov;16(11):823-32. [3]. Harding LM, et al. Comparison of a needle-free high-pressure injection system with needle-tipped injection of intracavernosal alprostadil for erectile dysfunction. Int J Impot Res. 2002 Dec;14(6):498-501. Chemical & Physical Properties Molecular Formula C20H34O5 Exact Mass 354.240631 PSA 94.83000 Index of Refraction 1.546 InChIKey GMVPRGQOIOIIMI-DWKJAMRDSA-N Storage condition -20℃ |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Alprostadil) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Alprostadil) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Alprostadil) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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