CAS Number363-24-6
Synonyms(Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid; (-)-Prostaglandin E2; (5Z,11a,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid; Prostaglandin,PGE2; Dinoprostone; Prostaglandin E2; EINECS 206-656-6; Prepidil; Prostin E2; MFCD00077861; l-pge2; Cervidil(R); PGE2; Cerviprost; ProstaglandinE2; (5Z)-7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl}hept-5-enoic acid; prostin; Propess; Minprostin E2; MCH (human,mouse,rat); Cervidil; (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid; prostine2; Prostenon
Molecular FormulaC20H32O5
Molecular Weight352.47
Purity≥93 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point530.1±50.0 °C at 760 mmHg
Melting Point66-68 °C
Appearancepowder
EINECS206-656-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 363-24-6 |
| Catalog No. | 2A-9012181 |
| Chinese Name | 地诺前列酮 |
| Synonyms | (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid; (-)-Prostaglandin E2; (5Z,11a,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid; Prostaglandin,PGE2; Dinoprostone; Prostaglandin E2; EINECS 206-656-6; Prepidil; Prostin E2; MFCD00077861; l-pge2; Cervidil(R); PGE2; Cerviprost; ProstaglandinE2; (5Z)-7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl}hept-5-enoic acid; prostin; Propess; Minprostin E2; MCH (human,mouse,rat); Cervidil; (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid; prostine2; Prostenon |
| Molecular Formula | C20H32O5 |
| Molecular Weight | 352.47 |
| Purity | ≥93 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 530.1±50.0 °C at 760 mmHg |
| Melting Point | 66-68 °C |
| Appearance | powder |
| Water Solubility | insoluble |
| Storage Condition | Store at -20°. |
| Application | Prostaglandin E2 is a hormone-like substance involved in a wide range of body functions, such as the contraction and relaxation of smooth muscles, the dilation and contraction of blood vessels, the co |
| EINECS | 206-656-6 |
| PubChem ID | 24898100 |
| MDL Number | MFCD00077861 |
| SMILES | O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O |
| InChI | 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 |
| InChI Key | XEYBRNLFEZDVAW-ARSRFYASSA-N |
| Beilstein/REAXYS | 4709356 |
| NACRES Code | NA.77 |
| eCl@ss | 42020658 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/12181_1_363_24_6.pdf |
| Bioactivity | Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. Related Catalog Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Natural Products >> Acids and Aldehydes Research Areas >> Cardiovascular Disease Target EP2 Receptor Human Endogenous Metabolite In Vitro PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation[1]. In Vivo PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats[2]. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction[3]. Cell Assay Lymphocytes in CM (1×106 cells/mL) are ditributed in microculture plates (100 μL) in triplicate in the presence of PGE-treated T cells or medium-treated T cells and stimulated with PHA-P at various mitogenic doses. After 72 hr, cultures are pulsed with 1 μCi [3H]thymidine per well (specific activity 5 Ci/mM) for 16 to 18 hr, collected with amicroprecipltator, dried, and counted in a liquid scintillation counter. Animal Admin Male Sprague Dawley rats (200-250 g) are used throughout the study. For 3 consecutive days rats in the experimental groups receive a daily intraperitoneal injection of either PGE2 (0.3 μg/kg body weight (BW)), the prostaglandin inhibitor mecbofenamate (10 mg/kg BW) or the prostaglandin precursor arachidonic acid (0.3 μg/ kg BW). To determine whether or not 0.3 μg/kg BW of a fatty acid produces nonspecific effects, the biologically inactive fatty acid 11, 14, 17-eicosatrienoic acid is also administered to a group of rats. Rats in the control group receive an equivalent volume (2.0 mL/kg BW) of the vehicle. On the third day, 3 mL of a suspension containing 1.2×106 fluorescent methacrylate microbeads/mL of PBS are injected intraperitoneally (ip) into each rat. Six hours later all animals are given ip a regular dose of their respective treatment. Peritoneal exudate cells are harvested 19-22 hr later. References [1]. Chouaib S, et al. The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes. J Immunol. 1984 Apr;132(4):1851-7. [2]. Fernandez-Repollet E, et al. In vivo effects of prostaglandin E2 and arachidonic acid on phagocytosis of fluorescent methacrylate microbeads by rat peritoneal macrophages. J Histochem Cytochem. 1982 May;30(5):466-70. [3]. Haylor J, et al. Renal vasodilator activity of prostaglandin E2 in the rat anaesthetized with pentobarbitone. Br J Pharmacol. 1982 May;76(1):131-7. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 530.1±50.0 °C at 760 mmHg Melting Point 66-68 °C Molecular Formula C20H32O5 Molecular Weight 352.465 Flash Point 288.5±26.6 °C Exact Mass 352.224976 PSA 94.83000 LogP 1.88 Vapour Pressure 0.0±3.2 mmHg at 25°C Index of Refraction 1.561 InChIKey XEYBRNLFEZDVAW-ARSRFYASSA-N SMILES CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(=O)O Water Solubility insoluble |
| Use of | Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. Properties Articles898 Name prostaglandin E2 Synonym More Synonyms Dinoprostone Biological Activity Description Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. Related Catalog Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Natural Products >> Acids and Aldehydes Research Areas >> Cardiovascular Disease EP2 Receptor Human Endogenous Metabolite In Vitro PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation[1]. References [1]. Chouaib S, et al. The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes. J Immunol. 1984 Apr;132(4):1851-7. [2]. Fernandez-Repollet E, et al. In vivo effects of prostaglandin E2 and arachidonic acid on phagocytosis of fluorescent methacrylate microbeads by rat peritoneal macrophages. J Histochem Cytochem. 1982 May;30(5):466-70. [3]. Haylor J, et al. Renal vasodilator activity of prostaglandin E2 in the rat anaesthetized with pentobarbitone. Br J Pharmacol. 1982 May;76(1):131-7. Chemical & Physical Properties Molecular Formula C20H32O5 Exact Mass 352.224976 PSA 94.83000 Index of Refraction 1.561 InChIKey XEYBRNLFEZDVAW-ARSRFYASSA-N Water Solubility insoluble |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Proscillaridin A | 466-06-8 | 2A-9012176 |
| Prostaglandin A1 | 14152-28-4 | 2A-9012177 |
| Prostaglandin A2 | 13345-50-1 | 2A-9012178 |
| Prostaglandin D2 | 41598-07-6 | 2A-9012179 |
| Prostaglandin E1 | 745-65-3 | 2A-9012180 |
| Prostaglandin F1alpha | 745-62-0 | 2A-0201576 |
| Prostalene | 54120-61-5 | 2A-9012183 |
| Prothionamide | 14222-60-7 | 2A-9012187 |
| Prothoate | 2275-18-5 | 2A-9012188 |
| Protodioscin | 55056-80-9 | 2A-9012189 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS