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Proxyphyllin structure, CAS 603-00-9

Proxyphyllin

CAS Number603-00-9

SynonymsMFCD00022833; 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione; (1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine); EINECS 210-028-7; Proxyphylline; 7-(2-Hydroxypropyl)theophylline

Molecular FormulaC10H14N4O3

Molecular Weight238.248

Purity98%

Density1.46 g/cm3

Boiling Point487.2ºC

Melting Point134-136ºC

Flash Point

AppearanceSolid;White to Almost white powder to crystal

EINECS

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Cat. No.: 2A-9012191 Purity: 98%
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Quality Control of [ 603-00-9 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number603-00-9
Catalog No.2A-9012191
Chinese Name7-(2-羟丙基)茶碱
SynonymsMFCD00022833; 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione; (1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine); EINECS 210-028-7; Proxyphylline; 7-(2-Hydroxypropyl)theophylline
Molecular FormulaC10H14N4O3
Molecular Weight238.248
Purity98
Density1.46 g/cm3
Boiling Point487.2ºC
Melting Point134-136ºC
AppearanceSolid;White to Almost white powder to crystal
Water SolubilityWater solubility: completely soluble; soluble in:
Storage ConditionRefrigerator
ApplicationProxyphylline is a methylxanthine derivative used clinically as a cardiac stimulant, vasodilator and bronchodilator.
HTC2939590000
MDL NumberMFCD00022833
SMILESCC(O)Cn1cnc2c1c(=O)n(C)c(=O)n2C
InChIInChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3
InChI KeyKYHQZNGJUGFTGR-UHFFFAOYSA-N
Hazard SymbolsTransport
MSDSmsds/12191_1_603_00_9.pdf
BioactivityProxyphylline is a methylxanthine derivative clinical used as cardiac stimulant, vasodilator and bronchodilator. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Cardiovascular Disease In Vitro Proxyphylline has shown vasodilatory and cardiac stimulatory effects. Proxyphylline produces an increase in the coronary flow associated with a definite positive inotropic effect[1]. Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline[2] In Vivo In a double-blind cross-over study, proxyphylline exhibits bronchodilatory effect[3]. Proxyphylline inhibits cAMP and cGMP hydrolysis in human lung tissue. The apparent inhibition constant of proxyphylline is 0.06-0.7 mM at low cAMP concentrations and it is 1.0 mM at high cAMP concentrations[3]. References [1]. Takeda K, et al. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture(theoesberiven) on the heart and the coronary circulation. Jpn J Pharmacol. 1977 Oct;27(5):709-20. [2]. Kukovetz WR, et al. Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation. Arzneimittelforschung. 1983;33(10):1450-4. [3]. Rasmussen FV, et al. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. Eur J Respir Dis. 1984 Jan;65(1):20-7. [4]. Selvig K, et al. Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):250-2. Chemical & Physical Properties Density 1.46 g/cm3 Boiling Point 487.2ºC Melting Point 134-136ºC Molecular Formula C10H14N4O3 Molecular Weight 238.24300 Flash Point 248.5ºC Exact Mass 238.10700 PSA 82.05000 Index of Refraction 1.664 InChIKey KYHQZNGJUGFTGR-UHFFFAOYSA-N SMILES CC(O)Cn1cnc2c1c(=O)n(C)c(=O)n2C Storage condition Refrigerator
Use ofProxyphylline is a methylxanthine derivative clinical used as cardiac stimulant, vasodilator and bronchodilator. Properties Articles26 Name 7-(β-Hydroxypropyl)theophylline Synonym More Synonyms Proxyphylline Biological Activity Description Proxyphylline is a methylxanthine derivative clinical used as cardiac stimulant, vasodilator and bronchodilator. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Cardiovascular Disease In Vitro Proxyphylline has shown vasodilatory and cardiac stimulatory effects. Proxyphylline produces an increase in the coronary flow associated with a definite positive inotropic effect[1]. Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline[2] References [1]. Takeda K, et al. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture(theoesberiven) on the heart and the coronary circulation. Jpn J Pharmacol. 1977 Oct;27(5):709-20. [2]. Kukovetz WR, et al. Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation. Arzneimittelforschung. 1983;33(10):1450-4. [3]. Rasmussen FV, et al. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. Eur J Respir Dis. 1984 Jan;65(1):20-7. [4]. Selvig K, et al. Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):250-2. Chemical & Physical Properties Molecular Formula C10H14N4O3 Exact Mass 238.10700 PSA 82.05000 Index of Refraction 1.664 InChIKey KYHQZNGJUGFTGR-UHFFFAOYSA-N Storage condition Refrigerator
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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