CAS Number65-28-1
SynonymsEINECS 200-604-6; Phentolamine methanesulfonate salt; 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline Monomethanesulfonate (Salt); 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol methanesulfonate (salt); Phentolamine methanesulfonate; Phentolamine methanesulphonate; Phentolamine mesylate; 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline Monomethanesulfonate (Salt); Methansulfonsäure--3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]benzolol(1:1); 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Monomethanesulfonate (Salt); Phentolamine mesilate; Regitine; 3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol methanesulfonate (1:1); 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol Monomethanesulfonate (Salt)
Molecular FormulaC17H19N3O · CH3SO3H
Molecular Weight377.46
Purity≥98 (TLC)%
Boiling Point551ºC at 760 mmHg
Melting Point180-182 °C (lit.)
Appearancepowder
EINECS200-604-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 65-28-1 |
| Catalog No. | 2A-9011977 |
| Chinese Name | 甲磺酸酚妥拉明 |
| Synonyms | EINECS 200-604-6; Phentolamine methanesulfonate salt; 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline Monomethanesulfonate (Salt); 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol methanesulfonate (salt); Phentolamine methanesulfonate; Phentolamine methanesulphonate; Phentolamine mesylate; 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline Monomethanesulfonate (Salt); Methansulfonsäure--3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]benzolol(1:1); 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Monomethanesulfonate (Salt); Phentolamine mesilate; Regitine; 3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol methanesulfonate (1:1); 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol Monomethanesulfonate (Salt) |
| Molecular Formula | C17H19N3O · CH3SO3H |
| Molecular Weight | 377.46 |
| Purity | ≥98 (TLC) |
| Boiling Point | 551ºC at 760 mmHg |
| Melting Point | 180-182 °C (lit.) |
| Appearance | powder |
| Water Solubility | 50 MG/ML |
| Storage Condition | This product should be kept sealed and dry. |
| Packaging | III |
| Application | Phentolamine mesylate is a competitive, reversible α-adrenergic receptor antagonist with an IC50 between 5 and 30 nM. |
| EINECS | 200-604-6 |
| HTC | 2933290090 |
| PubChem ID | 24277798 |
| MDL Number | MFCD00134201 |
| SMILES | CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3 |
| InChI | 1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4) |
| InChI Key | OGIYDFVHFQEFKQ-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352116 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11977_1_65_28_1.pdf |
| Bioactivity | Phentolamine mesylate is a competitive, reversible α-adrenoceptor antagonist with an IC50 between 5 and 30 nM. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Giussani, D.A., et al., Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero. J Physiol, 1995. 486 ( Pt 1): p. 249-55. [2]. Saeed, M., et al., Alpha-adrenoceptor blockade by phentolamine causes beta-adrenergic vasodilation by increased catecholamine release due to presynaptic alpha-blockade. J Cardiovasc Pharmacol, 1982. 4(1): p. 44-52. Chemical & Physical Properties Boiling Point 551ºC at 760 mmHg Melting Point 180-182 °C(lit.) Molecular Formula C18H23N3O4S Molecular Weight 377.458 Flash Point 287ºC Exact Mass 377.140930 PSA 110.61000 LogP 3.18960 InChIKey OGIYDFVHFQEFKQ-UHFFFAOYSA-N SMILES CS(=O)(=O)O.Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 Storage condition Refrigerator Stability Aq. Solutions Cannot be Stored Water Solubility 50 MG/ML |
| Use of | Phentolamine mesylate is a competitive, reversible α-adrenoceptor antagonist with an IC50 between 5 and 30 nM. Properties Articles36 Name Phentolamine Mesylate Synonym More Synonyms Phentolamine mesilate Biological Activity Description Phentolamine mesylate is a competitive, reversible α-adrenoceptor antagonist with an IC50 between 5 and 30 nM. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Giussani, D.A., et al., Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero. J Physiol, 1995. 486 ( Pt 1): p. 249-55. [2]. Saeed, M., et al., Alpha-adrenoceptor blockade by phentolamine causes beta-adrenergic vasodilation by increased catecholamine release due to presynaptic alpha-blockade. J Cardiovasc Pharmacol, 1982. 4(1): p. 44-52. Chemical & Physical Properties Molecular Formula C18H23N3O4S Exact Mass 377.140930 PSA 110.61000 LogP 3.18960 InChIKey OGIYDFVHFQEFKQ-UHFFFAOYSA-N Storage condition Refrigerator Stability Aq. Solutions Cannot be Stored Water Solubility 50 MG/ML |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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