CAS Number50-60-2
SynonymsFentolamin; EINECS 200-053-1; MFCD00242985; 2-(N-[m-Hydroxyphenyl]-p-toluidinomethyl)imidazoline; Phentalamine; Regitin; Phenotolamine; 3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol; Dibasin; Fentolamina; Regitine; Phentolaminum; Phentolamine; 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol; Rogitine
Molecular FormulaC17H19O1N3
Molecular Weight281.36
Purity98%
Density1.2±0.1 g/cm3
Boiling Point551.0±45.0 °C at 760 mmHg
Melting Point177 - 178ºC
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 50-60-2 |
| Catalog No. | 2A-9011976 |
| Chinese Name | 酚妥拉明 |
| Synonyms | Fentolamin; EINECS 200-053-1; MFCD00242985; 2-(N-[m-Hydroxyphenyl]-p-toluidinomethyl)imidazoline; Phentalamine; Regitin; Phenotolamine; 3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol; Dibasin; Fentolamina; Regitine; Phentolaminum; Phentolamine; 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol; Rogitine |
| Molecular Formula | C17H19O1N3 |
| Molecular Weight | 281.36 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 551.0±45.0 °C at 760 mmHg |
| Melting Point | 177 - 178ºC |
| Appearance | White crystalline powder |
| Storage Condition | -20°C |
| Packaging | II |
| Application | Phentolamine is a potent, selective, and orally active α1-adrenergic and α2-adrenergic receptor antagonist. Phentolamine can be used to treat erectile dysfunction [1][2][3]. |
| HTC | 2933290090 |
| MDL Number | MFCD00242985 |
| SMILES | Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 |
| InChI | InChI=1S/C17H19N3O.ClH/c1-13-2-4-14(5-3-13)20(12-17-18-10-11-19-17)15-6-8-16(21)9-7-15;/h2-9,21H,10-12H2,1H3,(H,18,19);1H |
| InChI Key | MRBDMNSDAVCSSF-UHFFFAOYSA-N |
| Hazard Symbols | 8 |
| MSDS | msds/11976_1_50_60_2.pdf |
| Use of | Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the treatment of erectile dysfunction[1][2][3]. Properties Name phentolamine Synonym More Synonyms Phentolamine Biological Activity Description Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the treatment of erectile dysfunction[1][2][3]. Related Catalog Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor References [1]. Goldstein I I. Oral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction. Int J Impot Res. 2000 Mar;12(S1):S75-S80 [2]. Amabeoku G, et al. Strychnine-induced seizures in mice: the role of noradrenaline. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jul;18(4):753-63. [3]. Fagerholm V, et al. alpha2A-adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice. Br J Pharmacol. 2008 Jul;154(6):1287-96. Chemical & Physical Properties Molecular Formula C17H19N3O Exact Mass 281.152802 PSA 47.86000 Index of Refraction 1.626 InChIKey MRBDMNSDAVCSSF-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphe nyl)amino)- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C17-H19-N3-O MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T5M CN BUTJ B1NR CQ&R D1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 112,319,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - tremor Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1727,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,317,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold REFERENCE : SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 81,352,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 174,243,1968 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7(Suppl 1),72,1984 Safety Information WGK Germany 3 Packaging Group II Hazard Class 8 HS Code 2933290090 Synthetic Route Total: 1 Page 3-[(4-Methylphe... CAS#:61537-49-3 2-(Chloromethyl... CAS#:13338-49-3 Phentolamine CAS#:50-60-2 Literature: CIBA Patent: DE842062 , 1948 ; DRP/DRBP Org.Chem. Full Text Show Details CIBA Patent: US2503059 , 1948 ; Full Text Show Details Urech et al. Helvetica Chimica Acta, 1950 , vol. 33, p. 1386,1403 1,2-Ethanediamine CAS#:107-15-3 Phentolamine CAS#:50-60-2 Literature: CIBA Patent: DE842062 , 1948 ; DRP/DRBP Org.Chem. Full Text Show Details CIBA Patent: US2503059 , 1948 ; Precursor & DownStream Precursor 3 CAS#:61537-49-3 3-[(4-Methylphe... CAS#:13338-49-3 2-(Chloromethyl... CAS#:107-15-3 1,2-Ethanediamine DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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