CAS Number844-26-8
SynonymsSulphene; bithionol sulfoxide; Bithionoloxide; 4,6,4',6'-tetrachloro-2,2'-sulfinyl-di-phenol; Disto-5-cogla; Bitionoloxido [Spanish]; Bithionoloxide [INN]; 2,2'-sulfinyl-bis(4,6-dichlorophenol); Bitin S; Distobitin; Bis-(3,5-dichlor-2-hydroxyphenyl)sulfoxid; Bis-(3.5-dichlor-2-hydroxy-phenyl)-sulfoxyd; Bithionoloxidum [Latin]; 4,6,4',6'-Tetrachlor-2,2'-sulfinyl-di-phenol; Bithionol (sulfoxide)
Molecular FormulaC12H6Cl4O3S
Molecular Weight372.056
Purity98.00%
Density1.86 g/cm3
Boiling Point532.7ºC at 760 mmHg
AppearanceOff-white to pink crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 844-26-8 |
| Catalog No. | 2A-9011978 |
| Chinese Name | 氧硫氯酚 |
| Synonyms | Sulphene; bithionol sulfoxide; Bithionoloxide; 4,6,4',6'-tetrachloro-2,2'-sulfinyl-di-phenol; Disto-5-cogla; Bitionoloxido [Spanish]; Bithionoloxide [INN]; 2,2'-sulfinyl-bis(4,6-dichlorophenol); Bitin S; Distobitin; Bis-(3,5-dichlor-2-hydroxyphenyl)sulfoxid; Bis-(3.5-dichlor-2-hydroxy-phenyl)-sulfoxyd; Bithionoloxidum [Latin]; 4,6,4',6'-Tetrachlor-2,2'-sulfinyl-di-phenol; Bithionol (sulfoxide) |
| Molecular Formula | C12H6Cl4O3S |
| Molecular Weight | 372.056 |
| Purity | 98.00 |
| Density | 1.86 g/cm3 |
| Boiling Point | 532.7ºC at 760 mmHg |
| Appearance | Off-white to pink crystalline powder |
| Storage Condition | 2-8℃ |
| Application | Bithionol sulfoxide (Bitin-S) is an anti-parasitic compound that has been shown to have anti-cancer activity. |
| HTC | 2930909090 |
| MDL Number | MFCD00056677 |
| SMILES | O=S(c1cc(Cl)cc(Cl)c1O)c1cc(Cl)cc(Cl)c1O |
| InChI | InChI=1S/C12H6Cl4O3S/c13-5-1-7(15)11(17)9(3-5)20(19)10-4-6(14)2-8(16)12(10)18/h1-4,17-18H |
| InChI Key | RPAJWWXZIQJVJF-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/11978_1_844_26_8.pdf |
| Bioactivity | Bithionol sulfoxide(Bitin-S) is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Cancer References [1]. Ayyagari VN, et al. Bithionol inhibits ovarian cancer cell growth in vitro - studies on mechanism(s) of action. BMC Cancer. 2014 Feb 4;14:61. [2]. Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62. Chemical & Physical Properties Density 1.86 g/cm3 Boiling Point 532.7ºC at 760 mmHg Molecular Formula C12H6Cl4O3S Molecular Weight 372.05100 Flash Point 276ºC Exact Mass 369.87900 PSA 76.74000 LogP 5.74380 Index of Refraction 1.769 InChIKey RPAJWWXZIQJVJF-UHFFFAOYSA-N SMILES O=S(c1cc(Cl)cc(Cl)c1O)c1cc(Cl)cc(Cl)c1O Storage condition 2-8℃ |
| Use of | Properties Name 2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfinylphenol Synonym More Synonyms Bithionol (sulfoxide) Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Cancer References [1]. Ayyagari VN, et al. Bithionol inhibits ovarian cancer cell growth in vitro - studies on mechanism(s) of action. BMC Cancer. 2014 Feb 4;14:61. [2]. Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62. Chemical & Physical Properties Exact Mass 369.87900 PSA 76.74000 LogP 5.74380 Index of Refraction 1.769 InChIKey RPAJWWXZIQJVJF-UHFFFAOYSA-N Storage condition 2-8℃ |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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