CAS Number50-33-9
Synonyms4-Bromo-N-methylaniline; Kadol; A 7514; Uzone; Azolid; 4-Butyl-1,2-diphenylpyrazolidine-3,5-dione; Phenylbutazone; PBZ; Azdid; 4-Bromo-N-methylbenzenamine; Butoz; EINECS 200-029-0; pyrazinobutazone; Bute; 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione; 1,2-diphenyl-4-butyl-3,5-dioxopyrazolidine; MFCD00005500; Reudo; Buzon
Molecular FormulaC19H20N2O2
Molecular Weight308.37
Purity≥98 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point240.4±23.0 °C at 760 mmHg
Melting Point106-108 °C (lit.)
Appearancepowder
EINECS200-029-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 50-33-9 |
| Catalog No. | 2A-9011980 |
| Chinese Name | 保泰松 |
| Synonyms | 4-Bromo-N-methylaniline; Kadol; A 7514; Uzone; Azolid; 4-Butyl-1,2-diphenylpyrazolidine-3,5-dione; Phenylbutazone; PBZ; Azdid; 4-Bromo-N-methylbenzenamine; Butoz; EINECS 200-029-0; pyrazinobutazone; Bute; 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione; 1,2-diphenyl-4-butyl-3,5-dioxopyrazolidine; MFCD00005500; Reudo; Buzon |
| Molecular Formula | C19H20N2O2 |
| Molecular Weight | 308.37 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 240.4±23.0 °C at 760 mmHg |
| Melting Point | 106-108 °C (lit.) |
| Appearance | powder |
| Water Solubility | <0.1 g/100 mL at 23.5 ºC |
| Storage Condition | This product is sealed and stored in a dry place a |
| Packaging | III |
| Application | Phenylbutazone is a nonsteroidal anti-inflammatory agent. |
| EINECS | 200-029-0 |
| HTC | 2933199090 |
| PubChem ID | 24277729 |
| MDL Number | MFCD00005500 |
| SMILES | CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 |
| InChI | 1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3 |
| InChI Key | VYMDGNCVAMGZFE-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11980_1_50_33_9.pdf |
| Bioactivity | Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.Target: OthersPhenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, when combined with paracetamol and many other household painkillers even in the smallest doses can cause irreversible liver degradation proving fatal in many cases. It is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable.Phenylbutazone may be administered orally (via paste, powder or feed-in) or intravenously. It should not be given intramuscularly or injected in any place other than a vein, as it can cause tissue damage. Tissue damage and edema may also occur if the drug is injected repetitively into the same vein. Phenylbutazone should be administered only under the advice of a veterinarian. Related Catalog Research Areas >> Inflammation/Immunology Target COX-2:1.1 μM (IC50) COX-1:3.7 μM (IC50) References [1]. Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 240.4±23.0 °C at 760 mmHg Melting Point 104-107 °C Molecular Formula C19H20N2O2 Molecular Weight 186.049 Flash Point 99.2±22.6 °C Exact Mass 184.984009 PSA 40.62000 LogP 2.76 Vapour Pressure 0.0±0.5 mmHg at 25°C Index of Refraction 1.613 InChIKey VYMDGNCVAMGZFE-UHFFFAOYSA-N SMILES CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O Stability Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Water Solubility <0.1 g/100 mL at 23.5 ºC |
| Use of | Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.Target: OthersPhenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, when combined with paracetamol and many other household painkillers even in the smallest doses can cause irreversible liver degradation proving fatal in many cases. It is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable.Phenylbutazone may be administered orally (via paste, powder or feed-in) or intravenously. It should not be given intramuscularly or injected in any place other than a vein, as it can cause tissue damage. Tissue damage and edema may also occur if the drug is injected repetitively into the same vein. Phenylbutazone should be administered only under the advice of a veterinarian. Properties Articles86 Name phenylbutazone Synonym More Synonyms Phenylbutazone Biological Activity Description Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.Target: OthersPhenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, when combined with paracetamol and many other household painkillers even in the smallest doses can cause irreversible liver degradation proving fatal in many cases. It is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable.Phenylbutazone may be administered orally (via paste, powder or feed-in) or intravenously. It should not be given intramuscularly or injected in any place other than a vein, as it can cause tissue damage. Tissue damage and edema may also occur if the drug is injected repetitively into the same vein. Phenylbutazone should be administered only under the advice of a veterinarian. Related Catalog Research Areas >> Inflammation/Immunology COX-2:1.1 μM (IC50) COX-1:3.7 μM (IC50) References [1]. Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6. Chemical & Physical Properties Molecular Formula C19H20N2O2 Exact Mass 184.984009 PSA 40.62000 Index of Refraction 1.613 InChIKey VYMDGNCVAMGZFE-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Phenylbutazone) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Phenylbutazone) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Phenylbutazone) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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