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Naphazoline nitrate structure, CAS 5144-52-5

Naphazoline nitrate

CAS Number5144-52-5

Synonyms2-(1-Naphthylmethyl)-2-imidazoline nitrate; 2-(1-Naphthylmethyl)imidazoline nitrate,Naphazolini nitras; naphtyzin; EINECS 225-915-4; 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, nitrate (1:1); MFCD00014316; 2-imidazoline, 2-(1-naphthylmethyl)-, mononitrate; 2-(1-Naphthylmethyl)imidazoline nitrate; NAPHAZOLINI NITRAS; 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole nitrate (1:1); privinenitrate; Privina; Naphazoline nitrate; naphthisen; naftizin; rinazin; 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole nitrate (1:1); naphthizen

Molecular FormulaC14H15N3O3

Molecular Weight273.29

Purity98%

Density

Boiling Point440.5ºC at 760mmHg

Melting Point167-170 °C

Flash Point

Appearancewhite solid

EINECS

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9011575 Purity: 98%
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Quality Control of [ 5144-52-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number5144-52-5
Catalog No.2A-9011575
Chinese Name硝酸萘甲唑啉
Synonyms2-(1-Naphthylmethyl)-2-imidazoline nitrate; 2-(1-Naphthylmethyl)imidazoline nitrate,Naphazolini nitras; naphtyzin; EINECS 225-915-4; 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, nitrate (1:1); MFCD00014316; 2-imidazoline, 2-(1-naphthylmethyl)-, mononitrate; 2-(1-Naphthylmethyl)imidazoline nitrate; NAPHAZOLINI NITRAS; 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole nitrate (1:1); privinenitrate; Privina; Naphazoline nitrate; naphthisen; naftizin; rinazin; 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole nitrate (1:1); naphthizen
Molecular FormulaC14H15N3O3
Molecular Weight273.29
Purity98
Boiling Point440.5ºC at 760mmHg
Melting Point167-170 °C
Appearancewhite solid
Storage ConditionKeep away from light, cool and dry place, sealed a
PackagingIII
ApplicationNaphtazoline (naphtazoline) nitrate is an alpha-adrenergic receptor agonist. Naphtazoline nitrate can reduce vascular permeability and promote vasoconstriction. Naphazoline nitrate can reduce the leve
HTC2933290090
PubChem ID329818399
MDL NumberMFCD00014316
SMILESO[N+]([O-])=O.C1CN=C(Cc2cccc3ccccc23)N1
InChI1S/C14H14N2.HNO3/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;2-1(3)4/h1-7H,8-10H2,(H,15,16);(H,2,3,4)
InChI KeyZAHXYMFVNNUHCP-UHFFFAOYSA-N
Beilstein/REAXYS3779329
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbols6.1(b)
MSDSmsds/11575_1_5144_52_5.pdf
Use ofNaphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline nitrate can be used for non-bacterial conjunctivitis research[1][2]. Properties Name Naphazoline nitrate Synonym More Synonyms Naphazoline nitrate Biological Activity Description Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline nitrate can be used for non-bacterial conjunctivitis research[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR References [1]. Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13(4):3319-25. [2]. Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203(1):125-31. Chemical & Physical Properties Molecular Formula C14H15N3O3 Exact Mass 273.111328 PSA 90.44000 LogP 2.32390 InChIKey ZAHXYMFVNNUHCP-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2-Imidazoline, 2-(1-naphthylmethyl)-, mononitrate CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C14-H14-N2.H-N-O3 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L66J B1- BT5M CN BUTJ &..H..N-O3 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 21,204,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,539,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 21,204,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 21,204,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,539,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 13200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 21,204,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,539,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,539,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,539,1982 Safety Information Signal Word Warning Hazard Statements H302 Precautionary Statements P301 + P312 + P330 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn:Harmful; Risk Phrases R22 RIDADR 3249 WGK Germany 3 RTECS NJ4376000 Packaging Group III Hazard Class 6.1(b) HS Code 2933290090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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