CAS Number105816-04-4
SynonymsGlinate; Starsis; SDZ DJN 608; Starlix; (2R)-2-{[(trans-4-Isopropylcyclohexyl)carbonyl]amino}-3-phenylpropanoic acid; N-{[trans-4-(1-methylethyl)cyclohexyl]carbonyl}-D-phenylalanine; (-)-N-(trans-4-Isopropylcyclohexanecarbonyl)-D-phenylalanine; (2R)-2-({[trans-4-(1-methylethyl)cyclohexyl]carbonyl}amino)-3-phenylpropanoic acid; DJN 608; Natelide; N-[[trans-4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanine; N-{[trans-4-(Propan-2-yl)cyclohexyl]carbonyl}-D-phenylalanin; MFCD00875706; ay4166; Starlix DS; Fastic-d5; A-4166; Fastic; N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine; (-)-N-(trans-4-Isopropylcyclohexyl-1-carbonyl)-D-phenylalanine; Nateglinide
Molecular FormulaC19H27NO3
Molecular Weight317.42
Purity≥98 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point527.6±39.0 °C at 760 mmHg
Melting Point137-141ºC
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 105816-04-4 |
| Catalog No. | 2A-9011587 |
| Chinese Name | 那格列奈 |
| Synonyms | Glinate; Starsis; SDZ DJN 608; Starlix; (2R)-2-{[(trans-4-Isopropylcyclohexyl)carbonyl]amino}-3-phenylpropanoic acid; N-{[trans-4-(1-methylethyl)cyclohexyl]carbonyl}-D-phenylalanine; (-)-N-(trans-4-Isopropylcyclohexanecarbonyl)-D-phenylalanine; (2R)-2-({[trans-4-(1-methylethyl)cyclohexyl]carbonyl}amino)-3-phenylpropanoic acid; DJN 608; Natelide; N-[[trans-4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanine; N-{[trans-4-(Propan-2-yl)cyclohexyl]carbonyl}-D-phenylalanin; MFCD00875706; ay4166; Starlix DS; Fastic-d5; A-4166; Fastic; N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine; (-)-N-(trans-4-Isopropylcyclohexyl-1-carbonyl)-D-phenylalanine; Nateglinide |
| Molecular Formula | C19H27NO3 |
| Molecular Weight | 317.42 |
| Purity | ≥98 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 527.6±39.0 °C at 760 mmHg |
| Melting Point | 137-141ºC |
| Appearance | solid |
| Storage Condition | Room temp |
| Application | Nateglinide is an insulin secretagogue that can act on non-insulin-dependent diabetes mellitus (NIDDM). |
| HTC | 2924299090 |
| PubChem ID | 329818636 |
| MDL Number | MFCD00875706 |
| SMILES | CC(C)[C@@H]1CC[C@H](CC1)C(=O)N[C@H](Cc2ccccc2)C(O)=O |
| InChI | 1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1 |
| InChI Key | OELFLUMRDSZNSF-BRWVUGGUSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/11587_1_105816_04_4.pdf |
| Bioactivity | Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).Target: OthersNateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those na?ve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Nateglinide is extensively metabolized in the liver and excreted in urine (83%) and feces (10%). The major metabolites possess less activity than the parent compound. One minor metabolite, the isoprene, has the same potency as its parent compound [1-3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease References [1]. http://205.193.93.51/dpdonline/searchRequest.dodin=2245439 [2]. http://www.drugs.com/cdi/nateglinide.html [3]. http://www.drugbank.ca/drugs/DB00731 Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 527.6±39.0 °C at 760 mmHg Melting Point 137-141ºC Molecular Formula C19H27NO3 Molecular Weight 317.423 Flash Point 272.9±27.1 °C Exact Mass 317.199097 PSA 66.40000 LogP 4.21 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.536 Storage condition Room temp |
| Use of | Properties Articles50 Name nateglinide Synonym More Synonyms Nateglinide Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease References [2]. http://www.drugs.com/cdi/nateglinide.html [3]. http://www.drugbank.ca/drugs/DB00731 Chemical & Physical Properties Molecular Formula C19H27NO3 Exact Mass 317.199097 PSA 66.40000 Index of Refraction 1.536 Storage condition Room temp |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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