CAS Number835-31-4
Synonymsnaphazoline; Sanorin; Clearine; Naphthizine; 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole; Clera; EINECS 212-641-5; MFCD00012554; Naphcon; Coldan; Antan; Nafazolina
Molecular FormulaC14H14N2
Molecular Weight210.28
Purity98%
Density1.2±0.1 g/cm3
Boiling Point440.5±24.0 °C at 760 mmHg
Melting Point254ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 835-31-4 |
| Catalog No. | 2A-9011573 |
| Chinese Name | 萘甲唑啉 |
| Synonyms | naphazoline; Sanorin; Clearine; Naphthizine; 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole; Clera; EINECS 212-641-5; MFCD00012554; Naphcon; Coldan; Antan; Nafazolina |
| Molecular Formula | C14H14N2 |
| Molecular Weight | 210.28 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 440.5±24.0 °C at 760 mmHg |
| Melting Point | 254ºC |
| Storage Condition | 2-8°C |
| Application | Naphazoline (naphtazoline) is a potent alpha-adrenoceptor agonist. Naphazoline can reduce vascular permeability and promote vasoconstriction. Naphazoline can reduce the levels of inflammatory factors |
| HTC | 2934999090 |
| MDL Number | C14H14N2 |
| SMILES | c1ccc2c(CC3=NCCN3)cccc2c1 |
| InChI | InChI=1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H |
| InChI Key | CNIIGCLFLJGOGP-UHFFFAOYSA-N |
| MSDS | msds/11573_1_835_31_4.pdf |
| Use of | Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline can be used for non-bacterial conjunctivitis research[1][2]. Properties Name 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole Synonym More Synonyms naphazoline Biological Activity Description Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline can be used for non-bacterial conjunctivitis research[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR References [1]. Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13(4):3319-25. [2]. Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203(1):125-31. Chemical & Physical Properties Molecular Formula C14H14N2 Exact Mass 210.115692 PSA 24.39000 Index of Refraction 1.640 InChIKey CNIIGCLFLJGOGP-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2-Imidazoline, 2-(1-naphthylmethyl)- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C14-H14-N2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L66J B1- BT5M CN BUTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 9,280,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,729,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,729,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 37,198,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 9,280,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 9,280,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 9,280,1950 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 192,141,1939 Safety Information Hazard Codes T: Toxic; Risk Phrases R25 Safety Phrases 45 WGK Germany 3 RTECS NJ4375000 HS Code 2934999090 Synthetic Route 1-Naphthaleneac... CAS#:86-87-3 Ethylenediamine... CAS#:6780-13-8 naphazoline CAS#:835-31-4 1-Naphthylaceto... CAS#:132-75-2 2-Aminoethanol CAS#:141-43-5 naphazoline CAS#:835-31-4 Literature: Monatshefte fuer Chemie, , vol. 80, p. 815,818 4-methylbenzene... CAS#:68211-49-4 naphazoline CAS#:835-31-4 Literature: US2813862 , ; Precursor & DownStream Precursor 7 CAS#:86-87-3 1-Naphthaleneac... CAS#:6780-13-8 Ethylenediamine... CAS#:132-75-2 1-Naphthylaceto... CAS#:141-43-5 2-Aminoethanol DownStream 2 CAS#:1019-21-2 2-(naphthalen-1... CAS#:36321-43-4 N-(2-Aminoethyl... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Nalbuphine | 20594-83-6 | 2A-9011563 |
| Nalidixic acid | 389-08-2 | 2A-9011564 |
| Nalmefene hydrochloride | 58895-64-0 | 2A-9011565 |
| Namirotene | 101506-83-6 | 2A-9011568 |
| Nandrolon | 434-22-0 | 2A-9011569 |
| Naphazoline hydrochloride | 550-99-2 | 2A-9011574 |
| Naphazoline nitrate | 5144-52-5 | 2A-9011575 |
| Napropamide | 15299-99-7 | 2A-9011576 |
| Naroparcil | 120819-70-7 | 2A-9011584 |
| Natamycin | 7681-93-8 | 2A-0201795 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS