CAS Number389-08-2
Synonymsuriben; EINECS 206-864-7; uroman; uropan; NegGram; NOGRAM; WIN-18320; nalidixic acid; Urisal; nalix; 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; Ethyl-7-methyl-1,8-naphthyridin-4-one-3-carboxylic Acid; 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic Acid; T66 BV EN GNJ CVQ E2 H1; poleon; negram; WINTOMYLON; cybis; uroneg; MFCD00006884
Molecular FormulaC12H12N2O3
Molecular Weight232.24
Purity≥98%
Density1.3±0.1 g/cm3
Boiling Point413.1±45.0 °C at 760 mmHg
Melting Point227-229 °C (lit.)
Appearancepowder
EINECS206-864-7
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 389-08-2 |
| Catalog No. | 2A-9011564 |
| Chinese Name | 萘啶酮酸 |
| Synonyms | uriben; EINECS 206-864-7; uroman; uropan; NegGram; NOGRAM; WIN-18320; nalidixic acid; Urisal; nalix; 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; Ethyl-7-methyl-1,8-naphthyridin-4-one-3-carboxylic Acid; 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic Acid; T66 BV EN GNJ CVQ E2 H1; poleon; negram; WINTOMYLON; cybis; uroneg; MFCD00006884 |
| Molecular Formula | C12H12N2O3 |
| Molecular Weight | 232.24 |
| Purity | ≥98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 413.1±45.0 °C at 760 mmHg |
| Melting Point | 227-229 °C (lit.) |
| Appearance | powder |
| Water Solubility | 0.1 G/L (23 ºC) |
| Storage Condition | Keep sealed. |
| Application | Nalidixic acid has a limited bactericidal spectrum. |
| EINECS | 206-864-7 |
| HTC | 2933990090 |
| PubChem ID | 24897864 |
| MDL Number | MFCD00006884 |
| SMILES | CCN1C=C(C(O)=O)C(=O)c2ccc(C)nc12 |
| InChI | 1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17) |
| InChI Key | MHWLWQUZZRMNGJ-UHFFFAOYSA-N |
| Beilstein/REAXYS | 750515 |
| NACRES Code | NA.77 |
| UNSPSC | 12352106 |
| MSDS | msds/11564_1_389_08_2.pdf |
| Bioactivity | Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum.Target: AntibacterialNalidixic acid is the first of the synthetic quinolone antibiotics. Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth. Nalidixic selectively and reversibly blocks DNA replication in susceptible bacteria. Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and topoisomerase IV and induce formation of cleavage complexes. It also inhibits the nicking-closing activity on the subunit of DNA gyrase that releases the positive binding stress on the supercoiled DNA. From Wikipedia. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. http://en.wikipedia.org/wiki/Nalidixic_acid Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 413.1±45.0 °C at 760 mmHg Melting Point 227-229 °C(lit.) Molecular Formula C12H12N2O3 Molecular Weight 232.235 Flash Point 203.6±28.7 °C Exact Mass 232.084793 PSA 72.19000 LogP 1.19 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.605 InChIKey MHWLWQUZZRMNGJ-UHFFFAOYSA-N SMILES CCn1cc(C(=O)O)c(=O)c2ccc(C)nc21 Storage condition 0-6°C Stability Stable. Incompatible with strong oxidizing agents. Water Solubility 0.1 G/L (23 ºC) |
| Use of | Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum.Target: AntibacterialNalidixic acid is the first of the synthetic quinolone antibiotics. Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth. Nalidixic selectively and reversibly blocks DNA replication in susceptible bacteria. Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and topoisomerase IV and induce formation of cleavage complexes. It also inhibits the nicking-closing activity on the subunit of DNA gyrase that releases the positive binding stress on the supercoiled DNA. From Wikipedia. Properties Articles244 Name nalidixic acid Synonym More Synonyms Nalidixic acid Biological Activity Description Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum.Target: AntibacterialNalidixic acid is the first of the synthetic quinolone antibiotics. Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth. Nalidixic selectively and reversibly blocks DNA replication in susceptible bacteria. Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and topoisomerase IV and induce formation of cleavage complexes. It also inhibits the nicking-closing activity on the subunit of DNA gyrase that releases the positive binding stress on the supercoiled DNA. From Wikipedia. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. http://en.wikipedia.org/wiki/Nalidixic_acid Chemical & Physical Properties Molecular Formula C12H12N2O3 Exact Mass 232.084793 PSA 72.19000 Index of Refraction 1.605 InChIKey MHWLWQUZZRMNGJ-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents. Water Solubility 0.1 G/L (23 ºC) |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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