CAS Number3200-06-4
SynonymsNafronyl oxalate salt; diethyl{2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl}ammonium hydrogen oxalate; Praxilene; EINECS 221-703-0; Dubimax; Iridus; nafronyl acid oxalate; Dusodril; naftidrofuryl oxalate; MFCD00079473; 2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate oxalate; LS-121; nafronyl oxalate; Naftidrofuryl (oxalate)
Molecular FormulaC26H35NO7
Molecular Weight473.56
Purity99.00%
Density1.2205 (rough estimate)
Boiling Point574°C (rough estimate)
Melting Point110-111°
Appearancepowder
EINECS221-703-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3200-06-4 |
| Catalog No. | 2A-9011558 |
| Chinese Name | 萘呋胺酯 草酸盐 |
| Synonyms | Nafronyl oxalate salt; diethyl{2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl}ammonium hydrogen oxalate; Praxilene; EINECS 221-703-0; Dubimax; Iridus; nafronyl acid oxalate; Dusodril; naftidrofuryl oxalate; MFCD00079473; 2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate oxalate; LS-121; nafronyl oxalate; Naftidrofuryl (oxalate) |
| Molecular Formula | C26H35NO7 |
| Molecular Weight | 473.56 |
| Purity | 99.00 |
| Density | 1.2205 (rough estimate) |
| Boiling Point | 574°C (rough estimate) |
| Melting Point | 110-111° |
| Appearance | powder |
| Water Solubility | Freely soluble in water, freely soluble or soluble |
| Storage Condition | Sealed in a cool, dry environment |
| Application | Naftidrofuryl is a drug used in the management of peripheral blood and cerebrovascular disorders as a vasodilator, increases cellular oxidative capacity, and is a 5-HT2 receptor antagonist. |
| EINECS | 221-703-0 |
| HTC | 29321900 |
| PubChem ID | 329818576 |
| MDL Number | MFCD00079473 |
| SMILES | OC(=O)C(O)=O.CCN(CC)CCOC(=O)C(CC1CCCO1)Cc2cccc3ccccc23 |
| InChI | 1S/C24H33NO3.C2H2O4/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20;3-1(4)2(5)6/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3;(H,3,4)(H,5,6) |
| InChI Key | SSAJNPNVUYMUCI-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/11558_1_3200_06_4.pdf |
| Bioactivity | Naftidrofuryl is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.Target: 5-HT2 receptorNaftidrofuryl may be effective for relieving the pain of muscle cramps.[1]Naftidrofuryl oxalate is the only vasoactive drug for peripheral arterial disease (PAD) which is likely to be cost-effective.[2]Naftidrofuryl oxalate is ranked first for both maximum walking distance (MWD) and pain-free walking distance (PFWD) (probability of 0·947 and 0·987, respectively, of being the best treatment) followed by cilostazol and pentoxifylline. Naftidrofuryl oxalate is effective treatments for claudication, Naftidrofuryl oxalate is likely to be the most effective, with minimal serious adverse events.[3] Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Cardiovascular Disease References [1]. Naftidrofuryl [2]. Meng Y, et al. Cost-effectiveness of cilostazol, naftidrofuryl oxalate, and pentoxifylline for the treatment of intermittent claudication in people with peripheral arterial disease. Angiology. 2014 Mar;65(3):190-197. [3]. Stevens JW, et al. Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication. Br J Surg. 2012 Dec;99(12):1630-1638. Chemical & Physical Properties Density 1.2205 (rough estimate) Boiling Point 574°C (rough estimate) Melting Point 110-111° Molecular Formula C26H35NO7 Molecular Weight 473.55900 Exact Mass 473.24100 PSA 113.37000 LogP 3.60820 Index of Refraction 1.6000 (estimate) InChIKey SSAJNPNVUYMUCI-UHFFFAOYSA-N SMILES CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1.O=C(O)C(=O)O Storage condition -20℃ Water Solubility Freely soluble in water, freely soluble or soluble in ethanol (96 per cent), slightly or sparingly soluble in acetone. |
| Use of | Naftidrofuryl is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.Target: 5-HT2 receptorNaftidrofuryl may be effective for relieving the pain of muscle cramps.[1]Naftidrofuryl oxalate is the only vasoactive drug for peripheral arterial disease (PAD) which is likely to be cost-effective.[2]Naftidrofuryl oxalate is ranked first for both maximum walking distance (MWD) and pain-free walking distance (PFWD) (probability of 0·947 and 0·987, respectively, of being the best treatment) followed by cilostazol and pentoxifylline. Naftidrofuryl oxalate is effective treatments for claudication, Naftidrofuryl oxalate is likely to be the most effective, with minimal serious adverse events.[3] Properties Name 2-(diethylamino)ethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate,oxalic acid Synonym More Synonyms Naftidrofuryl (oxalate) Biological Activity Description Naftidrofuryl is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.Target: 5-HT2 receptorNaftidrofuryl may be effective for relieving the pain of muscle cramps.[1]Naftidrofuryl oxalate is the only vasoactive drug for peripheral arterial disease (PAD) which is likely to be cost-effective.[2]Naftidrofuryl oxalate is ranked first for both maximum walking distance (MWD) and pain-free walking distance (PFWD) (probability of 0·947 and 0·987, respectively, of being the best treatment) followed by cilostazol and pentoxifylline. Naftidrofuryl oxalate is effective treatments for claudication, Naftidrofuryl oxalate is likely to be the most effective, with minimal serious adverse events.[3] Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Cardiovascular Disease References [1]. Naftidrofuryl [2]. Meng Y, et al. Cost-effectiveness of cilostazol, naftidrofuryl oxalate, and pentoxifylline for the treatment of intermittent claudication in people with peripheral arterial disease. Angiology. 2014 Mar;65(3):190-197. [3]. Stevens JW, et al. Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication. Br J Surg. 2012 Dec;99(12):1630-1638. Chemical & Physical Properties Molecular Formula C26H35NO7 Exact Mass 473.24100 PSA 113.37000 LogP 3.60820 Index of Refraction 1.6000 (estimate) InChIKey SSAJNPNVUYMUCI-UHFFFAOYSA-N Storage condition -20℃ Water Solubility Freely soluble in water, freely soluble or soluble in ethanol (96 per cent), slightly or sparingly soluble in acetone. |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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