CAS Number38304-91-5
SynonymsRegaine; EINECS 253-874-2; 2,4-diamino-6-piperidino-pyrimidine-3-oxide; 2,6-Diamino-4-piperidinopyrimidine 1-Oxide; Rogaine; MFCD00063409; Theroxidil; 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine; Tricoxidil; 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide; Lonolox; (2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol; 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide (6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide; 2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxide; Alostil; Loniten; Minoximen
Molecular FormulaC9H15N5O
Molecular Weight209.25
Purity≥99 (TLC)%
Density1.5±0.1 g/cm3
Boiling Point351.7±45.0 °C at 760 mmHg
Melting Point272-274 °C (dec.) (lit.)
AppearanceWhite crystalline powder
EINECS253-874-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 38304-91-5 |
| Catalog No. | 2A-9011459 |
| Chinese Name | 米诺地尔 |
| Synonyms | Regaine; EINECS 253-874-2; 2,4-diamino-6-piperidino-pyrimidine-3-oxide; 2,6-Diamino-4-piperidinopyrimidine 1-Oxide; Rogaine; MFCD00063409; Theroxidil; 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine; Tricoxidil; 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide; Lonolox; (2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol; 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide (6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide; 2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxide; Alostil; Loniten; Minoximen |
| Molecular Formula | C9H15N5O |
| Molecular Weight | 209.25 |
| Purity | ≥99 (TLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 351.7±45.0 °C at 760 mmHg |
| Melting Point | 272-274 °C (dec.) (lit.) |
| Appearance | White crystalline powder |
| Storage Condition | Sealed, cool, dry storage |
| Application | Minoxidil (U 10858) is a vasodilator that can be used to treat high blood pressure and hair loss. |
| EINECS | 253-874-2 |
| HTC | 2933990090 |
| PubChem ID | 24277853 |
| MDL Number | MFCD00063409 |
| SMILES | NC1=CC(=NC(=N)N1O)N2CCCCC2 |
| InChI | 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2 |
| InChI Key | ZIMGGGWCDYVHOY-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/11459_1_38304_91_5.pdf |
| Bioactivity | Minoxidil(U 10858) is an antihypertensive vasodilator medication. Target: potassium channel Minoxidil, a potent antihypertensive agent, induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. The pharmacologic mechanisms by which minoxidil stimulates hair growth are unknown. This study was designed to examine whether minoxidil has direct effects on neonatal murine epidermal cells in culture. In the presence of minoxidil, cultures showed a marked dose-dependent second peak of DNA synthesis 8-10 days after culture initiation. In addition, two morphologically distinct cell types appeared. Indirect immunofluorescence staining with keratin-specific antibody revealed cytoplasmic keratin fibers, suggesting the epidermal origin of these cells. Our experiments demonstrate that minoxidil can affect epidermal cells in culture by altering their growth pattern and phenotypic appearance [1] . Finite doses of minoxidil (2%, w/v) in formulations containing varying amounts of ethanol, propylene glycol (PG), and water (60:20:20, 80:20:0, and 0:80:20 by volume, respectively) were used. Minoxidil in SC (by tape stripping), appendages (by cyanoacrylate casting), and receptor fluid was determined by liquid scintillation counting. At early times (30 min, 2 h), ethanol-containing formulations (60:20:20 and 80:20:0) caused significantly greater minoxidil retention in SC and appendages, compared to the formulation lacking ethanol (0:80:20). A significant increase in minoxidil receptor penetration occurred with the PG-rich 0:80:20 formulation after 12 h [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease References [1]. Cohen, R.L., et al., Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol, 1984. 82(1): p. 90-3. [2]. Grice, J.E., et al., Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. J Pharm Sci, 2010. 99(2): p. 712-8. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 351.7±45.0 °C at 760 mmHg Melting Point 272-274 °C (dec.)(lit.) Molecular Formula C9H15N5O Molecular Weight 209.248 Flash Point 166.5±28.7 °C Exact Mass 209.127655 PSA 91.16000 LogP -1.49 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.724 InChIKey ZIMGGGWCDYVHOY-UHFFFAOYSA-N SMILES N=c1nc(N2CCCCC2)cc(N)n1O Storage condition Store at RT |
| Use of | Properties Articles59 Name minoxidil Synonym More Synonyms Minoxidil Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease References [1]. Cohen, R.L., et al., Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol, 1984. 82(1): p. 90-3. [2]. Grice, J.E., et al., Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. J Pharm Sci, 2010. 99(2): p. 712-8. Chemical & Physical Properties Molecular Formula C9H15N5O Exact Mass 209.127655 PSA 91.16000 LogP -1.49 Index of Refraction 1.724 InChIKey ZIMGGGWCDYVHOY-UHFFFAOYSA-N Storage condition Store at RT |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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