| Chemical & Physical Properties | |
|---|---|
| CAS Number | 129688-50-2 |
| Catalog No. | 2A-9011454 |
| Chinese Name | 米那司他 |
| Synonyms | Minalrestat (USAN/INN); Minalrestat; WAY-ARI-509; Bffipt |
| Molecular Formula | C19H11BrF2N2O4 |
| Molecular Weight | 449.21 |
| Purity | 98.00 |
| Density | 1.79g/cm3 |
| Boiling Point | 707.4ºC at 760mmHg |
| Application | Minasstat (ARI-509) is a potent orally active aldose reductase inhibitor. Minasstat can be used in diabetes research [1]. |
| HTC | 2933990090 |
| MDL Number | C19H11BrF2N2O4 |
| SMILES | O=C1CC2(C(=O)N1)C(=O)N(Cc1ccc(Br)cc1F)C(=O)c1ccc(F)cc12 |
| InChI | InChI=1S/C19H11BrF2N2O4/c20-10-2-1-9(14(22)5-10)8-24-16(26)12-4-3-11(21)6-13(12)19(18(24)28)7-15(25)23-17(19)27/h1-6H,7-8H2,(H,23,25,27) |
| InChI Key | BMHZAHGTGIZZCT-UHFFFAOYSA-N |
| MSDS | msds/11454_1_129688_50_2.pdf |
| Use of | Minalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes[1]. Properties Name 2-[(4-bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'-tetrone Synonym More Synonyms Minalrestat Biological Activity Description Minalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes[1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase Research Areas >> Metabolic Disease In Vitro Minalrestat (100 μM) Reduces sorbitol content in primary cultured rat cells without affecting intracellular glucose content [3]. Minalrestat (100 μM, 48 h) causes the accumulation of PKC-α and -β2 in primary cultured rat mesangial cells [3]. Western Blot Analysis[3] Cell Line: Primary cultured rat mesangial cells Concentration: 100 μM Incubation Time: 48 h Result: Increased accumulation of PKC-α and -β2. References [1]. Akamine EH, et al. Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes. J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42. [2]. Cruz JW, et al. Minalrestat and leukocyte migration in diabetes mellitus. Diabetes Metab Res Rev. 2003 May-Jun;19(3):223-31. [3]. Kapor-Drezgic J, et al. Effect of high glucose on mesangial cell protein kinase C-delta and -epsilon is polyol pathway-dependent. J Am Soc Nephrol. 1999 Jun;10(6):1193-203. Chemical & Physical Properties Molecular Formula C19H11BrF2N2O4 Exact Mass 447.98700 PSA 83.55000 LogP 2.46090 Index of Refraction 1.689 InChIKey BMHZAHGTGIZZCT-UHFFFAOYSA-N Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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