CAS Number3685-84-5
SynonymsAcetic acid, (p-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride; EINECS 222-975-3; Acetic acid, (4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride; 2-(Dimethylamino)ethyl (p-chlorophenoxy)acetate hydrochloride; MFCD00012533; Clocete; Acetic acid, (p-chlorophenoxy)-, 2-(dimethylamino)ethyl ester hydrochloride; Centrophenoxine hydrochloride; 2-(dimethylamino)ethyl 2-(4-chlorophenoxy)acetate,hydrochloride; 2-(Dimethylamino)ethyl 4-Chlorophenoxyacetate Hydrochloride; 2-(Dimethylamino)ethyl (4-chlorophenoxy)acetate hydrochloride (1:1); Meclofenoxate Hydrochloride; Acetic acid, 2-(4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride (1:1); Meclofenoxate (hydrochloride)
Molecular FormulaC12H17Cl2NO3
Molecular Weight294.174
Purity98%
Boiling Point345.9ºC at 760mmHg
Melting Point133-135°C
AppearanceWhite to off-white solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3685-84-5 |
| Catalog No. | 2A-9011306 |
| Chinese Name | 盐酸甲氯芬酯 |
| Synonyms | Acetic acid, (p-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride; EINECS 222-975-3; Acetic acid, (4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride; 2-(Dimethylamino)ethyl (p-chlorophenoxy)acetate hydrochloride; MFCD00012533; Clocete; Acetic acid, (p-chlorophenoxy)-, 2-(dimethylamino)ethyl ester hydrochloride; Centrophenoxine hydrochloride; 2-(dimethylamino)ethyl 2-(4-chlorophenoxy)acetate,hydrochloride; 2-(Dimethylamino)ethyl 4-Chlorophenoxyacetate Hydrochloride; 2-(Dimethylamino)ethyl (4-chlorophenoxy)acetate hydrochloride (1:1); Meclofenoxate Hydrochloride; Acetic acid, 2-(4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride (1:1); Meclofenoxate (hydrochloride) |
| Molecular Formula | C12H17Cl2NO3 |
| Molecular Weight | 294.174 |
| Purity | 98 |
| Boiling Point | 345.9ºC at 760mmHg |
| Melting Point | 133-135°C |
| Appearance | White to off-white solid |
| Storage Condition | The warehouse is ventilated and dried at low tempe |
| Application | Meclofenoxate hydrochloride is an ester synthesized from DMAE and pCPA, which has the activity of stimulating memory and improving cognition. |
| HTC | 2922509090 |
| SMILES | CN(C)CCOC(=O)COc1ccc(Cl)cc1.Cl |
| InChI | InChI=1S/C12H16ClNO3.ClH/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11;/h3-6H,7-9H2,1-2H3;1H |
| InChI Key | FIVHOHCAXWQPGC-UHFFFAOYSA-N |
| Bioactivity | Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.IC50 value: Target: nootropicMeclofenoxate, administered in a dose of 50 mg/kg twice daily for 7 days using the maze-training method, increased the number of responses to the conditioned stimulus, when retention tests were made 24 hours and 7 days after training, whereas citicholine, applied in the same way in a dose of 10 mg/kg, shortened the latency of the responses with reinforcement during the training and increased the number of correct responses to the conditioned stimulus in retention tests 7 days after the training [1]. Meclofenoxate appears to increase the consolidation of new information into long-term memory, but does not affect other aspects of remembering [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease References [1]. Mosharrof AH, et al. Effects of meclofenoxate and citicholine on learning and memory in aged rats. Acta Physiol Pharmacol Bulg. 1987;13(4):17-24. [2]. Marcer D, et al. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977 May;6(2):123-31. Chemical & Physical Properties Boiling Point 345.9ºC at 760mmHg Melting Point 133-135°C Molecular Formula C12H17Cl2NO3 Molecular Weight 294.174 Exact Mass 293.058563 PSA 38.77000 LogP 2.62560 InChIKey FIVHOHCAXWQPGC-UHFFFAOYSA-N SMILES CN(C)CCOC(=O)COc1ccc(Cl)cc1.Cl Storage condition −20°C |
| Use of | Properties Name Meclofenoxate Hydrochloride Synonym More Synonyms Centrophenoxine hydrochloride Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease References [1]. Mosharrof AH, et al. Effects of meclofenoxate and citicholine on learning and memory in aged rats. Acta Physiol Pharmacol Bulg. 1987;13(4):17-24. [2]. Marcer D, et al. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977 May;6(2):123-31. Chemical & Physical Properties Exact Mass 293.058563 PSA 38.77000 LogP 2.62560 InChIKey FIVHOHCAXWQPGC-UHFFFAOYSA-N |
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