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Meclofenamate sodium structure, CAS 6385-02-0

Meclofenamate sodium

CAS Number6385-02-0

SynonymsSodium 2-[(2,6-dichloro-3-methylphenyl)amino]benzoate hydrate (1:1:1); sodium,2-(2,6-dichloro-3-methylanilino)benzoate; Monosodium N-(2,6-dichloro-m-tolyl)anthranilate monohydrate; EINECS 228-983-3; Sodium meclophenamate; MFCD00077376; 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic Acid Monosodium Salt Monohydrate; Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt, hydrate (1:1:1); Sodium meclofenamate; N-(2,6-Dichloro-m-tolyl)anthranilic Acid Monosodium Salt Monohydrate; Movens

Molecular FormulaC14H10Cl2NO2Na

Molecular Weight318.13

Purity≥93 (HPLC)%

Density

Boiling Point399.4ºC at 760 mmHg

Melting Point287 °C

Flash Point

Appearancepowder

EINECS228-983-3

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9011305 Purity: ≥93 (HPLC)%
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Quality Control of [ 6385-02-0 ] Purity: ≥93 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number6385-02-0
Catalog No.2A-9011305
Chinese Name甲氯芬那酸钠
SynonymsSodium 2-[(2,6-dichloro-3-methylphenyl)amino]benzoate hydrate (1:1:1); sodium,2-(2,6-dichloro-3-methylanilino)benzoate; Monosodium N-(2,6-dichloro-m-tolyl)anthranilate monohydrate; EINECS 228-983-3; Sodium meclophenamate; MFCD00077376; 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic Acid Monosodium Salt Monohydrate; Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt, hydrate (1:1:1); Sodium meclofenamate; N-(2,6-Dichloro-m-tolyl)anthranilic Acid Monosodium Salt Monohydrate; Movens
Molecular FormulaC14H10Cl2NO2Na
Molecular Weight318.13
Purity≥93 (HPLC)
Boiling Point399.4ºC at 760 mmHg
Melting Point287 °C
Appearancepowder
Water SolubilitySoluble in water at 50mg/ml. Also soluble in DMF,
Storage ConditionStore in inert gas; avoid moisture (moisture absor
ApplicationMeclofenamic acid sodium (Meclofenamic acid sodium) is a nonsteroidal anti-inflammatory drug (NSAID) approved for arthritis (osteoarthritis and rheumatoid arthritis), analgesia (mild to moderate pain)
EINECS228-983-3
HTC2922499990
PubChem ID24278553
MDL NumberMFCD00077376
SMILES[Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
InChI1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;
InChI KeyCHGIZYUDGOIAFY-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352106
Hazard SymbolsTransport
MSDSmsds/11305_1_6385_02_0.pdf
BioactivityMeclofenamic acid sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3]. References [1]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8. [2]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017. [3]. Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84. Chemical & Physical Properties Boiling Point 399.4ºC at 760 mmHg Melting Point 287 °C Molecular Formula C14H10Cl2NNaO2 Molecular Weight 336.146 Flash Point 195.3ºC Exact Mass 335.009186 PSA 52.16000 LogP 3.48190 InChIKey OGPIIGMUPMPMNT-UHFFFAOYSA-M SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)[O-])c1Cl.[Na+] Water Solubility Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
Use ofMeclofenamic acid sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3]. Properties Name meclofenamate sodium Synonym More Synonyms Movens Biological Activity Description Meclofenamic acid sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3]. References [1]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8. [2]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017. [3]. Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84. Chemical & Physical Properties Exact Mass 335.009186 PSA 52.16000 LogP 3.48190 InChIKey OGPIIGMUPMPMNT-UHFFFAOYSA-M
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Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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