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Meclizine hydrochloride structure, CAS 1104-22-9

Meclizine hydrochloride

CAS Number1104-22-9

SynonymsPiperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, hydrochloride (1:2); Piperazine, 1- (p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride; EINECS 214-164-8; Meclizine diHCl; UNII:L997QXC9J1; ancolandihydrochloride; Meclizine (dihydrochloride); 1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride; Meclozine Hcl; UNII:408UZ554UD; diadril; Meclozine dihydrochloride; UNII:V5604WJ3XP; mecilizine hydrochloride; bonamine; MFCD00058199; 1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine dihydrochloride; Navidoxine; Meclizine 2HCl

Molecular FormulaC25H29Cl3N2

Molecular Weight463.87

Purity98%

Density1.159g/cm3

Boiling Point495.3ºC at 760mmHg

Melting Point212 °C

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9011304 Purity: 98%
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Quality Control of [ 1104-22-9 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1104-22-9
Catalog No.2A-9011304
Chinese Name盐酸美克洛嗪
SynonymsPiperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, hydrochloride (1:2); Piperazine, 1- (p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride; EINECS 214-164-8; Meclizine diHCl; UNII:L997QXC9J1; ancolandihydrochloride; Meclizine (dihydrochloride); 1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride; Meclozine Hcl; UNII:408UZ554UD; diadril; Meclozine dihydrochloride; UNII:V5604WJ3XP; mecilizine hydrochloride; bonamine; MFCD00058199; 1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine dihydrochloride; Navidoxine; Meclizine 2HCl
Molecular FormulaC25H29Cl3N2
Molecular Weight463.87
Purity98
Density1.159g/cm3
Boiling Point495.3ºC at 760mmHg
Melting Point212 °C
Appearancesolid
Water SolubilityWater solubility: insoluble; easily soluble in: ch
Storage ConditionStore airtight at 2-8°C
ApplicationMeclizine is an H1 histamine receptor antagonist that can treat motion sickness.
HTC2933499090
MDL NumberMFCD00058199
SMILESCl.Cc1cccc(CN2CCN(CC2)C(c3ccccc3)c4ccc(Cl)cc4)c1
InChI1S/C25H27ClN2.ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;/h2-13,18,25H,14-17,19H2,1H3;1H
InChI KeyGJNMJOHYRWHJQB-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/11304_1_1104_22_9.pdf
BioactivityMeclizine is a histamine H1 receptor antagonist used to treat nausea and motion sicknessTarget: Histamine H1 ReceptorMeclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, possesses anticholinergic, central nervous system depressant, and local anesthetic effects [1]. Meclizine is an agonist ligand for mouse CAR (constitutive androstane receptor), and an inverse agonist for human CAR. Meclizine increases mCAR transactivation in a dose-dependent manner, stimulates binding of steroid receptor coactivator 1 to the murine receptor in vitro. In contrast, meclizine suppresses hCAR transactivation and inhibits the phenobarbital-induced expression of the CAR target genes, cytochrome p450 monooxygenase (CYP)2B10, CYP3A11, and CYP1A2, in primary hepatocytes derived from mice expressing hCAR, but not mCAR [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease References [1]. King, C.T., S.A. Weaver, and S.A. Narrod, Antihistamines and Teratogenicity in the Rat. J Pharmacol Exp Ther, 1965. 147: p. 391-8. [2]. Huang, W., et al., Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol Endocrinol, 2004. 18(10): p. 2402-8. Chemical & Physical Properties Density 1.159g/cm3 Boiling Point 495.3ºC at 760mmHg Melting Point 212 °C Molecular Formula C25H29Cl3N2 Molecular Weight 463.870 Flash Point 253.3ºC Exact Mass 462.139618 PSA 6.48000 LogP 7.03540 Vapour Pressure 6E-10mmHg at 25°C InChIKey GJNMJOHYRWHJQB-UHFFFAOYSA-N SMILES Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1.Cl Storage condition 2-8°C
Use ofProperties Name Meclizine dihydrochloride Synonym More Synonyms Meclizine dihydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease References [1]. King, C.T., S.A. Weaver, and S.A. Narrod, Antihistamines and Teratogenicity in the Rat. J Pharmacol Exp Ther, 1965. 147: p. 391-8. [2]. Huang, W., et al., Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol Endocrinol, 2004. 18(10): p. 2402-8. Chemical & Physical Properties Exact Mass 462.139618 PSA 6.48000 LogP 7.03540 InChIKey GJNMJOHYRWHJQB-UHFFFAOYSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is
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