CAS Number61-76-7
Synonymsconsdrin; (R)-3-Hydroxy-a-[(methylamino)methyl]benzenemethanol Hydrochloride; (R)-(-)-Phenylephrine (hydrochloride); almefrin; synasal; phenylephrine HCl; 3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride (1:1); 3-[(1R)-1-hydroxy-2-(méthylamino)éthyl]phénol chlorhydrate; l-1-(m-Hydroxyphenyl)-2-methylaminoethanol Hydrochloride; emagrin; fenilfar; AK-Dilate; Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, (αR)-, hydrochloride (1:1); benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, (αR)-, hydrochloride; rhinall; l-a-Hydroxy-b-methylamino-3-hydroxy-1-ethylbenzene Hydrochloride; AK-Nefrin; m-Sympatol; Metaoxedrin; Pyracort D; Phenylephrine hydrochloride; efricel; Mezaton; lexatol; uri; fenox; EINECS 200-517-3; MFCD00012605; 1-m-Hydroxy-a-[(methylamino)methyl]benzyl Alcohol H
Molecular FormulaC9H14ClNO2
Molecular Weight203.67
Purity98%
Boiling Point341.1ºC at 760 mmHg
Melting Point143-145 °C(lit.)
Appearanceliquid
EINECS200-659-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 61-76-7 |
| Catalog No. | 2A-9011249 |
| Chinese Name | 盐酸去氧肾上腺素 |
| Synonyms | consdrin; (R)-3-Hydroxy-a-[(methylamino)methyl]benzenemethanol Hydrochloride; (R)-(-)-Phenylephrine (hydrochloride); almefrin; synasal; phenylephrine HCl; 3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride (1:1); 3-[(1R)-1-hydroxy-2-(méthylamino)éthyl]phénol chlorhydrate; l-1-(m-Hydroxyphenyl)-2-methylaminoethanol Hydrochloride; emagrin; fenilfar; AK-Dilate; Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, (αR)-, hydrochloride (1:1); benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, (αR)-, hydrochloride; rhinall; l-a-Hydroxy-b-methylamino-3-hydroxy-1-ethylbenzene Hydrochloride; AK-Nefrin; m-Sympatol; Metaoxedrin; Pyracort D; Phenylephrine hydrochloride; efricel; Mezaton; lexatol; uri; fenox; EINECS 200-517-3; MFCD00012605; 1-m-Hydroxy-a-[(methylamino)methyl]benzyl Alcohol H |
| Molecular Formula | C9H14ClNO2 |
| Molecular Weight | 203.67 |
| Purity | 98 |
| Boiling Point | 341.1ºC at 760 mmHg |
| Melting Point | 143-145 °C(lit.) |
| Appearance | liquid |
| Water Solubility | ≥10 g/100 mL at 21 ºC |
| Storage Condition | This product should be sealed and stored in a dry |
| Packaging | III |
| Application | (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenergic receptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors. |
| EINECS | 200-659-6 |
| HTC | 2937229000 |
| SMILES | Cl.CNC[C@H](O)c1cccc(O)c1 |
| InChI | 1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1 |
| InChI Key | OCYSGIYOVXAGKQ-FVGYRXGTSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11249_1_61_76_7.pdf |
| Bioactivity | (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease Target pKi: 5.86 (α1D), 5.86 (α1B), 5.86 (α1A)[1] In Vitro (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist with pKi values of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively[1][2]. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis[3]. In Vivo Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes[4]. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema[5]. Animal Admin Rat: A total of 170 male Wistar rats are randomLy allocated into 17 groups (n=10) using random number tables. Short-term (40 minutes) mechanical ventilation with high tidal volume is performed to induce lung injury, impair active Na+ transport and lung liquid clearance in the rats. Unventilated rats serves as controls. To demonstrate the effect of phenylephrine on alveolar fluid clearance, phenylephrine at different concentrations (10, 1, 0.1, 0.01, and 0.001 μM) is injected into the alveolar space of the HVT ventilated rats[5]. References [1]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35. [2]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. [3]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13. [4]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65. [5]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6. Chemical & Physical Properties Boiling Point 341.1ºC at 760 mmHg Melting Point 143-145 °C(lit.) Molecular Formula C9H14ClNO2 Molecular Weight 203.666 Flash Point 163.4ºC Exact Mass 203.071304 PSA 52.49000 LogP 1.83790 Index of Refraction -45.5 ° (C=1, H2O) Water Solubility ≥10 g/100 mL at 21 ºC |
| Use of | (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively. Properties Articles160 Name phenylephrine hydrochloride Synonym More Synonyms Phenylephrine hydrochloride Biological Activity Description (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease pKi: 5.86 (α1D), 5.86 (α1B), 5.86 (α1A)[1] In Vitro (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist with pKi values of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively[1][2]. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis[3]. References [1]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35. [2]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. [3]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13. [4]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65. [5]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6. Chemical & Physical Properties Exact Mass 203.071304 PSA 52.49000 LogP 1.83790 |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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