| Chemical & Physical Properties | |
|---|---|
| CAS Number | 107097-80-3 |
| Catalog No. | 2A-9011246 |
| Chinese Name | 氯谷胺 |
| Synonyms | Loxiglumide; LOXIGLUMIDE; Loxizin; CR-1505 |
| Molecular Formula | C21H30Cl2N2O5 |
| Molecular Weight | 461.38 |
| Purity | ≥97 (HPLC) |
| Density | 1.233g/cm3 |
| Boiling Point | 632.2ºC at 760mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist. |
| HTC | 2924299090 |
| PubChem ID | 329825180 |
| MDL Number | MFCD00866772 |
| SMILES | CCCCCN(CCCOC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1 |
| InChI | 1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27) |
| InChI Key | QNQZBKQEIFTHFZ-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/11246_1_107097_80_3.pdf |
| Bioactivity | Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor Research Areas >> Metabolic Disease Target CCK-1 receptor[1] In Vivo The effects of pancreatic rest by oral administration of CCK-1 receptor antagonist Loxiglumide and pancreas stimulation are investigated via endogenous CCK release induced by po protease inhibitor camostat on the recovery of pancreatic secretory function, and biochemical and histological changes of the pancreas after acute hemorrhagic pancreatitis. Oral administration of CCK-1 receptor antagonist Loxiglumide with a dose of 50 mg/kg body weight inhibits pancreatic exocrine secretion for more than 12 h. Thus, every 12-h administration of Loxiglumide might have completely blocks the effect of endogenously released CCK on the pancreas (pancreatic rest)[1]. Animal Admin Rats[1] At 24 h after induction of acute hemorrhagic pancreatitis, rats are divided into four different treatment groups: standard rat chow (AP-C); standard rat chow with pancreatic rest (AP-R); standard rat chow with pancreatic stimulation (AP-S); and standard rat chow with pancreatic rest, followed by pancreatic stimulation (AP-R/S). Rats in the AP-C group receive 2 mL/kg body weight saline orally (po) via an orogastric tube twice daily (09:00 and 21:00 h) for 10 d; the AP-R group receive 50 mg/kg body weight of CCK-1 receptor antagonist Loxiglumide dissolved in 2 mL distilled water po twice daily for 10 d; the AP-S group receive 25 mg/kg body weight protease inhibitor Camostat, which is known to stimulate endogenous CCK release, dissolved in 2 mL distilled water po twice daily for 10 d; and the AP-R/S group receive 50 mg/kg body weight Loxiglumide twice daily for the first 5 d followed by 25 mg/kg body weight camostat twice daily for the next 5 d. Rats are fed ad libitum. On day 12 at 24 h after the last treatment and overnight fasting, pancreatic exocrine function and histological examination of the pancreas are performed. References [1]. Jia D, et al. Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats. World J Gastroenterol. 2015 Jul 7;21(25):7742-53. Chemical & Physical Properties Density 1.233g/cm3 Boiling Point 632.2ºC at 760mmHg Molecular Formula C21H30Cl2N2O5 Molecular Weight 461.37900 Flash Point 336.1ºC Exact Mass 460.15300 PSA 95.94000 LogP 4.40280 Appearance of Characters off white solid Vapour Pressure 7.51E-17mmHg at 25°C Index of Refraction 1.537 InChIKey QNQZBKQEIFTHFZ-UHFFFAOYSA-N SMILES CCCCCN(CCCOC)C(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 Storage condition -20℃ |
| Use of | Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist. Properties Articles25 Name 4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid Synonym More Synonyms Loxiglumide Biological Activity Description Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor Research Areas >> Metabolic Disease CCK-1 receptor[1] References [1]. Jia D, et al. Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats. World J Gastroenterol. 2015 Jul 7;21(25):7742-53. Chemical & Physical Properties Exact Mass 460.15300 PSA 95.94000 LogP 4.40280 Appearance of Characters off white solid Index of Refraction 1.537 InChIKey QNQZBKQEIFTHFZ-UHFFFAOYSA-N Storage condition -20℃ |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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