CAS Number82034-46-6
SynonymsChloromethyl 17a-ethoxycarbonyloxy-11b-hydroxyandrosta-1,4-diene-3-one-17b-carboxylate; Loteprednol (INN); Loteprednolum; Loteprednol Etabonate; 17a-Ethoxycarbonyloxy-D'-cortienic Acid Chloromethyl Ester; Loteprednol [INN:BAN]; Chloromethyl (11β,17α)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate; HGP 1; loteprednol
Molecular FormulaC24H31O7Cl1
Molecular Weight466.96
Purity98%
Density1.3±0.1 g/cm3
Boiling Point600.1±55.0 °C at 760 mmHg
Melting Point220.5-223.5ºC
Appearancewhite to beige
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 82034-46-6 |
| Catalog No. | 2A-9011242 |
| Chinese Name | 依碳氯替泼诺 |
| Synonyms | Chloromethyl 17a-ethoxycarbonyloxy-11b-hydroxyandrosta-1,4-diene-3-one-17b-carboxylate; Loteprednol (INN); Loteprednolum; Loteprednol Etabonate; 17a-Ethoxycarbonyloxy-D'-cortienic Acid Chloromethyl Ester; Loteprednol [INN:BAN]; Chloromethyl (11β,17α)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate; HGP 1; loteprednol |
| Molecular Formula | C24H31O7Cl1 |
| Molecular Weight | 466.96 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 600.1±55.0 °C at 760 mmHg |
| Melting Point | 220.5-223.5ºC |
| Appearance | white to beige |
| Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Storage Condition | -20°C Freezer |
| Application | Loteprednol Etabonate has anti-inflammatory activity and can be used in ophthalmology. |
| HTC | 2937229000 |
| MDL Number | MFCD00870765 |
| SMILES | CCOC(=O)OC1(C(=O)OCCl)CCC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC21C |
| InChI Key | DMKSVUSAATWOCU-HROMYWEYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/11242_1_82034_46_6.pdf |
| Bioactivity | Loteprednol Etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.IC50 Value:Target: Glucocorticoid Receptorin vitro:in vivo: Intravenous administration of loteprednol etabonate (5 mg/kg) to dogs revealed a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect. A pronounced binding of the drug to plasma protein (> 90%) and a high erythrocyte-buffer partition coefficient of 7.8 were determined in vitro. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology Natural Products >> Others References [1]. Noble S, Goa KL. Loteprednol etabonate: clinical potential in the management of ocular inflammation. BioDrugs. 1998 Oct;10(4):329-39. [2]. Szelenyi I, Hochhaus G, Heer S et al. Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways. Drugs Today (Barc). 2000 May;36(5):313-20. [3]. Howes JF. Loteprednol etabonate: a review of ophthalmic clinical studies. Pharmazie. 2000 Mar;55(3):178-83. [4]. Pavesio CE, Decory HH. Treatment of ocular inflammatory conditions with loteprednol etabonate. Br J Ophthalmol. 2008 Apr;92(4):455-9. [5]. Comstock TL, Decory HH. Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. Int J Inflam. 2012;2012:789623. [6]. Loteprednol Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 600.1±55.0 °C at 760 mmHg Melting Point 220.5-223.5ºC Molecular Formula C24H31ClO7 Molecular Weight 466.952 Flash Point 316.7±31.5 °C Exact Mass 466.175842 PSA 99.13000 LogP 3.17 Appearance of Characters white to beige Vapour Pressure 0.0±3.9 mmHg at 25°C Index of Refraction 1.571 InChIKey DMKSVUSAATWOCU-HROMYWEYSA-N SMILES CCOC(=O)OC1(C(=O)OCCl)CCC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC21C Storage condition -20°C Freezer Water Solubility DMSO: soluble5mg/mL, clear (warmed) |
| Use of | Properties Articles35 Name loteprednol etabonate Synonym More Synonyms Loteprednol etabonate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology Natural Products >> Others References [1]. Noble S, Goa KL. Loteprednol etabonate: clinical potential in the management of ocular inflammation. BioDrugs. 1998 Oct;10(4):329-39. [2]. Szelenyi I, Hochhaus G, Heer S et al. Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways. Drugs Today (Barc). 2000 May;36(5):313-20. [3]. Howes JF. Loteprednol etabonate: a review of ophthalmic clinical studies. Pharmazie. 2000 Mar;55(3):178-83. [4]. Pavesio CE, Decory HH. Treatment of ocular inflammatory conditions with loteprednol etabonate. Br J Ophthalmol. 2008 Apr;92(4):455-9. [5]. Comstock TL, Decory HH. Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. Int J Inflam. 2012;2012:789623. [6]. Loteprednol Chemical & Physical Properties Exact Mass 466.175842 PSA 99.13000 Appearance of Characters white to beige Index of Refraction 1.571 InChIKey DMKSVUSAATWOCU-HROMYWEYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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