CAS Number70374-39-9
SynonymsLorcam; CTX; 2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide; Lornoxicam; 6-Chlor-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazin-3-carboxamid-1,1-dioxid; Chlortenoxicam; Telos; 6-Chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide; MFCD00866163; 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide; Xefocam; Lornoxicamum; 6-Chloro-4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide; Ro 13-9297; Taigalor; Xefo; Safem
Molecular FormulaC13H10ClN3O4S2
Molecular Weight371.82
Purity≥98 (HPLC)%
Density1.7±0.1 g/cm3
Melting Point225-230°C (dec.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 70374-39-9 |
| Catalog No. | 2A-9011235 |
| Chinese Name | 氯诺昔康 |
| Synonyms | Lorcam; CTX; 2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide; Lornoxicam; 6-Chlor-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazin-3-carboxamid-1,1-dioxid; Chlortenoxicam; Telos; 6-Chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide; MFCD00866163; 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide; Xefocam; Lornoxicamum; 6-Chloro-4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide; Ro 13-9297; Taigalor; Xefo; Safem |
| Molecular Formula | C13H10ClN3O4S2 |
| Molecular Weight | 371.82 |
| Purity | ≥98 (HPLC) |
| Density | 1.7±0.1 g/cm3 |
| Melting Point | 225-230°C (dec.) |
| Appearance | powder |
| Water Solubility | Soluble in: dimethylformamide |
| Storage Condition | -20°C Freezer |
| Application | Lornoxicam is a highly active COX-1 and COX-2 inhibitor with IC50 of 5nM and 8nM respectively. It is a new non-steroidal anti-inflammatory compound. |
| HTC | 2934999090 |
| PubChem ID | 329825343 |
| MDL Number | MFCD00866163 |
| SMILES | CN1C(C(=O)Nc2ccccn2)=C(O)c3sc(Cl)cc3S1(=O)=O |
| InChI | 1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19) |
| InChI Key | WLHQHAUOOXYABV-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/11235_1_70374_39_9.pdf |
| Bioactivity | Lornoxicam, a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID).Target: COXLornoxicam showed a balanced inhibition of COX-1/-2 exhibiting the lowest IC50 (0.005 microM/0.008 microM) of the large panel of NSAIDs tested. lornoxicam showed a marked inhibition of IL-6 formation (IC50 54 microM) while the formation ofTNF-alpha, IL-1beta and IL-8 was only moderately affected [1]. Lornoxicam is effective in the treatment of patients with activated osteoarthritis; the analgesic and anti-inflammatory effects of lornoxicam are significantly superior to those of rofecoxib without inferiority in tolerability [2]. Lornoxicam was fully effective for prevention of hyperalgesia [3]. Related Catalog Research Areas >> Inflammation/Immunology Target COX-1:5 nM (IC50, in cells) COX-2:45 nM (IC50, in cells) References [1]. Spyra S, et al. COX-2-selective inhibitors celecoxib and deracoxib modulate transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2017 Aug;174(16):2696-2705. [2]. Rose, P. and C. Steinhauser, Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). Clin Drug Investig, 2004. 24(4): p. 227-36. [3]. Bianchi, M. and A.E. Panerai, Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. Pharmacol Res, 2002. 45(2): p. 101-5. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Melting Point 225-230°C (dec.) Molecular Formula C13H10ClN3O4S2 Molecular Weight 371.819 Exact Mass 370.980133 PSA 136.22000 LogP 2.18 Index of Refraction 1.741 InChIKey WLHQHAUOOXYABV-UHFFFAOYSA-N SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O Storage condition -20°C Freezer |
| Use of | Properties Articles33 Name lornoxicam Synonym More Synonyms Lornoxicam Biological Activity Related Catalog Research Areas >> Inflammation/Immunology COX-1:5 nM (IC50, in cells) COX-2:45 nM (IC50, in cells) References [2]. Rose, P. and C. Steinhauser, Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). Clin Drug Investig, 2004. 24(4): p. 227-36. [3]. Bianchi, M. and A.E. Panerai, Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. Pharmacol Res, 2002. 45(2): p. 101-5. Chemical & Physical Properties Exact Mass 370.980133 PSA 136.22000 Index of Refraction 1.741 InChIKey WLHQHAUOOXYABV-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H- thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H- thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide) International air transport hazard regulations: Toxic solid, organic, n.o.s. (6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2- thiazine-3-carboxamide 1,1-dioxide) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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